Relugolix Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 6, 2023.

Applies to relugolix: oral tablet.

Serious side effects of Relugolix

Along with its needed effects, relugolix may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking relugolix:

Less common

• Chest pain or discomfort
• confusion
• difficulty in speaking
• double vision
• headache
• inability to move the arms, legs, or facial muscles
• inability to speak
• nausea
• pain or discomfort in the arms, jaw, back, or neck
• slow speech
• sweating
• vomiting

Rare

• Bleeding gums
• cloudy urine
• coughing up blood
• decreased frequency or amount of urine
• difficult, burning, or painful urination
• difficulty in swallowing
• dizziness
• fainting
• frequent urge to urinate
• increased menstrual flow or vaginal bleeding
• increased thirst
• loss of appetite
• lower back or side pain
• nosebleeds
• paralysis
• prolonged bleeding from cuts
• red or black, tarry stools
• red or dark brown urine
• slow, fast, pounding, or irregular heartbeat
• swelling of the face, fingers, or lower legs
• trouble breathing
• unusual tiredness or weakness
• weight gain

Incidence not known

• Large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Other side effects of Relugolix

Some side effects of relugolix may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Bone pain
• constipation
• diarrhea
• difficulty in moving
• feeling of warmth
• fever
• lack or loss of strength
• muscle aches, cramps, pain, or stiffness
• neck pain
• pain in the joints
• redness of the face, neck, arms and occasionally, upper chest
• stomach cramps or tenderness
• swollen joints
• watery or bloody diarrhea

Less common

• Decreased interest in sexual intercourse
• discouragement
• feeling sad or empty
• inability to have or keep an erection
• irritability
• loss in sexual ability, desire, drive, or performance
• loss of interest or pleasure
• swelling of the breasts or breast soreness
• trouble concentrating
• trouble sleeping

For Healthcare Professionals

Applies to relugolix: oral tablet.

Hematologic

Very common (10% or more): Decreased hemoglobin (28%)

Uncommon (0.1% to 1%): hemorrhage (0.3%)^[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (30%)

Uncommon (0.1% to 1%): Fracture (0.3%)^[Ref]

Metabolic

Very common (10% or more): Increased glucose (44%), increased triglycerides (35%)

Common (1% to 10%): Increased weight^[Ref]

Psychiatric

Common (1% to 10%): Insomnia, depression, decreased libido^[Ref]

Genitourinary

Uncommon (0.1% to 1%): Urinary tract infection (0.5%)^[Ref]

Hepatic

Very common (10% or more): Increased alanine aminotransferase (27%), increased aspartate aminotransferase (18%)^[Ref]

Oncologic

Uncommon (0.1% to 1%): Metastatic lung cancer (0.3%)^[Ref]

Respiratory

Uncommon (0.1% to 1%): Pneumonia (0.3%)^[Ref]

General

Very common (10% or more): Fatigue (26%)^[Ref]

Renal

Uncommon (0.1% to 1%): Acute kidney injury up to 0.6%), urinary tract infection (0.5%)^[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Myocardial infarction (up to 0.8%), arrhythmia (0.6%), atrioventricular block (0.3%), cardiac failure (0.3%)

Frequency not reported: Fatal and non-fatal myocardial infarction, stroke^[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis^[Ref]

Endocrine

Very common (10% or more): Hot flash (54%)

Common (1% to 10%): Gynecomastia^[Ref]

Gastrointestinal

Very common (10% or more): Constipation (12%), diarrhea (12%)

Uncommon (0.1% to 1%): Abdominal pain (0.3%)^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer