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Relugolix Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 15, 2021.

Applies to relugolix: oral tablets.

Side effects include:

Adverse effects or laboratory abnormalities reported in ≥10 or ≥15%, respectively: Hot flush, musculoskeletal pain, fatigue, constipation, increased glucose concentrations, increased triglyceride concentrations, decreased hemoglobin, increased ALT and AST concentrations.

For Healthcare Professionals

Applies to relugolix: oral tablet.

Hematologic

Very common (10% or more): Decreased hemoglobin (28%)

Uncommon (0.1% to 1%): hemorrhage (0.3%)[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (30%)

Uncommon (0.1% to 1%): Fracture (0.3%)[Ref]

Metabolic

Very common (10% or more): Increased glucose (44%), increased triglycerides (35%)

Common (1% to 10%): Increased weight[Ref]

Psychiatric

Common (1% to 10%): Insomnia, depression, decreased libido[Ref]

Genitourinary

Uncommon (0.1% to 1%): Urinary tract infection (0.5%)[Ref]

Hepatic

Very common (10% or more): Increased alanine aminotransferase (27%), increased aspartate aminotransferase (18%)[Ref]

Oncologic

Uncommon (0.1% to 1%): Metastatic lung cancer (0.3%)[Ref]

Respiratory

Uncommon (0.1% to 1%): Pneumonia (0.3%)[Ref]

General

Very common (10% or more): Fatigue (26%)[Ref]

Renal

Uncommon (0.1% to 1%): Acute kidney injury up to 0.6%), urinary tract infection (0.5%)[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Myocardial infarction (up to 0.8%), arrhythmia (0.6%), atrioventricular block (0.3%), cardiac failure (0.3%)

Frequency not reported: Fatal and non-fatal myocardial infarction, stroke[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis[Ref]

Endocrine

Very common (10% or more): Hot flash (54%)

Common (1% to 10%): Gynecomastia[Ref]

Gastrointestinal

Very common (10% or more): Constipation (12%), diarrhea (12%)

Uncommon (0.1% to 1%): Abdominal pain (0.3%)[Ref]

References

1. "Product Information. Orgovyx (relugolix)." Myovant Sciences, Inc. (2021):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.