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Relugolix Dosage

Medically reviewed by Last updated on May 5, 2023.

Applies to the following strengths: 120 mg

Usual Adult Dose for Prostate Cancer

Loading Dose: 300 mg orally once on the first day
Maintenance Dose: 120 mg orally once a day


  • Treatment is usually continued upon development of nonmetastatic or metastatic castration-resistant prostate cancer in patients treated with GnRH receptor agonists and antagonists.

Use: For the treatment of adult patients with advanced prostate cancer

Renal Dose Adjustments

Data not available.

Liver Dose Adjustments

Data not available.

Dose Adjustments


  • Coadministration should be avoided.
  • If unavoidable, take this drug and separate dosing 6 hours apart.
  • If a short course with P-gp inhibitor is required, treatment with this drug may be interrupted for up to two weeks.
  • If treatment is interrupted for more than 7 days, resume with a 360 mg loading dose on the first day and continue with 120 mg once a day.

  • Coadministration Should be avoided.
  • If unavoidable, increase the dose of this drug to 240 mg once a day.
  • May resume at the recommended dose after discontinuation of the combined P-gp and strong CYP450 3A inducer.



  • None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available.

Other Comments

Administration advice:

  • The tablets should be swallowed whole.
  • Do not to crush or chew tablets.
  • This drug can be taken with or without food at approximately the same time each day.
  • Take a missed dose as soon as possible.
  • If a dose is missed and cannot be taken within 12 hours, skip that dose and take the next dose at the usual time.
  • If treatment is interrupted for greater than 7 days, restart with a loading dose of 360 mg on the first day and continue with a dose of 120 mg once a day.

Storage Requirements:
  • Store at room temperature.
  • Do not store above 30C (86F).

  • Cardiovascular: ECG
  • Endocrine: Prostate specific antigen levels
  • Metabolic: Serum electrolytes

Patient advice:
  • Advise the patient to read the FDA-approved patient labeling.
  • Inform patients that this drug can be harmful to a developing fetus and can cause loss of pregnancy.
  • Advise males with female partners of reproductive potential to use effective contraception during therapy and for at least 2 weeks after the last dose.
  • Advise patients that this drug may prolong the QT interval and to report any signs of symptoms of QT prolongation.
  • Inform patients that this drug may cause hot flashes, flushing of the skin, increased weight, decreased sex drive, and difficulties with erectile function.
  • Inform patients that this drug may cause infertility.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.