Skip to Content

RelCof PE Side Effects

Generic Name: chlorpheniramine / methscopolamine / phenylephrine

Note: This document contains side effect information about chlorpheniramine / methscopolamine / phenylephrine. Some of the dosage forms listed on this page may not apply to the brand name RelCof PE.

For the Consumer

Applies to chlorpheniramine / methscopolamine / phenylephrine: oral tablet chewable, oral tablet extended release

Get emergency medical help if you have any of these signs of an allergic reaction while taking chlorpheniramine/methscopolamine/phenylephrine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • little or no urinating;

  • fast, pounding, or irregular heartbeats;

  • pale skin, weakness, feeling short of breath; or

  • tremors, hallucinations, severe anxiety.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to chlorpheniramine/methscopolamine/phenylephrine: oral capsule extended release, oral liquid, oral suspension extended release, oral syrup, oral tablet, oral tablet chewable, oral tablet chewable extended release, oral tablet extended release

Nervous system

Nervous system side effects of phenylephrine have included headache, dizziness, nervousness, restlessness, tremor, insomnia, convulsions, and central nervous system depression. Antihistamines such as chlorpheniramine and anticholinergics such as methscopolamine may cause drowsiness and dizziness.[Ref]


Cardiovascular side effects of phenylephrine have included palpitations, arrhythmias, and cardiovascular collapse with hypotension.[Ref]


Psychiatric side effects of phenylephrine have included hallucinations, fear, and anxiety.[Ref]


Gastrointestinal side effects of phenylephrine have included nausea. Antihistamines such as chlorpheniramine and anticholinergics such as methscopolamine may cause excessive dryness of the nose, throat, and mouth.[Ref]


Respiratory side effects of phenylephrine have included respiratory difficulty.[Ref]


Genitourinary side effects of phenylephrine have included dysuria.[Ref]


General side effects of phenylephrine have included pallor and weakness.[Ref]


Ocular side effects including blurred vision may be caused by antihistamines such as chlorpheniramine and anticholinergics such as methscopolamine.[Ref]


1. "Product Information. Drize (chlorpheniramine/methscopolamine/PE)." King Pharmaceuticals Inc, Bristol, TN.

2. "Product Information. Ah-Chew D (phenylephrine)." WE Pharmaceuticals Inc, Ramona, CA.

3. "PDR Generics. 4th ed." Montvale, NJ: Medical Economics (1998):

Some side effects of RelCof PE may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

More about RelCof PE (chlorpheniramine / methscopolamine / phenylephrine)

Consumer resources

Other brands: AH-Chew II

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.