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Generic Name: methscopolamine (METH skoe POL a meen)
Brand Name: Pamine, Pamine Forte

Medically reviewed by on Jul 22, 2020 – Written by Cerner Multum

What is methscopolamine?

Methscopolamine reduces the secretions of certain organs in the body, such as the stomach.

Methscopolamine is used to reduce stomach acid secretion to help control peptic ulcers. methscopolamine does not help heal an ulcer.

Methscopolamine may also be used for purposes not listed in this medication guide.

Important Information

You should not take this medicine if you have glaucoma, a bladder obstruction or other urination problems, myasthenia gravis, severe constipation, or a stomach or bowel obstruction (including paralytic ileus or toxic megacolon).

Before taking this medicine

You should not use methscopolamine if you are allergic to it, or if you have:

  • glaucoma;

  • bladder obstruction or other urination problems;

  • a stomach or bowel obstruction (including paralytic ileus);

  • myasthenia gravis; or

  • severe constipation, or colitis or toxic megacolon.

Tell your doctor if you have ever had:

Older adults may be more sensitive to the effects of methscopolamine.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Methscopolamine can slow breast milk production. Tell your doctor if you are breast-feeding a baby.

Methscopolamine is not approved for use by anyone younger than 18 years old.

How should I take methscopolamine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Methscopolamine is usually taken 30 minutes before meals and at bedtime. Follow your doctor's dosing instructions.

Your doctor will need to check your progress on a regular basis.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include behavior changes, feeling restless, muscle weakness, loss of movement in any part of your body, fainting, or slowed breathing.

What should I avoid while taking methscopolamine?

Avoid becoming overheated or dehydrated during exercise and in hot weather. Methscopolamine can decrease sweating and you may be more prone to heat stroke.

methscopolamine may cause dizziness or blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Drinking alcohol with this medicine can cause side effects.

Methscopolamine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using methscopolamine and call your doctor at once if you have:

  • painful or difficult urination;

  • little or no urination;

  • pounding heartbeats or fluttering in your chest;

  • severe diarrhea; or

  • confusion, nervousness.

Common side effects may include:

  • headache;

  • drowsiness, dizziness;

  • blurred vision;

  • nausea, vomiting, constipation, bloating;

  • dry mouth, decreased sense of taste;

  • decreased sweating; or

  • trouble sleeping.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Methscopolamine dosing information

Usual Adult Dose for Peptic Ulcer:

Average dose: 2.5 mg orally one half hour before meals, and 2.5 to 5 mg at bedtime
-A starting dose of 12.5 mg daily (total dose) is clinically effective in most patients without appreciable side effects.
-Patients with severe symptoms needing prompt relief: Start with 5 mg orally one half hour before meals and at bedtime (total daily dose: 20 mg)

-This drug has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
-Patients on reduced doses due to side effects often show adequate symptomatic relief and effective antisecretory effects.
-Patients with severe side effects without appreciable symptomatic relief may be unsuited for this therapy.
-Patients with an intolerance to other anticholinergic drugs may be intolerant of this medication; start these patients at a lower dosage.

Use(s): Adjunctive therapy for peptic ulcer

What other drugs will affect methscopolamine?

Methscopolamine slows the digestive tract, which can make it harder for your body to absorb other medicines you take by mouth. Tell your doctor if any of your oral medications do not seem to work as well while you are taking methscopolamine.

Using methscopolamine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect methscopolamine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.