Skip to Content

methscopolamine

Generic Name: methscopolamine (METH skoe POL a meen)
Brand Name: Pamine, Pamine Forte

What is methscopolamine?

Methscopolamine reduces the secretions of certain organs in the body, such as the stomach.

Methscopolamine is used to reduce stomach acid secretion to help control peptic ulcers.

This medication does not help heal a stomach ulcer.

Methscopolamine may also be used for other purposes not listed in this medication guide.

Important Information

You should not take this medication if you have glaucoma, urination problems due to a bladder obstruction, myasthenia gravis, a stomach disorder called paralytic ileus, or a blockage in your intestines, or severe ulcerative colitis with toxic megacolon.

Before taking methscopolamine, tell your doctor if you are allergic to any drugs, or if you have ulcerative colitis, kidney or liver disease, a thyroid disorder, high blood pressure or heart disease, a heart rhythm disorder, an enlarged prostate, or if you have had an ileostomy or colostomy.

To be sure this medication is helping your condition, you may need blood tests and x-rays or other scans of your stomach or intestines on a regular basis. Your stools may also need to be tested for the presence of blood. Do not miss any scheduled appointments.

Methscopolamine can cause side effects that may impair your vision, thinking, or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by methscopolamine. Tell your doctor if you regularly use any of these medicines.

Avoid drinking alcohol. It can increase some of the side effects of methscopolamine.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Methscopolamine can decrease perspiration and you may be more prone to heat stroke.

Stop using this medication and call your doctor at once if you diarrhea, fast or pounding heartbeats, or if you are urinating less than usual or not at all.

Older adults may be more sensitive to the side effects of methscopolamine.

Before taking this medicine

You should not take this medication if you are allergic to methscopolamine, or if you have:

  • glaucoma;

  • if you are unable to urinate due to a bladder obstruction;

  • myasthenia gravis;

  • a stomach disorder called paralytic ileus; or

  • a blockage in your intestines, or severe ulcerative colitis with toxic megacolon.

Before taking methscopolamine, tell your doctor if you are allergic to any drugs, or if you have:

  • ulcerative colitis;

  • kidney disease;

  • liver disease;

  • a thyroid disorder;

  • high blood pressure (hypertension);

  • heart disease, congestive heart failure;

  • a heart rhythm disorder;

  • an enlarged prostate and problems with urination; or

  • if you have had an ileostomy or colostomy.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use methscopolamine.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether methscopolamine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the side effects of methscopolamine.

How should I take methscopolamine?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Methscopolamine is usually taken 30 minutes before meals and at bedtime.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

To be sure this medication is helping your condition, you may need blood tests and x-rays or other scans of your stomach or intestines on a regular basis. Your stools may also need to be tested for the presence of blood. Do not miss any scheduled appointments.

Store methscopolamine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include muscle weakness or limpness, feeling restless or excited, unusual thoughts or behavior, numbness, warmth or tingling under your skin, or feeling like you might pass out.

What should I avoid while taking methscopolamine?

Methscopolamine can cause side effects that may impair your vision, thinking, or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by methscopolamine. Tell your doctor if you regularly use any of these medicines.

Avoid drinking alcohol. It can increase some of the side effects of methscopolamine.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Methscopolamine can decrease perspiration and you may be more prone to heat stroke.

Methscopolamine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using methscopolamine and call your doctor at once if you have any of these serious side effects:

  • diarrhea;

  • fast or pounding heartbeats;

  • urinating less than usual or not at all.

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Methscopolamine dosing information

Usual Adult Dose for Peptic Ulcer:

Average dose: 2.5 mg orally one half hour before meals, and 2.5 to 5 mg at bedtime
-A starting dose of 12.5 mg daily (total dose) is clinically effective in most patients without appreciable side effects.
-Patients with severe symptoms needing prompt relief: Start with 5 mg orally one half hour before meals and at bedtime (total daily dose: 20 mg)

Comments:
-This drug has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
-Patients on reduced doses due to side effects often show adequate symptomatic relief and effective antisecretory effects.
-Patients with severe side effects without appreciable symptomatic relief may be unsuited for this therapy.
-Patients with an intolerance to other anticholinergic drugs may be intolerant of this medication; start these patients at a lower dosage.

Use(s): Adjunctive therapy for peptic ulcer

What other drugs will affect methscopolamine?

Many drugs can interact with methscopolamine. Below is just a partial list. Tell your doctor if you are using:

This list is not complete and there may be other drugs that can interact with methscopolamine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about methscopolamine.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.07.

Last reviewed: December 15, 2010
Date modified: January 03, 2018

Hide