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Methscopolamine Bromide use while Breastfeeding

Drugs containing Methscopolamine Bromide: Dexodryl Suspension, Dexodryl, Extendryl, AlleRx Dose Pack, Rescon Extended Release, SymPak II, Extendryl JR, Mescolor, Relcof PSE, Dallergy PSE, Show all 119 »RelCof DN PSE, Xiral SR, DuraHist, DryMax, Rhinolar, DriHist, PCM Allergy, Re-Drylex Jr, PCM-LA, Chlor-Mes, Histatab PH, Ah-chew Ultra, Redur-PCM, AlleRx Dose Pack PE (PM Dose), QV-Allergy, Extendryl Seniors, Dallergy ER, Aerokid, Denaze, Ralix, Hista-Vent PSE, AllePak, Amdry-C, DuraHist D, Respivent-D, Extendryl PSE, Amdry-D, AlleRx Dose Pack (AM Dose), Sudatrate, Extendryl PEM, AlleRx Dose Pack PE (AM Dose), Pamine Forte, Pamine, Pamine FQ, Histatab D, D-Hist D, Time-Hist QD, DexPhen M, Re-Drylex, CoryZa-D, Histatab, VisRx Dose Pack, Allergy AM-PM Dose Pack, ScopoHist, Coldamine, Pseudo CM TR, Allergy DN, Rhinaclear, Omnihist II LA, AH-Chew II, Norel SD, PCM, Ryneze, Nohist Plus, DuraTan PE, Allergy DN PE, AlleRx Dose Pack (PM Dose), ScopoHist Syrup, RelCof PE, RelCof DN PE, Nohist PE, DriHist SR, Dehistine, Duravent, Allerx Dose Pack DF, Dallergy SR, aeroHist, RespiVent DF, NoHist EXT, Allergy DN II, AlleRx DF, RelCof CPM, SymPak, Extendryl DM, SymPak DM, Pannaz, Nacon, Pseudox M, Nohist Plus Jr, Duradryl Chewable, Durahist PE, Duravent DA, Pannaz S, Chlor-Mes D, WE Allergy, Ex-Histine, Drysec, Drize, Duradryl JR, Duradryl, AH-Chew, Liqui-Allergy, DA II, Hista-Vent DA, Omnihist L.A., Aerohist Plus, DA Chewable, Extendryl Chews, Prehist D, Extendryl SR, Sinodec, ScopoHist-PE, SymPak PDX, Triall, Ah-Chew Ultra Tannate, CPM-PE-MSC, Dallergy PE, Duradryl SR, Allerx-D

Medically reviewed by Last updated on Mar 11, 2020.

Methscopolamine Bromide Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of methscopolamine bromide during breastfeeding. Because methscopolamine bromide is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant. Long-term use of methscopolamine bromide might reduce milk production or milk letdown, but a single dose is unlikely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).

To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date. br>

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[1][2][3][4][5] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[6] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


Aaron DK, Ely DG, Deweese WP et al. Reducing milk production in ewes at weaning using restricted feeding and methscopolamine bromide. J Anim Sci. 1997;75:1434-42. [PubMed: 9250502]
Powell MR, Keisler DH. A potential strategy for decreasing milk production in the ewe at weaning using a growth hormone release blocker. J Anim Sci. 1995;73:1901-5. [PubMed: 7592071]
Daniel JA, Thomas MG, Powell MR, Keisler DH. Methscopolamine bromide blocks hypothalmic-stimulated release of growth hormone in ewes. J Anim Sci. 1997;75:1359-62. [PubMed: 9159285]
Bizzarro A, Iannucci F, Tolino A et al. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980;7:108-11. [PubMed: 6788407]
Svennersten K, Nelson L, Juvnas-Moberg K. Atropinization decreases oxytocin secretion in dairy cows. Acta Physiol Scand. 1992;145:193-4. [PubMed: 1636447]
Masala A, Alagna S, Devilla L et al. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982;5:53-5. [PubMed: 6808052]

Substance Identification

Substance Name

Methscopolamine Bromide

CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Muscarinic Antagonists
  • Parasympatholytics

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Further information

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