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Methscopolamine Bromide use while Breastfeeding

Medically reviewed by Last updated on Oct 27, 2022.

Drugs containing Methscopolamine Bromide: PCM, Duradryl, Nacon, Pannaz, Pamine Forte, Extendryl, D-Hist D, Pamine, SymPak II, Pannaz S, Show all 119 »Pseudox M, SymPak DM, Extendryl DM, SymPak, RelCof CPM, AlleRx DF, Allergy DN II, NoHist EXT, RespiVent DF, aeroHist, Allerx Dose Pack DF, Dexodryl Suspension, Dexodryl, Ryneze, Duravent, Dehistine, DriHist SR, Nohist PE, RelCof DN PE, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Allergy DN PE, DuraTan PE, Nohist Plus, Nohist Plus Jr, Dallergy SR, Duradryl Chewable, Aerohist Plus, Duradryl SR, Dallergy PE, CPM-PE-MSC, Ah-Chew Ultra Tannate, Triall, SymPak PDX, ScopoHist-PE, Sinodec, Extendryl SR, Prehist D, Extendryl Chews, DA Chewable, Omnihist L.A., Duravent DA, Hista-Vent DA, DA II, Liqui-Allergy, AH-Chew, Duradryl JR, Drize, Drysec, Ex-Histine, WE Allergy, Chlor-Mes D, Norel SD, Durahist PE, Omnihist II LA, AH-Chew II, Ralix, Denaze, Aerokid, Dallergy ER, Extendryl Seniors, QV-Allergy, Rescon Extended Release, AlleRx Dose Pack PE (PM Dose), Redur-PCM, Ah-chew Ultra, Histatab PH, Chlor-Mes, PCM Allergy, Re-Drylex Jr, Extendryl JR, DriHist, AlleRx Dose Pack, Rhinolar, DryMax, DuraHist, Xiral SR, RelCof DN PSE, Dallergy PSE, Relcof PSE, Mescolor, Hista-Vent PSE, PCM-LA, Amdry-C, Time-Hist QD, AllePak, Rhinaclear, Allergy DN, Pseudo CM TR, Coldamine, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, CoryZa-D, Re-Drylex, DexPhen M, DuraHist D, Histatab D, Pamine FQ, AlleRx Dose Pack PE (AM Dose), Extendryl PEM, Sudatrate, AlleRx Dose Pack (AM Dose), Amdry-D, Extendryl PSE, Respivent-D, Allerx-D

Methscopolamine Bromide Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of methscopolamine bromide during breastfeeding. Because methscopolamine bromide is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant. Long-term use of methscopolamine bromide might reduce milk production or milk letdown, but a single dose is unlikely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).

To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[1-5] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[6] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


Aaron DK, Ely DG, Deweese WP, et al. Reducing milk production in ewes at weaning using restricted feeding and methscopolamine bromide. J Anim Sci. 1997;75:1434–42. [PubMed: 9250502]
Powell MR, Keisler DH. A potential strategy for decreasing milk production in the ewe at weaning using a growth hormone release blocker. J Anim Sci. 1995;73:1901–5. [PubMed: 7592071]
Daniel JA, Thomas MG, Powell MR, et al. Methscopolamine bromide blocks hypothalmic-stimulated release of growth hormone in ewes. J Anim Sci. 1997;75:1359–62. [PubMed: 9159285]
Bizzarro A, Iannucci F, Tolino A, et al. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980;7:108–11. [PubMed: 6788407]
Svennersten K, Nelson L, Juvnäs-Moberg K. Atropinization decreases oxytocin secretion in dairy cows. Acta Physiol Scand. 1992;145:193–4. [PubMed: 1636447]
Masala A, Alagna S, Devilla L, et al. Muscarinic receptor blockade by pirenzepine: Effect on prolactin secretion in man. J Endocrinol Invest. 1982;5:53–5. [PubMed: 6808052]

Substance Identification

Substance Name

Methscopolamine Bromide

CAS Registry Number


Drug Class

Breast Feeding


Muscarinic Antagonists


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Further information

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