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Chlorpheniramine / methscopolamine / phenylephrine Pregnancy and Breastfeeding Warnings

Chlorpheniramine / methscopolamine / phenylephrine is also known as: Aerohist Plus, AlleRx Dose Pack (PM Dose), Allergy DN PE, CPM-PE-MSC, Dallergy PE, Dallergy SR, Dehistine, Denaze, DriHist SR, DuraTan PE, Duradryl Chewable, Duradryl SR, Durahist PE, Duravent, Nohist PE, Nohist Plus, Nohist Plus Jr, Omnihist II LA, PCM, RelCof DN PE, RelCof PE, Rescon Extended Release, ScopoHist Syrup, ScopoHist-PE, Triall

Chlorpheniramine / methscopolamine / phenylephrine Pregnancy Warnings

Reproductive animal studies with chlorpheniramine demonstrated no harm to the fetus. Reproductive animal studies have not been reported with methscopolamine and phenylephrine. There are no controlled data in human pregnancy. The Collaborative Perinatal Project monitored 1,070 first trimester exposures and 3,931 exposures which occurred anytime during pregnancy. No evidence was found to suggest a relationship to large categories of malformations. Antihistamine exposure in the first trimester in general was not associated with an increased risk of malformations.

Chlorpheniramine/methscopolamine/phenylephrine has been assigned to pregnancy category C by the FDA. Chlorpheniramine/methscopolamine/phenylephrine is only recommended for use during pregnancy when benefit outweighs risk.

See references

Chlorpheniramine / methscopolamine / phenylephrine Breastfeeding Warnings

Small amounts of sympathomimetic amines and antihistamines are excreted in breast milk and because of the risk of adverse reactions in nursing infants (excitement or irritability), use is not recommended. Anticholinergics and antihistamines may inhibit lactation.

See references

References for pregnancy information

  1. "Product Information. Chlortrimeton (chlorpheniramine)." Schering-Plough, Liberty Corner, NJ.
  2. "Product Information. Rescon MX (chlorpheniramine/methscopolamine/PE)." Capellon Pharmaceuticals, Fort Worth, TX.
  3. Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
  4. Nelson MA, Forfar JO "Associations between drugs administered during pregnancy and congenital abnormalities of the fetus." Br Med J 1 (1971): 523-7
  5. "Product Information. Drize (chlorpheniramine/methscopolamine/PE)." King Pharmaceuticals Inc, Bristol, TN.

References for breastfeeding information

  1. "Product Information. Drize (chlorpheniramine/methscopolamine/PE)." King Pharmaceuticals Inc, Bristol, TN.
  2. "Product Information. Chlortrimeton (chlorpheniramine)." Schering-Plough, Liberty Corner, NJ.
  3. "Product Information. Rescon MX (chlorpheniramine/methscopolamine/PE)." Capellon Pharmaceuticals, Fort Worth, TX.

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