Prevacid 24HR Side Effects
Generic name: lansoprazole
Medically reviewed by Drugs.com. Last updated on Jan 4, 2023.
Note: This document contains side effect information about lansoprazole. Some dosage forms listed on this page may not apply to the brand name Prevacid 24HR.
Applies to lansoprazole: oral capsule delayed release, oral powder for suspension, oral tablet disintegrating delayed release.
Serious side effects of Prevacid 24HR
Along with its needed effects, lansoprazole (the active ingredient contained in Prevacid 24HR) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lansoprazole:
More common
Less common
Rare
- Anxiety
- blurred vision
- chest pain or discomfort
- colds
- constipation
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, pounding, or irregular heartbeat or pulse
- increased cough
- lightheadedness, dizziness or fainting
- mental depression
- muscle pain
- nervousness
- pain or discomfort in the arms, jaw, back, or neck
- pounding in the ears
- rectal bleeding
- slow or irregular heartbeat
- sweating
- unusual bleeding or bruising
Incidence not known
- Back or leg pains
- bleeding gums
- blistering, peeling, or loosening of the skin
- bloating
- bloody, black, or tarry stools
- change in mental status
- chest tightness
- chills
- clay colored stools
- confusion
- cough
- dark or bloody urine
- difficulty with swallowing
- drowsiness
- fast heartbeat
- fever
- general body swelling
- hives
- hoarseness
- indigestion
- loss of appetite
- lower back or side pain
- mood or mental changes
- muscle cramps in the hands, arms, feet, legs, or face
- muscle spasms (tetany) or twitching seizures
- nosebleeds
- numbness and tingling around the mouth, fingertips, or feet
- painful or difficult urination
- pains in the stomach, side, or abdomen, possibly radiating to the back
- pale skin
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- seizures
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stomach tenderness
- swelling of the feet or lower legs
- swollen or painful glands
- trembling
- trouble breathing
- unusual tiredness or weakness
- yellow eyes or skin
Other side effects of Prevacid 24HR
Some side effects of lansoprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Dizziness
- headache
Less common
- Bleeding, blistering, burning, coldness, or discoloration of the skin
- mild nausea
Rare
- Bad, unusual, or unpleasant (after) taste
- bad breath
- belching
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- change in taste
- difficulty in moving
- double vision
- feeling of heat or warmth
- flushing or redness of the skin, especially on the face and neck
- lack or loss of strength
- loss or thinning of the hair
- mild diarrhea
- mild headache
- mild vomiting
- persistent non-healing sore
- reddish patch or irritated area
- shiny bump
- stomach discomfort or upset
- swollen joints
- white, yellow or waxy scar-like area
Incidence not known
- Decrease in passing urine (dribbling)
- decrease in the frequency of urination
- decrease in urine volume
- difficulty with speaking
For Healthcare Professionals
Applies to lansoprazole: compounding powder, intravenous powder for injection, oral delayed release capsule, oral granule for reconstitution, oral suspension, oral tablet disintegrating.
General
The most commonly reported side effects include headache, dizziness, fatigue, and malaise.[Ref]
Gastrointestinal
Pseudomembranous colitis may occur with triple therapy for the eradication of H. pylori.
The majority of patients with severe/protracted cases of diarrhea who discontinued treatment had symptom resolution.[Ref]
Common (1% to 10%): Abdominal pain, benign fundic gland polyps, constipation, diarrhea, dry mouth, flatulence, nausea, stomachache, vomiting
Rare (0.01% to 0.1%): Candidiasis of the esophagus, glossitis, macroscopic/microscopic colitis, pancreatitis
Very rare (less than 0.01%): Colitis, stomatitis
Frequency not reported: Abdomen enlarged, abnormal stools, bezoar, cardiospasm, collagenous colitis, duodenitis, dyspepsia, dysphagia, enteritis, epigastric discomfort, eructation, esophageal disorder, esophageal stenosis, esophageal ulcer, esophagitis, fecal discoloration, gastric nodules/fundic gland polyps, gastritis, gastroenteritis, gastrointestinal anomaly/disorder/hemorrhage, gastrointestinal moniliasis, gum hemorrhage, halitosis, hematemesis, hiatal hernia, impaired gastric emptying, increased salivation, melena, mouth ulceration, positive fecal occult blood, protracted diarrhea, pseudomembranous colitis/Clostridium difficile-associated diarrhea, rectal disorder, rectal hemorrhage, sore mouth, tenesmus, tongue disorder, ulcerative colitis, ulcerative stomatitis[Ref]
Dermatologic
Skin rashes, urticaria, and pruritus generally resolved upon discontinuation of therapy.[Ref]
Common (1% to 10%): Itching, pruritus, rash, urticaria
Rare (0.01% to 0.1%): Bullous rashes, cutaneous lupus erythematosus, erythema multiforme, erythematous rashes, hair loss, hair thinning, hyperhidrosis, petechia, photosensitivity, purpura, serious dermatological reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis
Frequency not reported: Acne, alopecia, contact dermatitis, dry skin, fixed eruption, hair disorder, maculopapular rash, nail disorder, subacute cutaneous lupus erythematosus, skin disorder, sweating
Postmarketing reports: Fatal toxic epidermal necrolysis[Ref]
Nervous system
Common (1% to 10%): Dizziness, headache, taste perversion
Rare (0.01% to 0.1%): Paresthesia, somnolence, taste disturbance, tremor, vertigo
Frequency not reported: Amnesia, cerebrovascular accident/cerebral infarction, convulsion, dementia, hemiplegia, hyperkinesia, hypertonia, hypesthesia, migraine, parosmia, syncope, taste loss
Postmarketing reports: Speech disorder[Ref]
Hepatic
Common (1% to 10%): Increased liver enzyme levels (alkaline phosphatase, ALT, AST, GGT)
Rare (0.01% to 0.1%): Hepatitis, jaundice
Frequency not reported: Bilirubinemia, cholelithiasis, increased alkaline phosphatase, increased ALT, increased AST, increased GGT
Postmarketing reports: Hepatotoxicity[Ref]
Other
Common (1% to 10%): Fatigue
Rare (0.01% to 0.1%): Fever
Frequency not reported: Additional isolated laboratory abnormalities, asthenia, chills, deafness, ear disorder, malaise, otitis media, pain, tinnitus[Ref]
Respiratory
Common (1% to 10%): Dry throat
Frequency not reported: Asthma, bronchitis, cough increased, dyspnea, epistaxis, hemoptysis, hiccup, hoarseness, interstitial pneumonia, lung fibrosis, pharyngitis, pleural disorder, pneumonia, respiratory disorder, rhinitis, sinusitis, sore throat, stridor, upper respiratory tract infection, upper respiratory tract inflammation, wheezing[Ref]
A definitive relationship between use of this drug and interstitial pneumonia has not been established.[Ref]
Musculoskeletal
Uncommon (0.1% to 1%): Arthralgia, fracture of the hip/wrist/spine, myalgia
Frequency not reported: Arthritis, back pain, bone disorder, bone fracture, joint disorder, leg cramps, myasthenia, musculoskeletal pain, neck pain, neck rigidity, synovitis, systemic lupus erythematosus
Postmarketing reports: Myositis[Ref]
Hematologic
Uncommon (0.1% to 1%): Eosinophilia, leukopenia, thrombocytopenia
Rare (0.01% to 0.1%): Agranulocytosis, anemia, hematological effects, neutropenia, pancytopenia
Frequency not reported: Abnormal albumin globulin (AG) ratio, abnormal platelets, abnormal RBC, abnormal WBC, bruising, contusion, decreased platelets, decreased WBC, hemoglobin decreased, hemolysis, increased globulins, increased platelets, increased WBC, lymphadenopathy
Postmarketing reports: Aplastic anemia, hemolytic anemia, thrombotic thrombocytopenic purpura[Ref]
Psychiatric
Rare (0.01% to 0.1%): Confusion, hallucination, insomnia, restlessness
Frequency not reported: Abnormal dreams, abnormal thinking, agitation, anxiety, apathy, depersonalization, emotional lability, hostility aggravated, libido increased/decreased, nervousness, neurosis, sleep disorder, visual hallucinations[Ref]
Cardiovascular
Uncommon (0.1% to 1%): Edema
Frequency not reported: Angina, arrhythmia, bradycardia, chest pain (not otherwise specified [NOS]), hypertension, hypotension, myocardial infarction, palpitations, peripheral edema, shock/circulatory failure, tachycardia, vasodilation[Ref]
Metabolic
Rare (0.01% to 0.1%): Anorexia, hypomagnesemia
Very rare (less than 0.01%): Hyponatremia, increased cholesterol/triglyceride levels
Frequency not reported: Avitaminosis, blood potassium increased, cyanocobalamin (vitamin B12) deficiency), decreased cholesterol, dehydration, diabetes mellitus, gout, hunger, hyperglycemia, hyperlipemia, hypoglycemia, increased appetite, increased lactate dehydrogenase (LDH), increased/decreased electrolytes, thirst, weight gain/loss[Ref]
A definitive relationship between use of this drug and hyponatremia has not been established.[Ref]
Genitourinary
Rare (0.01% to 0.1%): Erectile dysfunction, impotence
Frequency not reported: Abnormal menses, albuminuria, breast enlargement, breast pain, breast tenderness, crystal urine present, dysmenorrhea, dysuria, hematuria, leukorrhea, menorrhagia, menstrual disorder, pelvic pain, penis disorder, polyuria, testis disorder, urethral pain, urinary frequency, urinary retention, urinary tract infection, urinary urgency, urination impaired, vaginitis[Ref]
Hypersensitivity
Rare (0.01% to 0.1%): Angioedema
Very rare (less than 0.01%): Anaphylactic reaction, anaphylactic shock
Frequency not reported: Allergic reaction
Postmarketing reports: Anaphylactoid reactions[Ref]
Ocular
Rare (0.01% to 0.1%): Visual disturbances
Frequency not reported: Abnormal vision, amblyopia, blepharitis, blurred vision, cataract, conjunctivitis, diplopia, dry eyes, eye disorder, eye pain, glaucoma, photophobia, ptosis, retinal degeneration/disorder, visual field defect[Ref]
Renal
Rare (0.01% to 0.1%): Interstitial nephritis
Frequency not reported: Acute interstitial nephritis, blood urea increased, kidney calculus, kidney pain, glycosuria, increased creatinine, renal dysfunction, renal failure[Ref]
Some cases of interstitial nephritis resulted in renal failure.[Ref]
Endocrine
Rare (0.01% to 0.1%): Gynecomastia
Frequency not reported: Goiter, hypothyroidism, increased gastrin levels, increased glucocorticoids[Ref]
Oncologic
Frequency not reported: Carcinoma, laryngeal neoplasia, metaplasia, skin carcinoma[Ref]
Immunologic
Frequency not reported: Candidiasis, flu syndrome, infection NOS[Ref]
More about Prevacid 24HR (lansoprazole)
- Check interactions
- Compare alternatives
- Reviews (2)
- Drug images
- Dosage information
- During pregnancy
- Drug class: proton pump inhibitors
- Breastfeeding
Professional resources
Other formulations
Related treatment guides
References
1. "Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc (2001):
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html" (2008):
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.