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Prandin Side Effects

Generic Name: repaglinide

Note: This page contains side effects data for the generic drug repaglinide. It is possible that some of the dosage forms included below may not apply to the brand name Prandin.

In Summary

Common side effects of Prandin include: hypoglycemia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to repaglinide: oral tablet

As well as its needed effects, repaglinide (the active ingredient contained in Prandin) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking repaglinide, check with your doctor immediately:

More common:
  • Convulsions (seizures)
  • unconsciousness

Severity: Moderate

If any of the following side effects occur while taking repaglinide, check with your doctor or nurse as soon as possible:

More common:
  • Cough
  • fever
  • low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness
  • pain in the chest
  • runny or stuffy nose
  • shortness of breath
  • sinus congestion with pain
  • sneezing
  • sore throat
Less common:
  • Bloody or cloudy urine
  • burning, painful, or difficult urination
  • chest pain
  • chills
  • frequent urge to urinate
  • problems with teeth
  • skin rash, itching, or hives
  • tearing of eyes
  • tightness in chest
  • trouble in breathing
  • vomiting
  • wheezing
  • Black, tarry stools
  • blood in stools
  • fast or irregular heartbeat
  • hoarseness
  • lower back or side pain
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Minor Side Effects

Some repaglinide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Back pain
  • diarrhea
  • joint pain
Less common:
  • Constipation
  • feeling of burning, numbness, tightness, tingling, warmth, or heat
  • indigestion

For Healthcare Professionals

Applies to repaglinide: oral tablet


The most frequently reported adverse reactions were changes in blood glucose levels; the occurrence of these reactions was dependent on individual factors such as dietary habits, dose, exercise, and stress.[Ref]


Very common (10% or more): Hypoglycemia (up to 31%)[Ref]

In 12 to 24 week clinical trials, hypoglycemia occurred in 31% of patients receiving this drug compared to 7% of placebo-treated patients. In 1 year trials, hypoglycemia occurred in 16% of patients receiving this drug compared to 19% and 20% of glipizide and glyburide patients, respectively.[Ref]


Cardiovascular events were evaluated in trials comparing this drug to sulfonylureas. Serious cardiovascular events including ischemia with this drug were higher at 4% than for sulfonylurea drugs (3%). No excess mortality was associated with this increase. Selected cardiovascular events including hypertension, abnormal EKG, MI, arrhythmias, and palpitations were observed at 1% or less and no more frequently with this drug than with comparator drugs.

Trials of this drug in combination with NPH insulin found 6 serious events of myocardial ischemia.[Ref]

Common (1% to 10%): Chest pain, angina, serious cardiovascular events including ischemia
Frequency not reported: Hypertension, abnormal EKG, MI, arrhythmias, palpitations[Ref]


Common (1% to 10%): Allergy
Uncommon (0.1% to 1%): Allergic skin reactions such as rash, urticaria, and pruritus
Frequency not reported: Anaphylactoid reactions[Ref]

Anaphylactoid reactions were reported in less than 1% of patients. Allergic skin reactions such as rash, urticaria, and pruritus have been observed. There is no reason to suspect cross-allergenicity with sulfonylurea drugs due to the difference in chemical structure.[Ref]


Common (1% to 10%): Nausea, diarrhea, constipation, vomiting, dyspepsia, tooth disorder
Postmarketing reports: Pancreatitis[Ref]

Nervous system

Very common (10% or more): Headache (up to 11%)
Common (1% to 10%): Paresthesia[Ref]


Common (1% to 10%): Arthralgia, back pain[Ref]


Very common (10% or more): Upper respiratory infection (up to 16%)
Common (1% to 10%): Sinusitis, rhinitis, bronchitis[Ref]


Postmarketing experience has included reports of severe hepatic dysfunction including jaundice and hepatitis.[Ref]

Frequency not reported: Elevated liver enzymes
Postmarketing reports: Severe hepatic dysfunction including jaundice and hepatitis[Ref]


Thrombocytopenia or leukopenia have been reported in less than 1% of patients.[Ref]

Frequency not reported: Thrombocytopenia, leukopenia
Postmarketing reports: Hemolytic anemia[Ref]


Rare (less than 0.1%): Blurred vision
Very rare (less than 0.01%): Refraction disorder[Ref]

Refraction disorders have been known to result due to changes in blood glucose levels.[Ref]


Postmarketing reports: Alopecia, Stevens-Johnson syndrome[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Prandin (repaglinide)." Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of Prandin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.