Ozanimod Side Effects
Medically reviewed by Drugs.com. Last updated on April 20, 2020.
For the Consumer
Applies to ozanimod: oral capsule
You should not use ozanimod if you have a serious heart condition such as "AV block" or sick sinus syndrome and no pacemaker, or if you've recently had heart failure, a heart rhythm disorder, chest pain, heart attack, or stroke. You also should not use ozanimod if you have severe untreated sleep apnea.
Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Wait at least 14 days after stopping an MAO inhibitor before you take ozanimod.
Ozanimod can slow your heart rate when you start taking it. Tell your doctor if you have slow heartbeats, chest pain, shortness of breath, feeling like your heart is skipping beats.
You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, aches, tiredness, cough, rash, painful and frequent urination, confusion, neck stiffness, or increased sensitivity to light. Your risk of infection could last for 3 months after you stop taking this medicine.
Get emergency medical help if you have signs of an allergic reaction: hives, rash; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
slow heartbeats, chest pain, shortness of breath, feeling like your heart is skipping beats;
a light-headed feeling, like you might pass out;
cough, new or worsening shortness of breath;
sudden confusion, severe headache, or vision loss;
pounding in your neck or ears;
changes in vision--blurred vision, increased sensitivity to light, seeing an unusual color in your vision, or having a blind spot or shadows in the center of your vision; or
symptoms of infection--fever, tiredness, cough, rash, increased urination, pain or burning when you urinate, neck stiffness, increased sensitivity to light.
Common side effects may include:
high or low blood pressure;
abnormal liver function tests; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to ozanimod: oral capsule
Frequency not reported: Hypersensitivity[Ref]
Uncommon (0.1% to 1%): Herpes zoster
Very common (10% or more): Common (1% to 10%): Back pain[Ref]
Common (1% to 10%): Urinary tract infection[Ref]
Very common (10% or more): Aminotransferase elevations (e.g., alanine aminotransferase increased, gamma-glutamyl transferase increased, aspartate aminotransferase increased, hepatic enzyme increased, liver function test abnormal, transaminases increased) (10%)[Ref]
Very common (10% or more): Upper respiratory tract infection (e.g., nasopharyngitis, upper respiratory tract infection, pharyngitis, respiratory tract infection, bronchitis, rhinitis, respiratory tract infection viral, viral upper respiratory tract infection, rhinorrhea, tracheitis, laryngitis) (26%)
Common (1% to 10%): Dose-dependent reductions in absolute FEV1 and FVC[Ref]
Frequency not reported: Severe exacerbation of disease (e.g., disease rebound)[Ref]
Rare (0.01% to 0.1%): Progressive multifocal leukoencephalopathy (PML)[Ref]
Common (1% to 10%): Hypertension (e.g., hypertension, essential hypertension, orthostatic hypertension)
Uncommon (0.1% to 1%): Bradycardia
Frequency not reported: Atrioventricular conduction delays[Ref]
1. "Product Information. Zeposia (ozanimod)." Celgene Corporation, Summit, NJ.
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More about ozanimod
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: selective immunosuppressants
- Other brands
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.