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Multiple sclerosis

Medically reviewed by Drugs.com. Last updated on Aug 6, 2025.

What is multiple sclerosis?

Harvard Health Publishing

Multiple sclerosis (MS) is a neurological illness that affects the brain and spinal cord. Symptoms of the disease be intermittent (they come and go). Or MS can be progressive. This means it worsens over time.

Nerve cells called neurons send out long "fingers" called axons.  The axons from one neuron send signals to another neuron that may be some distance away. A substance called myelin normally is wrapped around the axons (a bit like insulation around a wire). Myelin helps the axon transmit signals from one neuron to another.

In MS, inflammation damages both the neurons and the myelin. This disrupts or slows nerve signals. The inflammation also leaves areas of scarring called sclerosis.

Multiple sclerosis

The disruption of nerve signals causes a variety of symptoms. MS can affect a person's vision, ability to move parts of the body, and ability to feel sensations such as pain and touch.

In a common type of MS, symptoms usually come and go. Periods when symptoms suddenly get worse are called relapses. They alternate with periods when symptoms improve, called remissions.

Many people have a long history of MS attacks over several decades. In these cases, the disease may worsen in steps, when the attacks occur. For others, the disease worsens steadily. In a minority of patients, MS causes relatively few problems.

Scientists believe MS is an autoimmune disease. This means the immune system mistakenly attacks its own body. In this case, the body attacks the myelin sheaths of the nerves.

Several viruses have been linked to MS, especially Epstein-Barr virus. But there is still no proof that a virus causes the disease. Fever or other physical or emotional stress may contribute to a flare-up of symptoms. The timing, duration, and damage of MS attacks are often unpredictable.

The symptoms of MS usually begin before age 40, but can first appear at an older age. Women are more likely than men to get MS. Having a close relative with MS increases your chances of developing the disease.

Symptoms of multiple sclerosis

Symptoms of MS vary depending on which areas of the brain and spinal cord are affected.

MS can cause

Diagnosing multiple sclerosis

Your doctor will look for signs of neurological problems. These include:

A magnetic resonance imaging (MRI) scan can be helpful to confirm the diagnosis, as it can detect inflammation and myelin sheath destruction in your brain and spinal cord.

Other possible diagnostic tests include:

Expected duration of multiple sclerosis

MS is a lifelong illness. It can follow one of several different patterns.

The three most common patterns seen in MS patients are:

Preventing multiple sclerosis

There is no way to prevent MS.

Treatment options

The following list of medications are related to or used in the treatment of this condition.

View more treatment options

Treating multiple sclerosis

There is no cure for MS.

Nonmedication approaches can improve symptoms. For example, regular exercise may reduce fatigue, and physical therapy can be helpful for muscle spasticity.

Medications may be recommended to treat symptoms of MS, or to modify the immune system to suppress the disease.

Examples of symptoms of MS that can be improved with medication include:

Treatments that act on the immune system to suppress the disease include:

The choice of treatment is a shared decision between you and your doctor, and will depend on the type and severity of symptoms and individual preference.

When to call a professional

Call your doctor immediately if you have symptoms of MS.

Prognosis

A minority of people with MS have a relatively harmless form of the illness. But the majority of patients suffer from neurological disability over time.

MS is usually a progressive illness that can last for decades. The degree of progression and eventual disability varies from patient to patient. Newer treatments have improved the prognosis for people with MS.

Additional info

National Multiple Sclerosis Society
http://www.nationalmssociety.org/

Multiple Sclerosis Foundation
http://msfocus.org/


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