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Ocrevus User Reviews & Ratings

Ocrevus has an average rating of 5.0 out of 10 from a total of 166 reviews on Drugs.com. 39% of reviewers reported a positive experience, while 47% reported a negative experience.

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Multiple Sclerosis  
5.0
166 reviews for Multiple Sclerosis 101 medications
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Reviews for Ocrevus

  • FD32
  • Taken for 1 to 2 years
  • June 3, 2021

For Multiple Sclerosis "When Ocrevus first came out, it was practically touted as a ‘miracle drug,’ and it seemed like everyone with MS wanted to get on it. I had such high hopes when I read that not only did it do a great job in reducing relapses and new brain lesions, it significantly slowed progression and even dramatically improved a lot of patients’ symptoms. Well, in the almost two years I’ve been on it, all it has done for me is make my walking a heck of a lot worse. Prior to Ocrevus, I used to enjoy going on hiking trails even though I used a cane. Now I can barely hobble around my backyard. Rather than slowing down progression, it seems to have sped mine up. I fear that if I continue to stay on it, the day will come when I won’t be able to walk at all anymore. Really disappointed and disgusted by this drug."

1 / 10
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  • Joan
  • October 17, 2019

For Multiple Sclerosis "I have had two half doses of Ocrevus, and my fatigue is almost totally gone. I felt a difference right away. Seems like it improved on the very first day. I have RRMS. All my functioning seems to have improved. I was on Tecfidera for 3.5 years, and it went well, but had to stop. Tried Aubagio, reacted, had to stop. When Aubagio was all gone, tried Ocrevus. Relief! Without Ocrevus, my left leg was starting to drag, fatigue was strong, walking was harder, trouble with cognition and memory. The first day after infusion with Ocrevus, I felt a difference, almost like I don't have MS. Reading all these reviews, I wonder if there are types of MS that respond better than others. It is interesting to see some people have no help with Ocrevus and others feel better. I am glad I am one that is better. All the best to anyone fighting MS; it's no picnic. Wish everybody well."

9 / 10
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  • Jenn
  • Taken for 1 to 2 years
  • August 30, 2019

For Multiple Sclerosis "I need to write this review because I am so surprised how many bad reviews there are for this drug. This drug has changed my life! I started treatment by taking Rituximab for 1 year. After the year, they switched me to Ocrevus. I haven't had any attacks in 2 years. I was diagnosed with RRMS when I was just 17 years old. For 6 years after, I was having 2-3 extreme attacks per year. Since this treatment, I have so much energy and can do so many things I couldn't before. This drug has been the biggest blessing."

10 / 10
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Frequently asked questions

  • Anonymous
  • Taken for 1 to 6 months
  • July 20, 2019

For Multiple Sclerosis "For me, having MS for 20 years. Going downhill quickly in the last three years and already been on three treatments: Rebif, Copaxone, and Gilenya. Hope was lost until now. This drug is a game-changer for me. Mobility has improved so much that I am forgetting about my MS. Enjoying life with my family, and for the first time in years, I have hope."

10 / 10
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  • Becca...
  • July 8, 2021

For Multiple Sclerosis "It's been 20 hours since my first infusion. My ears and hair follicles itched, and Benadryl knocked this out. I also had a slight difficulty swallowing. My calves started having severe spasticity and pains, but after 30 minutes, this was gone. Had some throat scratchiness, like that of starting to get a cold, but this was gone in 2 hours. I was diagnosed in 2003 with RRMS. I was in high school. Lost feeling in all fingertips and toes. I experience optic neuritis daily (have lost some sight in right eye). Balance, gait, thinking, depression, FATIGUE. I am 36. I have PPMS now. Been on Copaxone, Avonex, Plegridy. I quit working in March 2020. Then Covid, and I went into isolation. I take primatene meant for intermittent asthma but it's ephedrine. It really helps with FATIGUE. Give it time. Remember MS is a beast, and not every drug will help everyone. My best advice for MS: comedy, sleep, and acceptance. It stinks, but remember. You choose how you can react."

7 / 10
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Are you taking this medicine?

  • Grey
  • Taken for 1 to 6 months
  • January 15, 2020

For Multiple Sclerosis "People need to stop being so negative on here. It isn't helpful to anyone. We all have MS; it is never going to be easy. Moaning all the time, look for positives in your life. I have had MS for 10 years, 7 years on Tysabri. Now switched to Ocrevus, had first 2 doses. Not doing great, but it is early days. It is the long-term effects of this treatment that you will notice. It is 5 years + to notice any great benefit. Hang in there, all of you, it will improve. Be patient."

8 / 10
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  • Jess
  • October 15, 2020

For Multiple Sclerosis "I was diagnosed RRMS about a decade ago, and I'm currently in my early 30s. I finished the second of my first 2 infusions a few weeks back. So I can't really attest to how effective the drug will be long term. What I can attest to is that before I started it, I was really concerned. It's all too easy to read online and get worried about potentially severe side effects and infusion reactions. I figure most people don't report when nothing goes wrong. So that's what I want to do. I started my first infusion, got my premedication for which I had no side effects. The only infusion side effect I had was a slightly odd sensation in the back of my throat near the end of the infusion, which quickly went away after finishing. In my second infusion, I had no side effects whatsoever. And from then until now, I honestly wouldn't even have known I had it. I'm optimistic and very glad I didn't let my fears get the better of me. Your experience may vary, of course."

10 / 10
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More FAQ

  • Jan...
  • August 24, 2019

For Multiple Sclerosis "Weird: I was RRMS (relapsing-remitting multiple sclerosis) and my neuro was so giddy about this drug that she even used the big C word (cure) with it. I did 4 infusions and what did I get for my loyalty and trust of my neuro: I am now Secondary-progressive multiple sclerosis (SPMS). I declined so fast and drastically after taking this poison that I was re-diagnosed and I said 'What the... you promised me this would basically cure me'. Tough luck, they said. I also learned that the 'neuro' in question received 260K in 'appearance' fees from Biogen. Just google openpaymentsdata and see how much your doctor is getting paid! AWESOME!!! He makes money. I suffer. Go in fully woke on this one folks."

1 / 10
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  • KPano
  • Taken for 1 to 2 years
  • May 29, 2019

For Multiple Sclerosis "I've been on Ocrevus for exactly one year. Going for my fourth injection next week. This drug has been a game changer for me. I had my MRI last month and NO NEW LESIONS, and we are seeing that old lesions are no longer showing up at all on MRI with and without contrast. Nothing is active. This drug is a breeze compared to 14 years of Avonex, then a bad reaction to Copaxone (I'm allergic), and a horrible experience with Tecfidera. I have had zero side effects from taking this medication after the infusion. During infusion, my throat got a little scratchy, that was it, and that disappeared as fast as it started and only happened on my very first half dose last year. This is not a cure. This drug acts just like all the other MS treatments... to try and slow disease progression. I find it awful that people are bashing this medication after just one or two doses. This drug has been a game changer for me."

10 / 10
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  • Betsy
  • July 21, 2020

For Multiple Sclerosis "Ocrevus almost finished off my sister. After a second infusion, she was hospitalized in a near-catatonic state and suffering from severe neurological effects. She had hallucinations, a heart attack, and nearly died. FDA should never have approved this drug without more testing. Strongly advise against taking Ocrevus. The effects of MS are less severe than the effects of Ocrevus. Do not allow a physician to upsell you on this lethal treatment."

1 / 10
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  • Aisha
  • April 11, 2020

For Multiple Sclerosis "Diagnosed RRMS in 2011. Been on Rebif, Tecfidera. Started my first two halves of Ocrevus in May 2019. I had less fatigue. I did notice I became more clumsy. Told my doctor. He said to keep taking it; it will get better. First full dose in October 2019, the clumsiness got even worse. I can't lift my feet. I went from lightly walking with a cane before Ocrevus to using a rollator. It does work for a lot of people, but people need to realize that a small percentage of us are becoming more disabled. I called the company and asked them about their trial. They said there is a small few that have problems with walking. It took me forever to find this page to figure out that I was not going crazy; something was really wrong. I have a new neurologist now that wants to say that I have progressed to SPMS, but I'm telling him to hold on. Does this drug make you progress, or do you have to wait for this to wear off? Anyone, when you stop taking it, do you ever get better with walking, and how long does it take."

1 / 10
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  • PMC
  • Taken for 6 months to 1 year
  • June 30, 2020

For Multiple Sclerosis "Ocrevus has hastened my demise: one new lesion, intense tingling in my neck and no strength. All of these deficiencies occurred in one year - the same year I was on Ocrevus. What is going on? How did this happen? The drug was supposed to help me, not hurt me. I do not believe any of the data from the testing. I am angry."

1 / 10
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  • Reza
  • Taken for 1 to 2 years
  • January 4, 2021

For Multiple Sclerosis "I was diagnosed with PPMS in January 2018 and my neurologist put me on OCREVUS. At the time of diagnosis of MS, I just had a little numbness in my left hand and a little weakness in my right leg. Now, after two years and three OCREVUS infusions, which were supposed to help slow down the disease progression, unfortunately, I am using a walker for walking at home due to a lack of balance, too much spasticity, weakness, numbness, bladder issues, and low back and neck pains! I believe this drug has destroyed my life. I think if I hadn't used this drug, my MS disease would not have progressed to this level. But I felt I had no other choice because my neurologist said this is the only medication for PPMS! Please be cautious when considering this medication."

1 / 10
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  • Nina
  • June 28, 2020

For Multiple Sclerosis "Ocrevus is a monster!! I have RRMS that is very aggressive. Three treatments later, I have absolutely NO quality of life. Side effects from this poison were not in the 'brochure' I received from my neurologist. Only the ones regarding initial ones at the time of infusion. More common side effects, I have 18 out of 24; Less Common, 2 out of 3; More Common, 9 out of 11. I started out using a forearm crutch, now a wheelchair. My cognitive skills have plummeted. I have no interest in anything, my passion was my art. Painting, designing, I feel flat, void of emotion. The ironic part is that I have no new lesions. I have decided not to take it; I will be taking Copaxone. I hope and pray the side effects will go away. I don't understand how a medication that does this is even on the market. Four point five out of 10 is not good odds. I haven't found any group or site that has good reviews that outweigh the bad. MS IS BAD ENOUGH; now mine is WORSE!"

1 / 10
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  • DMC
  • Taken for 1 to 6 months
  • August 2, 2020

For Multiple Sclerosis "This was my second try for Ocrevus because the doctor wanted me on a treatment for MS. Guess what? I quickly know and remember now why I didn't want to be on this or continue with Ocrevus! Since my infusion on 6/29/20, I have felt terrible: severe fatigue, on and off depression, severe muscle aches at the back of both upper legs... trouble walking, feet sticking to floor causing falls or slides on carpet, headaches, and some cognitive issues on and off. So tired even after some sleep at nighttime. MS stinks, but when taking something that's supposed to help causing worse issues than began with, it really is more than stinks, it sucks! I definitely will not go on this ever again... just hoping this gets out of my system soon!"

1 / 10
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  • Sherly...
  • Taken for 1 to 2 years
  • April 8, 2019

For Multiple Sclerosis "I went on this DMD after my neurologist suggested I read the 'glowing reviews' on YouTube and this place on Reddit called /r/Multiple Sclerosis. I did all the infusions, and a year later, I went from mild RRMS to a very aggressive RRMS. What happened? Why did this happen? The smug doctor said 'it can happen to a small percentage of people'. What? You tell me after I take this horrible treatment? I should have been informed before. Is it true that neurologists are paid 'appearance fees' by this manufacturer to push this drug? I also learned that in /r/Multiple Sclerosis on some of the comment sites (but not this one), people are paid to push this drug, so be careful what you read. Talk to people you meet at the clinics for advice."

1 / 10
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  • Car
  • Taken for 1 to 2 years
  • July 5, 2021

For Multiple Sclerosis "Unfortunately, Ocrevus made all of my MS symptoms worse and even gave me some new symptoms. I was on Ocrevus for 3 infusions (1.5 years) After one year of being off of Ocrevus, I am back to my baseline. This drug gave me incredibly bad pain - muscles and joints, including Trigeminal Neuralgia (never had it before O and it's gone now). I felt nauseous on this drug, had horrible migraines, and the weakness in my legs increased. It also gave me cystic acne. I am much better now that my WBC is back up, but it took a whole year for my labs to normalize and to feel better. I thought it was an awful drug, but everyone is different! I had no new lesions, but I did progress and feel worse than before I started taking it. I will say that the neuro didn't report my adverse effects even though I was on a clinical study- so I am wondering if they only report lesion activity."

1 / 10
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  • MPano
  • Taken for 2 to 5 years
  • August 24, 2019

For Multiple Sclerosis "My husband is 29 and was diagnosed with Primary-progressive multiple sclerosis (PPMS) in 2017 and has been having the Ocrevus every 6 months since. His MRIs have shown no progression - stable - and although he has not improved a huge amount, every little bit of progress is amazing! He can go on longer walks, his vertigo is slightly improving, and overall he seems to be doing better than he was before the Ocrevus. He only had one side effect during the infusion, which was red itchy ears and an itch in his throat, but with some Benadryl he was good to go. We are thankful for Ocrevus."

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  • Lique2u
  • Taken for less than 1 month
  • September 9, 2020

For Multiple Sclerosis "AFTER just having ONE Ocrevus infusion, MY experience is as follows: I will NOT take this drug EVER again!!! WHY???? The two big toes on my feet are black and falling off, the joints on my hands, ankles, fingers and knees hurt, I have extreme fatigue, the knuckles on both hands are black, and I can no loner bend my legs!!!!!!"

1 / 10
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  • LCano
  • Taken for 1 to 2 years
  • May 18, 2019

For Multiple Sclerosis "Diagnosed in 2015 after a major flare-up of multiple sclerosis (MS) with multiple active lesions on the brain, neck, and spine. Tried Avonex, Tecfidera, and Copaxone but still continued progressing with new lesions. Started Ocrevus in November 2017 and have had no new MS disease activity since; it is working! I've had 2 half infusions and 3 full infusions since starting. Less fatigue, fewer muscle spasms, fewer cognitive problems, better balance; overall, I've just felt great since starting."

10 / 10
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  • Mandy
  • Taken for 2 to 5 years
  • April 15, 2023

For Multiple Sclerosis "I was on Ocrevus for 3 years, so essentially 6 infusions I believe. I was dx with MS in 2005 when 21 years old, and failed most of the baseline MS drugs due to side effects. I had a stint of no medications for 7 years with stable MRIs but my neurologist convinced me to try Ocrevus since it seemed convenient to just 2 infusions a year. The first few infusions were rough; I experienced really bad inner bone aching. My arms and legs just felt like a toothache. My neurologist said he never heard of this and said it was unrelated. I disagreed. 2 years in, I had 3 teeth randomly crack while eating, needing crowns. Again, my neurologist said it was unrelated to the Ocrevus. By year 3, the hair loss, fatigue, and overall feeling of body weakness has gotten worse so I decided to skip an infusion to see if it is the Ocrevus making me feel sickly…. 8 months since my last infusion and I’m finally starting to feel human again like I did before starting."

3 / 10
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  • Tyano
  • Taken for 6 months to 1 year
  • June 6, 2019

For Multiple Sclerosis "I was diagnosed with MS at the age of 56, in Jan of this year. I was approved to try the new drug OCREVUS and I have to say this new drug is a 100% game changer for anyone with MS. It has been a complete turnaround with my balance and mobility; this is the best that I've felt in years. Thank you, OCREVUS. Tyrome"

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  • Itget...
  • Taken for 6 months to 1 year
  • December 15, 2019

For Multiple Sclerosis "I have PPMS and have been using Ocrevus for about 1 year as of this Friday. I notice my walking is worsening, and I think I'm relapsing now. Ocrevus does not work; it's only made me worse. Don't believe what you hear, read, or see. Someone, please pray for and with me."

1 / 10
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88 Report
  • slim...
  • September 21, 2019

For Multiple Sclerosis "I started Ocrevus in July of 2018. I have had three treatments, and I am now worse than I have ever been with MS! My balance is completely shot, I have pain I never had before, tightness and paralysis in my left leg, stumbling much more, can hardly pick up my feet, chest pain issues, headaches, and cloudy thinking problems! This drug was pushed on me by my neurologist despite me not wanting it because he said it was the best thing out. Now I know it was the best thing for his pocket and not my health! DONE with Ocrevus!"

1 / 10
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  • Tough...
  • Taken for 1 to 6 months
  • December 16, 2020

For Multiple Sclerosis "I've had MS for 29 years. No relapses for a while, no worsening MRIs for a long time. So it would seem I'm in secondary progressive stage. I was on Tecfedera since the week it was approved by the FDA, about 10 years ago. But I've been declining slowly with the usual MS stuff - fatigue, cognitive, walking is slow, right side is weak, and falling. So I decided I wanted to get more aggressive with my treatment than my neurologist was willing to, so I switched to another neurologist knowing he would put me on Ocrevus. I had 2 first time infusions about 5 weeks ago. Well now I'm scared. Since then I had complete numbness on right side for about 24 hours but it did go away. Bladder has never been as bad as it is now. I feel like I have numbness traveling from foot to foot, hands, back, stomach. I'm pretty nervous. Thinking I might have made a mistake,"

5 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.