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How long does it take Ocrevus to work?

Medically reviewed by Carmen Fookes, BPharm. Last updated on Aug 12, 2020.

Official Answer


Ocrevus starts to work within about 12 weeks; however, it may take a few years for the full effects to be seen. Trials have shown that:

  • By 12 weeks, Ocrevus had significantly lowered the number of relapses per year by 46 to 47% in people with relapsing multiple sclerosis (RMS) compared with REBIF (interferon beta-1a)
  • 82% to 83% of people taking Ocrevus were relapse-free after 12 weeks compared with 71% to 72% of people assigned to REBIF
  • 9.8% of Ocrevus patients were shown to have disability progression compared with 15.2% of REBIF patients after 96 weeks
  • The time to onset of disability progression was significantly longer for Ocrevus-treated patients than for placebo-treated patients (a 24% reduction in the time to confirmed disability progression noted at 24 weeks which persisted for the study duration which was 216 weeks).
  • Ocrevus (ocrelizumab) 05/2020 Genentech, Inc.
  • Ocrevus. National Multiple Sclerosis Society. 2020,primary%20progressive%20MS%20in%20adults.

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