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How long does it take Ocrevus to work?

Medically reviewed by Carmen Fookes, BPharm. Last updated on Aug 12, 2020.

Official Answer

by Drugs.com

Ocrevus starts to work within about 12 weeks; however, it may take a few years for the full effects to be seen. Trials have shown that:

  • By 12 weeks, Ocrevus had significantly lowered the number of relapses per year by 46 to 47% in people with relapsing multiple sclerosis (RMS) compared with REBIF (interferon beta-1a)
  • 82% to 83% of people taking Ocrevus were relapse-free after 12 weeks compared with 71% to 72% of people assigned to REBIF
  • 9.8% of Ocrevus patients were shown to have disability progression compared with 15.2% of REBIF patients after 96 weeks
  • The time to onset of disability progression was significantly longer for Ocrevus-treated patients than for placebo-treated patients (a 24% reduction in the time to confirmed disability progression noted at 24 weeks which persisted for the study duration which was 216 weeks).
References
  • Ocrevus (ocrelizumab) 05/2020 Genentech, Inc. https://www.drugs.com/pro/ocrevus.html
  • Ocrevus. National Multiple Sclerosis Society. 2020 https://www.nationalmssociety.org/Treating-MS/Medications/Ocrevus#:~:text=Ocrevus%20is%20approved%20by%20the,primary%20progressive%20MS%20in%20adults.

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