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Ocrevus Side Effects

Generic Name: ocrelizumab

Note: This document contains side effect information about ocrelizumab. Some of the dosage forms listed on this page may not apply to the brand name Ocrevus.

In Summary

Common side effects of Ocrevus include: lower respiratory tract infection, upper respiratory tract infection, cough, and infusion related reaction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ocrelizumab: intravenous solution

Along with its needed effects, ocrelizumab (the active ingredient contained in Ocrevus) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ocrelizumab:

More common
  • Back pain
  • blurred vision
  • body aches or pain
  • chest tightness
  • chills
  • confusion
  • cough
  • difficulty with breathing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • fast, pounding, or irregular heartbeat or pulse
  • feeling of warmth
  • fever
  • headache
  • hives, itching, or skin rash
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • loss of voice
  • nasal congestion
  • nausea and vomiting
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • sneezing
  • sore throat
  • sweating
  • trouble breathing
  • unusual tiredness or weakness
Less common
  • Burning or stinging of the skin
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
Incidence not known
  • Convulsions
  • drowsiness

Some side effects of ocrelizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • diarrhea
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • rapid weight gain
  • tingling of the hands or feet
  • trouble concentrating
  • trouble sleeping
  • unusual weight gain or loss

For Healthcare Professionals

Applies to ocrelizumab: intravenous solution

Respiratory

Very common (10% or more): Upper respiratory tract infection (up to 49%)
Common (1% to 10%): Lower respiratory tract infection[Ref]

Psychiatric

Common (1% to 10%): Depression[Ref]

Oncologic

Uncommon (0.1% to 1%): Breast cancer[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, pain in extremity[Ref]

Local

Very common (10% or more): Infusion reactions (up to 40%)[Ref]

Immunologic

Common (1% to 10%): Herpes virus associated infections
Frequency not reported: Immunogenicity[Ref]

Hematologic

Very common (10% or more): Neutrophil levels decreased (13%)[Ref]

Dermatologic

Very common (10% or more): Skin infections (up to 14%)[Ref]

References

1. "Product Information. Ocrevus (ocrelizumab)." Genentech, South San Francisco, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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