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Monovisc Side Effects

Generic name: hyaluronan

Note: This document contains side effect information about hyaluronan. Some dosage forms listed on this page may not apply to the brand name Monovisc.

Applies to hyaluronan: intra-articular gel, intra-articular solution.


You should not receive hyaluronan if you have a bleeding disorder, certain allergies, or an infection in your knee or in the skin around your knee.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • bleeding;

  • increased knee pain; or

  • signs of infection (warmth, swelling, redness) around your knee.

Common side effects may include:

  • joint pain, stiffness, or swelling;

  • itching, numbness, or tingling;

  • headache, dizziness;

  • back pain;

  • swelling, pain, redness, or mild discomfort where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to hyaluronan: intra-articular gel, intra-articular solution.


Uncommon (0.1% to 1%): Injection site erythema, injection site edema[Ref]


Very common (10% or more): Arthralgia (13%)

Common (1% to 10%): Arthritis, back pain

Uncommon (0.1% to 1%): Arthropathy, joint disorder, joint effusion, joint stiffness, joint swelling, aggravated osteoarthritis, localized osteoarthritis, knee arthroplasty[Ref]


Uncommon (0.1% to 1%): Baker's cyst, bursitis[Ref]

Nervous system

Very common (10% or more): Headache (12%)[Ref]


Uncommon (0.1% to 1%): Erythema, edema[Ref]

Frequently asked questions


1. Product Information. Orthovisc (hyaluronan). Ortho Biotech Inc. 2004.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.