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Generic name: hyaluronanHYE-al-URE-oh-nan ]
Brand names: Hymovis, Monovisc, Orthovisc
Drug class: Viscosupplementation agents

Medically reviewed by on Nov 20, 2023. Written by Cerner Multum.

What is Hymovis?

Hymovis is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints.

Hymovis is used to treat knee pain caused by osteoarthritis.

Hymovis is usually given after other arthritis medications have been tried without success.

Hymovis may also be used for purposes not listed in this medication guide.

Hymovis side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Hymovis may cause serious side effects. Call your doctor at once if you have:

Common side effects of Hymovis may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not receive Hymovis if you have a bleeding disorder, certain allergies, or an infection in your knee or in the skin around your knee.

Before taking this medicine

You should not be treated with Hymovis if you are allergic to it, or if you have:

It is not known whether Hymovis will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Hymovis.

It is not known whether hyaluronan passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Hymovis is not approved for use by anyone younger than 21 years old.

How is Hymovis given?

Hymovis is injected directly into your knee joint. A healthcare provider will give you this injection.

You may be given more than one Hymovis injection. If so, additional injections are usually given at least 1 week after your first injection.

Follow your doctor's dosing instructions very carefully.

This medicine should give you relief from pain for several months.

Tell your doctor if your symptoms do not improve, or if they get worse.

What happens if I miss a dose?

Since Hymovis is usually given in a single dose, it does not have a daily dosing schedule.

If you need to receive more than one Hymovis injection, call your doctor for instructions if you miss your next injection appointment.

What happens if I overdose?

Since Hymovis is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving Hymovis?

For at least 48 hours after your injection: Avoid jogging, strenuous activity, or high-impact sports such as tennis. Also avoid weight-bearing activity or standing for longer than 1 hour at a time.

What other drugs will affect Hymovis?

Other drugs may interact with hyaluronan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.