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Molindone Side Effects

Applies to molindone: oral syrup, oral tablet

In addition to its needed effects, some unwanted effects may be caused by molindone. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking molindone:

More common:
  • Difficulty with talking or swallowing
  • inability to move the eyes
  • lip smacking or puckering
  • loss of balance control
  • mask-like face
  • muscle spasms, especially of the neck and back
  • puffing of the cheeks
  • rapid or worm-like movements of the tongue
  • restlessness or need to keep moving (severe)
  • shuffling walk
  • stiffness of the arms and legs
  • trembling and shaking of the hands
  • twisting movements of the body
  • uncontrolled movements of the arms and legs
  • unusual chewing movements
Less common:
  • Discouragement
  • false or unusual sense of well-being
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • tiredness
  • trouble sitting still
  • trouble with concentrating
  • trouble with sleeping
  • Blurred vision
  • confusion
  • dark-colored urine
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • general feeling of tiredness or weakness
  • headache
  • hot, dry skin, or lack of sweating
  • light-colored stools
  • muscle weakness
  • skin rash
  • stomach pain, continuing
  • sweating
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin
Incidence not known:
  • Absence of or decrease in body movement
  • decrease in frequency of urination
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • fast, pounding, or irregular heartbeat or pulse
  • increased blinking or spasms of the eyelid
  • painful urination
  • slowed movements
  • sticking out of the tongue
  • tic-like (jerky) movements of the head, face, mouth, and neck
  • trouble with breathing, speaking, or swallowing
  • twisting movements of the neck, trunk, arms, or legs
  • unusual facial expressions

Severity: Minor

Some of the side effects that can occur with molindone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Constipation
  • decreased sweating
  • difficult urination
  • drowsiness
  • dryness of the mouth
  • headache
  • nausea
  • stuffy nose
Less common:
  • Absent, missed, or irregular menstrual periods
  • changes in menstrual periods
  • decreased sexual ability
  • false sense of well-being
  • stopping of menstrual bleeding
  • swelling of the breasts or breast soreness in both females and males
  • unexpected or excess milk flow from breasts
  • unusual secretion of milk
Incidence not known:
  • Decreased interest in sexual intercourse
  • inability to have or keep an erection
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • loss in sexual ability, desire, drive, or performance
  • painful or prolonged erection of the penis
  • weight gain or loss

Not all side effects for molindone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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