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Molindone Dosage

Applies to the following strengths: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 20 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Schizophrenia

Initial Dosing Schedule:
-Recommended dose: 50 to 75 mg orally per day, increasing the dose to 100 mg/day in 3 to 4 days
-Maximum dose: 225 mg/day

Maintenance Dosing Schedule:
-Mild symptomology: 5 to 15 mg orally 3 to 4 times a day
-Moderate symptomology: 10 to 25 mg orally 3 to 4 times a day
-Severe symptomology: Up to 225 mg/day

Comments:
-Patients with severe symptomology may require 225 mg/day.
-Elderly and/or debilitates patients should begin on the lower dosage.

Use: Management of schizophrenia

Usual Pediatric Dose for Schizophrenia

12 to 18 years:
Initial Dosage Schedule:
-Recommended dose: 50 to 75 mg orally per day, increasing the dose to 100 mg/day in 3 to 4 days
-Maximum dose: 225 mg/day

Maintenance Dosing Schedule:
-Mild symptomology: 5 to 15 mg orally 3 to 4 times a day
-Moderate symptomology: 10 to 25 mg orally 3 to 4 times a day
-Severe symptomology: Up to 225 mg/day

Comments:
-Patients with severe symptomology may require 225 mg/day.
-Debilitated patients should begin on the lower dosage.

Use: Management of schizophrenia

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNING:
-INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS: This drug has an increased risk of mortality when administered to elderly patients with dementia-related psychosis. Elderly patients with dementia-related psychosis treated with antipsychotic drugs have an increased risk of death. This drug is not approved for use in patients with dementia-related psychosis.

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-See manufacturer product information.

Storage requirements:
-See manufacturer product information.

General:
-Effectiveness was determined in clinical studies with newly hospitalized and chronically hospitalized, acutely ill patients with schizophrenia.
-This drug has not been shown effective in the management of behavioral complications in patients with mental impairment.

Monitoring:
-Complete blood count before and periodically during treatment

Patient advice:
-Warn patients to avoid abrupt discontinuation of this drug.
-Tell patients to immediately report any signs/symptoms of neutropenia/leukopenia, neuroleptic malignant syndrome, or tardive dyskinesia.
-Patients should be advised to report all concurrent prescription and nonprescription medications or herbal products they are taking.
-Inform patients that this drug may cause drowsiness, and they should avoid driving or operating machinery until the full effects of the drug are known.
-Patients should be advised to speak to a healthcare provider if they are pregnant, intend to become pregnant, or are breastfeeding.

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