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Meclomen Side Effects

Generic name: meclofenamate

Medically reviewed by Drugs.com. Last updated on May 21, 2023.

Note: This document contains side effect information about meclofenamate. Some dosage forms listed on this page may not apply to the brand name Meclomen.

Applies to meclofenamate: oral capsule.

Warning

Oral route (Capsule)

Cardiovascular Thrombotic EventsNonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use.Meclofenamate sodium capsules are contraindicated in the setting of coronary artery bypass graft (CABG) surgery.Gastrointestinal RiskNSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events.

Serious side effects of Meclomen

Along with its needed effects, meclofenamate (the active ingredient contained in Meclomen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking meclofenamate:

More common

Less common

Rare

Other side effects of Meclomen

Some side effects of meclofenamate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Rare

For Healthcare Professionals

Applies to meclofenamate: compounding powder, oral capsule.

General

The most frequently reported side effects were gastrointestinal in nature and included diarrhea, nausea with or without vomiting, and abdominal pain.[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 33%), nausea (11%)

Common (1% to 10%): Vomiting, abdominal pain, pyrosis, flatulence, constipation, stomatitis, peptic ulcer

Frequency not reported: Colitis, bleeding, perforation, ulcer, paralytic ileus[Ref]

Dermatologic

Common (1% to 10%): Rash, urticaria, pruritus

Frequency not reported: Erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, erythema nodosum, hair loss[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Frequency not reported: Paresthesia, taste disturbance[Ref]

Other

Common (1% to 10%): Edema, tinnitus

Frequency not reported: Malaise, fatigue[Ref]

Cardiovascular

Frequency not reported: Palpitations[Ref]

Hematologic

Frequency not reported: Neutropenia, thrombocytopenic purpura, leukopenia, agranulocytosis, hemolytic anemia, eosinophilia, hemoglobin decreased, hematocrit decreased[Ref]

Hepatic

Frequency not reported: Liver function tests abnormal, cholestatic jaundice[Ref]

Renal

Frequency not reported: Renal failure[Ref]

Metabolic

Common (1% to 10%): Anorexia[Ref]

Ocular

Frequency not reported: Vision blurred, visual acuity decreased, temporary vision loss, reversible color vision loss, macular fibrosis, macular edema, perimacular edema, conjunctivitis, iritis[Ref]

Psychiatric

Frequency not reported: Depression, insomnia[Ref]

Genitourinary

Frequency not reported: Nocturia[Ref]

Musculoskeletal

Frequency not reported: Lupus-like syndrome[Ref]

Immunologic

Frequency not reported: Serum sickness-like syndrome

References

1. Product Information. Meclofenamate Sodium (meclofenamate). Mylan Pharmaceuticals Inc. 2012.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.