Margenza Side Effects

Generic name: margetuximab

Medically reviewed by Drugs.com. Last updated on Sep 21, 2023.

Note: This document contains side effect information about margetuximab. Some dosage forms listed on this page may not apply to the brand name Margenza.

Applies to margetuximab: intravenous solution.

Warning

Intravenous route (Solution)

Warning: Left Ventricular Dysfunction and Embryo-fetal ToxicityLeft Ventricular Dysfunction: Margetuximab-cmkb may lead to reductions in left ventricular ejection fraction (LVEF). Evaluate cardiac function prior to and during treatment. Discontinue margetuximab-cmkb treatment for a confirmed clinically significant decrease in left ventricular function.Embryo-fetal Toxicity: Exposure to margetuximab-cmkb during pregnancy can cause embryo-fetal harm. Advise patients of the risk and need for effective contraception.

Serious side effects of Margenza

Along with its needed effects, margetuximab (the active ingredient contained in Margenza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking margetuximab:

More common

Back pain
chest pain or tightness
chills
cough
decreased urine output
difficulty in moving
dilated neck veins
fever
flushing
headache
irregular breathing
irregular heartbeat
muscle aches, cramps, pain, or stiffness
nausea and vomiting
pain in the joints
redness, swelling, pain of the skin
scaling of the skin on the hands and feet
swelling of the face, fingers, feet, or lower legs
swollen joints
tingling of the hands and feet
trouble breathing
ulceration of the skin
unusual tiredness or weakness
weakness
weight gain

Other side effects of Margenza

Some side effects of margetuximab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Arm or leg pain
burning, numbness, tingling, or painful sensations
constipation
decreased appetite
diarrhea
hair loss, thinning of hair
stomach pain
unsteadiness or awkwardness
weakness in the arms, hands, legs, or feet

For Healthcare Professionals

Applies to margetuximab: intravenous solution.

Hematologic

Very common (10% or more): Decreased hemoglobin (52%;), decreased leukocytes (40%), decreased lymphocytopenia (31%), increased INR (24%;), increased aPTT (32%)

Common (1% to 10%): Febrile neutropenia (1.5%), neutropenia/neutrophil count decrease (1.5%)^[Ref]

Immunologic

Common (1% to 10%): Immunogenicity (1.7%)^[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (14%), arthralgia (14%), extremity pain (11%)^[Ref]

Hepatic

Very common (10% or more): Increased serum alanine aminotransferase (32%), increased serum aspartate aminotransferase (23%), increased serum alkaline phosphatase (21%)^[Ref]

Respiratory

Very common (10% or more): Cough (14%), dyspnea (13%)

Uncommon (0.1% to 1%): Aspiration pneumonia (0.4%), viral pneumonia(0.8%)^[Ref]

General

Very common (10% or more): Fatigue/Asthenia (57%), pyrexia (19%), infusion related reaction (13%)

Common (1% to 10%): Fatal adverse reactions (1.1%)^[Ref]

Nervous system

Very common (10% or more): Headache (19%), peripheral neuropathy (16%)

Common (1% to 10%): Dizziness (10%), insomnia (6%)^[Ref]

Renal

Very common (10% or more): Increased serum creatinine (68%)^[Ref]

Cardiovascular

Common (1% to 10%): Hypertension (5%), left ventricular dysfunction (1.9%), syncope (1.5%)^[Ref]

Dermatologic

Very common (10% or more): Alopecia (18%), palmar-plantar erythrodysesthesia (13%)

Common (1% to 10%): Skin rash (6%)^[Ref]

Endocrine

Common (1% to 10%): Decreased weight (6%), increased serum lipase (30%),^[Ref]

Gastrointestinal

Very common (10% or more): Abdominal pain (17%), constipation (19%), increased serum lipase (30%), decreased appetite (14%), nausea (33%), vomiting (21%), diarrhea (25%)

Common (1% to 10%): Dysgeusia (6%), stomatitis (10%)^[Ref]