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HER2 inhibitors

What are HER2 inhibitors?

Human epidermal growth factor receptor (HER2) inhibitors are either tyrosine kinase inhibitors or monoclonal antibodies that slow down or stop cell growth.

Human epidermal growth factor receptors are transmembrane receptors; they have an extracellular binding component, a transmembrane component and an intracellular tyrosine kinase component. Some breast cancers have an over-expression of HER2 resulting in increased cell growth and spread of cancer cells.

Tyrosine kinase inhibitors bind to the tyrosine kinase domain in the HER2 and stops activation of the signaling pathway. Monoclonal antibodies bind to the extracellular component of the HER2, prevent the actual substrates from binding to the receptors and stop the receptor activation.

HER2 inhibitors are used in the treatment of breast cancer.

List of HER2 inhibitors

View by  Brand | Generic
Drug Name Avg. Rating Reviews
Nerlynx (Pro)
Generic name: neratinib
19 reviews
Enhertu (Pro)
Generic name: fam-trastuzumab deruxtecan
13 reviews
Herceptin (Pro)
Generic name: trastuzumab
12 reviews
Herceptin Hylecta (Pro)
Generic name: hyaluronidase / trastuzumab
1 review
Vizimpro (Pro)
Generic name: dacomitinib
No reviews
Tykerb (Pro)
Generic name: lapatinib
No reviews
Tukysa (Pro)
Generic name: tucatinib
No reviews
Trazimera (Pro)
Generic name: trastuzumab
No reviews
Phesgo (Pro)
Generic name: hyaluronidase / pertuzumab / trastuzumab
No reviews
Perjeta (Pro)
Generic name: pertuzumab
No reviews
Ontruzant (Pro)
Generic name: trastuzumab
No reviews
Ogivri (Pro)
Generic name: trastuzumab
No reviews
Margenza (Pro)
Generic name: margetuximab
No reviews
Kadcyla (Pro)
Generic name: ado-trastuzumab emtansine
No reviews
Herzuma (Pro)
Generic name: trastuzumab
No reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.