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HER2 inhibitors

What are HER2 inhibitors?

Human epidermal growth factor receptor (HER2) inhibitors are either tyrosine kinase inhibitors or monoclonal antibodies that slow down or stop cell growth.

Human epidermal growth factor receptors are transmembrane receptors; they have an extracellular binding component, a transmembrane component and an intracellular tyrosine kinase component. Some breast cancers have an over-expression of HER2 resulting in increased cell growth and spread of cancer cells.

Tyrosine kinase inhibitors bind to the tyrosine kinase domain in the HER2 and stops activation of the signaling pathway. Monoclonal antibodies bind to the extracellular component of the HER2, prevent the actual substrates from binding to the receptors and stop the receptor activation.

HER2 inhibitors are used in the treatment of breast cancer.

List of HER2 inhibitors

View by  Generic | Brand
Drug Name Avg. Rating Reviews
neratinib systemic (Pro)
Brand name: Nerlynx
5.6
27 reviews
fam-trastuzumab deruxtecan systemic (Pro)
Brand name: Enhertu
7.9
27 reviews
trastuzumab systemic (Pro)
Brand names: Herceptin, Hercessi, Herzuma, Kanjinti, Ogivri, Ontruzant, Trazimera
8.9
12 reviews
hyaluronidase / trastuzumab systemic
Brand name: Herceptin Hylecta
10
1 review
zanidatamab systemic (Pro)
Brand name: Ziihera
No reviews
tucatinib systemic (Pro)
Brand name: Tukysa
No reviews
pertuzumab systemic (Pro)
Brand name: Perjeta
No reviews
margetuximab systemic (Pro)
Brand name: Margenza
No reviews
lapatinib systemic (Pro)
Brand name: Tykerb
No reviews
hyaluronidase / pertuzumab / trastuzumab systemic (Pro)
Brand name: Phesgo
No reviews
dacomitinib systemic (Pro)
Brand name: Vizimpro
No reviews
ado-trastuzumab emtansine systemic (Pro)
Brand name: Kadcyla
No reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.