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Marezine Side Effects

Generic Name: cyclizine

Note: This document contains side effect information about cyclizine. Some of the dosage forms listed on this page may not apply to the brand name Marezine.

For the Consumer

Applies to cyclizine: oral tablet

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Feeling very tired or weak.
  • Not able to pass urine.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling sleepy.
  • Dry mouth.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

For Healthcare Professionals

Applies to cyclizine: oral tablet, oral tablet chewable

Nervous system

Nervous system side effects have included drowsiness and sedation in many patients. Motor skills may be impaired. Cyclizine (the active ingredient contained in Marezine) may also cause restlessness, excitation, nervousness, and insomnia.[Ref]

Lingual-facial-buccal dyskinesias and generalized chorea occurred in an elderly patient, most probably due to the anticholinergic activity of cyclizine.[Ref]


Cardiovascular side effects have included hypotension, tachycardia, and palpitations. Cardiovascular changes recorded after intravenous administration of cyclizine (the active ingredient contained in Marezine) have included increase in heart rate, decrease in cardiac output, and increases in right atrial, pulmonary arterial, pulmonary artery wedge, and systemic arterial pressures.[Ref]


Gastrointestinal side effects have been mild in nature. These have included nausea, dry mouth, and constipation.[Ref]


Ocular side effects have included blurred vision, diplopia, and dry eyes due to its anticholinergic effects.[Ref]


Genitourinary side effects have included urinary retention and dysuria.[Ref]


Hepatic side effects have included a case report of hepatitis in at least one child. This side effect was confirmed upon drug rechallenge.[Ref]


Hypersensitivity side effects have included fixed drug eruptions.[Ref]


1. Klawans HL, Moskovitz C "Cyclizine-induced chorea. Observations on the influence of cyclizine on dopamine-related movement disorders." J Neurol Sci 31 (1977): 237-44

2. "Product Information. Marezine (cyclizine)." Glaxo Wellcome, Research Triangle Park, NC.

3. Kew MC, Segel J, Zoutendyk A ""Hypersensitivity hepatitis" associated with administration of cyclizine." Br Med J 2 (1973): 307

4. Griffiths WA, Peachey RD "Fixed drug eruption due to cyclizine." Br J Dermatol 82 (1970): 616-7

Some side effects of Marezine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.