Skip to Content

Lupaneta Pack Side Effects

Generic Name: leuprolide / norethindrone

Note: This page contains information about the side effects of leuprolide / norethindrone. Some of the dosage forms included on this document may not apply to the brand name Lupaneta Pack.

In Summary

Common side effects of Lupaneta Pack include: depression and migraine. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to leuprolide / norethindrone: powder for suspension 1 month, powder for suspension 3 month, tablet

In addition to its needed effects, some unwanted effects may be caused by leuprolide / norethindrone. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking leuprolide / norethindrone, check with your doctor or nurse immediately:

More common:
  • Crying
  • depersonalization
  • dysphoria
  • euphoria
  • feeling of warmth
  • mental depression
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • swelling
Incidence not known:
  • Anxiety
  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • chest pain
  • confusion
  • convulsions
  • cough
  • dark urine
  • difficult, burning, or painful urination
  • difficulty speaking
  • difficulty swallowing
  • dizziness or lightheadedness
  • double vision
  • fainting
  • fast heartbeat
  • flu-like symptoms
  • frequent urge to urinate
  • headache
  • hives or welts
  • inability to move the arms, legs, or facial muscles
  • increased sensitivity of the skin to sunlight
  • itching
  • joint or muscle pain or stiffness
  • lower back or side pain
  • nausea and vomiting
  • numbness or tingling in the face, arms, or legs
  • pain in the groin or genitals
  • pain, redness, or swelling in the arm or leg
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • right upper quadrant tenderness
  • severe sunburn
  • sharp back pain just below the ribs
  • skin rash
  • slow or fast heartbeat
  • slow speech
  • sudden shortness of breath or trouble breathing
  • sweating
  • thoughts or attempts at killing oneself
  • tightness in the chest
  • trouble breathing
  • trouble sleeping
  • trouble thinking or walking
  • unusual tiredness or weakness
  • yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with leuprolide / norethindrone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Acid or sour stomach
  • being forgetful
  • belching
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • blemishes on the skin
  • bloated or full feeling
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • changes in appetite
  • decreased interest in sexual intercourse
  • diarrhea
  • difficulty having a bowel movement (stool)
  • excess air or gas in the stomach or intestines
  • feeling of constant movement of self or surroundings
  • hair loss or thinning of the hair
  • headache, severe and throbbing
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • pain or tenderness from the breasts
  • passing gas
  • pimples
  • sensation of spinning
  • stomach discomfort, upset, or pain
  • weight gain
Less common:
  • Absent missed or irregular menstrual periods
  • itching of the vagina or genital area
  • pain during sexual intercourse
  • stopping of menstrual bleeding
  • thick, white vaginal discharge with no odor or with a mild odor

For Healthcare Professionals

Applies to leuprolide / norethindrone: oral and injectable kit

General

The most common adverse reactions leading to discontinuation of therapy included hot flashes (4%), emotional lability (4%), depression (4%) and acne (2%).
The most common adverse reaction observed were hot flashes and headaches.[Ref]

Cardiovascular

Leuprolide-Norethindrone:
Very common (10% or more): Hot flashes/sweats (up to 87%)

Leuprolide:
Very common (10% or more): Hot flashes/sweats (98%)
Postmarketing reports: Hypotension, hypertension, serious venous and arterial thrombotic and thromboembolic events (deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, transient ischemic attack[Ref]

Dermatologic

Leuprolide-Norethindrone:
Very common (10% or more): Androgen-like effects (acne, alopecia) (up to 18%), skin/mucous membrane reaction (up to 11%)

Leuprolide:
Common (1% to 10%): Androgen-like effects (acne, alopecia) (4%), skin/mucous membrane reaction (4%)[Ref]

Gastrointestinal

Leuprolide-Norethindrone:
Very common (10% or more): Altered bowel function (constipation, diarrhea) (up to 15%), nausea/vomiting (up to 29%)
Common (1% to 10%): GI disturbances (dyspepsia, flatulence) (up to 7%), changes in appetite (6%)

Leuprolide:
Very common (10% or more): Nausea/vomiting (25%), altered bowel function (constipation, diarrhea) (14%)
Common (1% to 10%): Changes in appetite (4%)%), GI disturbances (dyspepsia, flatulence) (4%)[Ref]

Genitourinary

Leuprolide-Norethindrone:
Very common (10% or more): Vaginitis (up to 15%%), breast changes/pain/tenderness (up to 13%)
Common (1% to 10%): Menstrual disorders (5%)
Frequency not reported: Urinary tract infection

Leuprolide:
Very common (10% or more): Vaginitis (20%)
Common (1% to 10%): Breast changes/pain/tenderness (6%), menstrual disorders (2%)[Ref]

Hematologic

Leuprolide:
Postmarketing reports: Decreased white blood count[Ref]

Hepatic

Leuprolide:
Postmarketing reports: Serious liver injury
Leuprolide-Norethindrone:
Common (1% to 10%): Elevated SGPT (at least twice the upper limit) (2%), elevated GGT (1.5%)[Ref]

Hypersensitivity

Leuprolide-Norethindrone:
Postmarketing reports: Allergic reactions (anaphylactic, rash, urticaria, photosensitivity)[Ref]

Local

Leuprolide-Norethindrone:
Common (1% to 10%): Injection site reaction (up to 9%)

Leuprolide:
Common (1% to 10%): Injection site reaction (2%)
Postmarketing reports: Localized reactions including induration and abscess at the site of injection[Ref]

Metabolic

Leuprolide-Norethindrone:
Very common (10% or more): Weight gain (up to 13%)
Common (1% to 10%): Edema (up to 9%), elevated SGPT (at least twice the upper limit) (2%), elevated GGT (1.5%)
Frequency not reported: Increased total cholesterol (greater than 240 mg/dL), decreased HDL cholesterol (less than 40 mg/dL), increased LDL cholesterol (greater than 160 mg/dL), increased LDL/HDL ratio (greater than 4), increased triglycerides (greater than 200 mg/dL)

Leuprolide:
Common (1% to 10%): Weight gain (12%)[Ref]

Musculoskeletal

Leuprolide:
Postmarketing reports: Spinal fracture, tenosynovitis-like symptoms, symptoms consistent with fibromyalgia[Ref]

Nervous system

Leuprolide-Norethindrone:
Very common (10% or more): Headache/migraine (up to 51%), insomnia/sleep disorders (up to 15%), dizziness/vertigo (up to 11%)
Common (1% to 10%): Neuromuscular disorder (leg cramps, paresthesia) (up to 9%), decreased libido (up to 7%), memory disorder (up to 4%)

Leuprolide:
Very common (10% or more): Headache/migraine (65%), insomnia/sleep disorders (31%), dizziness/vertigo (16%), decreased libido (10%)
Common (1% to 10%): Memory disorder (6%), neuromuscular disorder (leg cramps, paresthesia) (2%)
Postmarketing reports: Pituitary apoplexy, convulsion, peripheral neuropathy, paralysis[Ref]

Other

Leuprolide-Norethindrone:
Very common (10% or more): Pain (up to 29%), asthenia (up to 18%)

Leuprolide:
Very common (10% or more): Pain (24%), asthenia (18%)

Psychiatric

Leuprolide-Norethindrone:
Very common (10% or more): Depression/emotional lability (up to 34%), nervousness/anxiety (up to 11%)

Leuprolide:
Very common (10% or more): Depression/emotional lability (31%)
Common (1% to 10%): Nervousness/anxiety (8%)
Postmarketing reports: Mood swings, suicidal ideation and attempt[Ref]

Renal

Leuprolide-Norethindrone:
Frequency not reported: Renal calculus[Ref]

Respiratory

Leuprolide:
Postmarketing reports: Symptoms consistent with an asthmatic process[Ref]

References

1. "Product Information. Lupaneta Pack (leuprolide-norethindrone)." Abbott Pharmaceutical, Abbott Park, IL.

Not all side effects for Lupaneta Pack may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide