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Leuprolide / Norethindrone Dosage

Medically reviewed by Last updated on Jan 10, 2019.

Applies to the following strengths: 3.75 mg-5 mg; 11.25 mg-5 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Endometriosis

Leuprolide: 3.75 mg IM once a month or 11.25 mg IM once every three months
Norethindrone: 5 mg once daily
Duration of therapy: Not to exceed six months

Comments: Leuprolide should be administered by a healthcare provider. If symptoms recur consider retreatment for up to another six months. Treatment beyond two six-month courses has not been studied and is not recommended. Due to different release characteristics, similar doses of leuprolide 1 month and 3 month depot formulations are not equivalent.

Renal Dose Adjustments

Leuprolide: Data not available
Norethindrone: Data not available

Liver Dose Adjustments

Leuprolide: Data not available

Norethindrone: Mild to moderate liver dysfunction: Data not available.
Norethindrone: Contraindicated in markedly impaired liver function or disease.


Consult WARNINGS section for dosing related precautions.


Data not available

Other Comments

Reconstitution/preparation techniques: The manufacturer's product information should be consulted.

Patient advice: Use a form of birth control that does not contain hormones (diaphragm with spermicide, condoms with spermicide, a copper IUD)

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.