Leuprolide / Norethindrone Dosage

Usual Adult Dose for Endometriosis

Leuprolide: 3.75 mg IM once a month or 11.25 mg IM once every three months
Norethindrone: 5 mg once daily
Duration of therapy: Not to exceed six months

Comments: Leuprolide should be administered by a healthcare provider. If symptoms recur consider retreatment for up to another six months. Treatment beyond two six-month courses has not been studied and is not recommended. Due to different release characteristics, similar doses of leuprolide 1 month and 3 month depot formulations are not equivalent.

Renal Dose Adjustments

Leuprolide: Data not available
Norethindrone: Data not available

Liver Dose Adjustments

Leuprolide: Data not available

Norethindrone: Mild to moderate liver dysfunction: Data not available.
Norethindrone: Contraindicated in markedly impaired liver function or disease.

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Data not available

Other Comments

Reconstitution/preparation techniques: The manufacturer's product information should be consulted.

Patient advice: Use a form of birth control that does not contain hormones (diaphragm with spermicide, condoms with spermicide, a copper IUD)