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Ludiomil Side Effects

Generic Name: maprotiline

Note: This page contains information about the side effects of maprotiline. Some of the dosage forms included on this document may not apply to the brand name Ludiomil.

For the Consumer

Applies to maprotiline: oral tablet

In addition to its needed effects, some unwanted effects may be caused by maprotiline (the active ingredient contained in Ludiomil). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking maprotiline, check with your doctor or nurse as soon as possible:

More common:
  • Skin rash, redness, swelling, or itching
Less common:
  • Constipation (severe)
  • nausea or vomiting
  • shakiness or trembling
  • seizures (convulsions)
  • unusual excitement
  • weight loss
  • Breast enlargement—in males and females
  • confusion (especially in the elderly)
  • difficulty in urinating
  • fainting
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • inappropriate secretion of milk—in females
  • irregular heartbeat (pounding, racing, skipping)
  • sore throat and fever
  • swelling of testicles
  • yellow eyes or skin
Symptoms of overdose:
  • Convulsions (seizures)
  • dizziness (severe)
  • drowsiness (severe)
  • fast or irregular heartbeat
  • fever
  • muscle stiffness or weakness (severe)
  • restlessness or agitation
  • trouble in breathing
  • vomiting

Severity: Minor

Some of the side effects that can occur with maprotiline may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Blurred vision
  • decreased sexual ability
  • dizziness or lightheadedness (especially in the elderly)
  • drowsiness
  • dryness of mouth
  • headache
  • increased or decreased sexual drive
  • tiredness or weakness
Less common:
  • Constipation (mild)
  • diarrhea
  • heartburn
  • increased appetite and weight gain
  • increased sensitivity of skin to sunlight
  • increased sweating
  • trouble in sleeping
  • weight loss

Side Effects: Post Treatment

After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

For Healthcare Professionals

Applies to maprotiline: oral tablet


Gastrointestinal side effects including dry mouth (22%), constipation (6%), and nausea (2%) have been reported. Vomiting, epigastric distress, diarrhea, bitter taste, abdominal cramps, increased salivation, and dysphagia have rarely been reported.[Ref]

Nervous system

Nervous system side effects including drowsiness (16%), dizziness (8%), and tremor (3%) have been reported. Numbness, tingling, motor hyperactivity, akathisia, seizures, EEG alterations, tinnitus, extrapyramidal symptoms, ataxia, and dysarthria have rarely been reported.[Ref]


Psychiatric side effects including nervousness (6%), anxiety (3%), insomnia (2%), and agitation (2%) have been reported. Confusion (especially in the elderly), hallucinations, disorientation, delusions, restlessness, nightmares, hypomania, mania, exacerbation of psychosis, decrease in memory, and feelings of unreality have rarely been reported.[Ref]


General side effects including weakness and fatigue (4%), headache (4%), and drug fever have been reported. Weight loss or gain has rarely been reported.[Ref]


Ocular side effects including blurred vision (4%) have been reported. Accommodation disturbances and mydriasis have rarely been reported.[Ref]


Cardiovascular side effects including hypertension, hypotension, tachycardia, edema, arrhythmia, heart block, palpitation, and syncope have rarely been reported.[Ref]


Genitourinary side effects including urinary retention and delayed micturition have been reported. Urinary frequency has rarely been reported.[Ref]


Dermatologic side effects including skin rash, petechiae, itching, alopecia, excessive perspiration, flushing, and photosensitization have rarely been reported.[Ref]


Endocrine side effects including increased or decreased libido, impotence, and elevation or depression of blood sugar levels have rarely been reported.[Ref]


Hepatic side effects including altered liver function and jaundice have rarely been reported.[Ref]


Respiratory side effects including several cases of interstitial pneumonitis have been reported. Nasal congestion has rarely been reported.[Ref]

In some of the cases, the interstitial pneumonitis was associated with eosinophilia and increased liver enzymes. However, no clear causal relationship to maprotiline has been established.[Ref]


1. "Product Information. Ludiomil (maprotiline)." Ciba-Geigy Pharmaceuticals, East Hanover, NJ.

Not all side effects for Ludiomil may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.