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Ludiomil Side Effects

Generic name: maprotiline

Medically reviewed by Last updated on Nov 2, 2023.

Note: This document contains side effect information about maprotiline. Some dosage forms listed on this page may not apply to the brand name Ludiomil.

Applies to maprotiline: oral tablet.


Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to maprotiline: oral tablet.


The most commonly reported side effects include dry mouth, drowsiness, and dizziness.[Ref]


Very common (10% or more): Dry mouth (up to 22%)

Common (1% to 10%): Constipation, nausea

Rare (0.01% to 0.1%): Vomiting, epigastric distress, diarrhea, bitter taste, abdominal cramps, dysphagia, increased salivation

Frequency not reported: Sublingual adenitis, black tongue, stomatitis, paralytic ileus[Ref]

Nervous system

Very common (10% or more): Drowsiness (up to 16%)

Common (1% to 10%): Dizziness, tremor, headache

Rare (0.01% to 0.1%): Decreased memory, numbness, tingling, motor hyperactivity, akathisia, EEG alterations, extrapyramidal symptoms, ataxia, dysarthria

Frequency not reported: Stroke, peripheral neuropathy[Ref]


Common (1% to 10%): Nervousness, anxiety, insomnia, agitation

Rare (0.01% to 0.1%): Confusional states, hallucinations, disorientation, delusions, restlessness, nightmares, hypomania, mania, psychosis exacerbation, feelings of unreality, decreased libido[Ref]


Common (1% to 10%): Weakness, fatigue

Rare (0.01% to 0.1%): Tinnitus, drug fever[Ref]


Common (1% to 10%): Blurred vision

Rare (0.01% to 0.1%): Accommodation disorder, mydriasis[Ref]


Rare (0.01% to 0.1%): Hypotension, hypertension, tachycardia, palpitation, arrhythmia, heart block, syncope, edema

Frequency not reported: Myocardial infarction[Ref]


Rare (0.01% to 0.1%): Skin rash, petechia, itching, photosensitization, excessive perspiration, flushing, alopecia

Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]


Rare (0.01% to 0.1%): Urinary retention, delayed micturition, impotence, urinary frequency

Frequency not reported: Breast enlargement (in women), galactorrhea, testicular swelling[Ref]


Rare (0.01% to 0.1%): Altered liver function, jaundice

Postmarketing reports: Increased liver enzymes[Ref]


Rare (0.01% to 0.1%): Elevation/depression of blood sugar levels, weight loss or gain[Ref]


Rare (0.01% to 0.1%): Nasal congestion

Postmarketing reports: Interstitial pneumonitis[Ref]

Interstitial pneumonitis was occasionally associated with eosinophilia and increased liver enzymes. However, no clear causal relationship to treatment has been established.[Ref]


Frequency not reported: Bone marrow depression, agranulocytosis, eosinophilia, purpura, thrombocytopenia[Ref]


Frequency not reported: Gynecomastia (in men)[Ref]


1. (2001) "Product Information. Ludiomil (maprotiline)." Ciba-Geigy Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.