Skip to main content

Maprotiline Pregnancy and Breastfeeding Warnings

Brand names: Ludiomil

Maprotiline Pregnancy Warnings

Animal studies have failed to reveal evidence of impaired fertility or fetal harm. There are no controlled data in human pregnancy.

To monitor the outcomes of pregnant women exposed to this drug, a pregnancy registry has been established. Physicians are encouraged to register patients and pregnant women are encouraged to register themselves by going to

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

This drug should be used during pregnancy only if clearly needed.

US FDA pregnancy category: B

Comment: A pregnancy registry is available.

See references

Maprotiline Breastfeeding Warnings

After a single dose of 100 mg orally, peak milk levels of 110 mcg/L occurred at approximately 8 hours. Patients at steady state had milk levels corresponding to blood levels.

Caution is recommended.

Excreted into human milk: Yes

Comment: Use of preferred antidepressants should be considered, especially when breastfeeding newborn or premature infants.

See references

References for pregnancy information

  1. Product Information. Ludiomil (maprotiline). Ciba-Geigy Pharmaceuticals. 2001;PROD.

References for breastfeeding information

  1. Product Information. Ludiomil (maprotiline). Ciba-Geigy Pharmaceuticals. 2001;PROD.
  2. United States National Library of Medicine. Toxnet. Toxicology Data Network. 2013.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.