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Isosorbide mononitrate Side Effects

Medically reviewed by Last updated on Jul 20, 2023.

Applies to isosorbide mononitrate: oral tablet, oral tablet extended release.

Serious side effects

Along with its needed effects, isosorbide mononitrate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking isosorbide mononitrate:

Less common


Get emergency help immediately if any of the following symptoms of overdose occur while taking isosorbide mononitrate:

Symptoms of overdose

Other side effects

Some side effects of isosorbide mononitrate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to isosorbide mononitrate: oral tablet, oral tablet extended release.


The most common adverse effects are headache and dizziness.[Ref]

Nervous system

Very common (10% or more): Headache (up to 57%), dizziness (up to 11%)

Common (1% to 10%): Light-headedness

Frequency not reported: Bitter taste, paresthesia, impaired concentration, tremor, hypoesthesia, migraine, neuritis, paresis, somnolence, fainting, drowsiness

Postmarketing reports: Syncope[Ref]


Common (1% to 10%): Cardiovascular disorder, flushing, hypotension

Frequency not reported: Acute myocardial infarction, apoplexy, arrhythmias, bradycardia, edema, hypertension, pallor, palpitations, tachycardia, hot flushes, cardiac failure, arrhythmia, arrhythmia atrial, atrial fibrillation, bundle branch block, extrasystole, ventricular tachycardia, angina pectoris aggravated, heart murmur, heart sound abnormal, myocardial infarction, Q wave abnormality, intermittent claudication, varicose vein, reflex tachycardia, collapse, bradyarrhythmia, paroxysmal bradycardia, orthostatic hypotension[Ref]


Common (1% to 10%): Nausea, abdominal pain, diarrhea, gastrointestinal disturbances

Frequency not reported: Dry mouth, dyspepsia, vomiting, constipation, flatulence, gastric ulcer, gastritis, glossitis, hemorrhagic gastric ulcer, hemorrhoids, loose stools, melena, heartburn[Ref]


Common (1% to 10%): Allergic reaction[Ref]


Frequency not reported: Methemoglobinemia, thrombocytopenia, hypochromic anemia[Ref]


Common (1% to 10%): Fatigue, pain, chest pain, tiredness

Frequency not reported: Susurrus aurium, vertigo, asthenia, fever, flu-like symptoms, malaise, rigors, earache, tinnitus, tympanic membrane perforation, breast pain, feeling of weakness[Ref]


Common (1% to 10%): Upper respiratory infection, increased cough

Frequency not reported: Asthma, dyspnea, sinusitis, bronchitis, bronchospasm, coughing, increased sputum, nasal congestion, pharyngitis, pneumonia, pulmonary infiltration, rales, rhinitis, hypoxia[Ref]


Common (1% to 10%): Rash, pruritus

Frequency not reported: Sweating, purpura, acne, hair texture abnormal, increased sweating, skin nodule, leg ulcer, exfoliative dermatitis, excessive perspiration, allergic dermatitis, hyperhidrosis[Ref]


Common (1% to 10%): Emotional lability, sleep disturbances

Frequency not reported: Anxiety, depression, insomnia, nervousness, nightmares, restlessness, confusion, decreased libido, paroniria[Ref]


Very rare (less than 0.01%): Myalgia

Frequency not reported: Back pain, muscle cramps, neck pain, arthralgia, frozen shoulder, muscle weakness, musculoskeletal pain, myositis, tendon disorder, torticollis[Ref]


Frequency not reported: Anorexia, thirst, decreased weight, hyperuricemia, hypokalemia, poor appetite[Ref]


Frequency not reported: Prostatic disorder, impotence, atrophic vaginitis, polyuria, urinary tract infection[Ref]


Frequency not reported: Amblyopia, ptosis, conjunctivitis, photophobia, vision abnormal[Ref]


Frequency not reported: Bacterial infection, moniliasis, viral infection[Ref]


Frequency not reported: Serum glutamic oxaloacetic transaminase (SGOT) increased, serum glutamate-pyruvate transaminase (SGPT) increased[Ref]


Frequency not reported: Pituitary hemorrhage[Ref]


Frequency not reported: Renal calculus[Ref]


1. Product Information. ISMO (isosorbide mononitrate). Wyeth-Ayerst Laboratories. 2002;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.