Isosorbide Mononitrate Dosage

Medically reviewed by Drugs.com. Last updated on March 1, 2021.

Applies to the following strengths: 20 mg; 120 mg; 30 mg; 60 mg; 10 mg

Usual Adult Dose for:

Angina Pectoris Prophylaxis
Angina Pectoris

Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Precautions
Dialysis

Usual Adult Dose for Angina Pectoris Prophylaxis

IMMEDIATE RELEASE:
20 mg orally twice a day, 7 hours apart

Comments:
-Consider 5 mg twice daily for small statured patients; increase to at least 10 mg twice daily in first 2 to 3 days.
-Asymmetric dosing (7 hours apart) provides a nitrate-free interval to minimize tolerance.
-Start at the low end of the dosing range for elderly patients.
-Doses above 20 mg twice daily have not been adequately studied; 5 mg twice daily is clearly effective for only the first day.

Use: Prevention and treatment of angina pectoris due to coronary artery disease; onset of action is not sufficiently rapid to be useful in aborting an acute anginal episode.

EXTENDED RELEASE:
30 to 60 mg orally once a day in the morning

Maximum dose: 240 mg orally once a day in the morning

Comments:
-Swallow whole (do not crush or chew) with half-glass of fluid.
-Start at low end of dosing range for elderly patients.

Use: Prevention of angina pectoris due to coronary artery disease; onset of action is not sufficiently rapid to be useful in aborting an acute anginal episode.