Skip to Content

IncobotulinumtoxinA Side Effects

For the Consumer

Applies to incobotulinumtoxinA: intramuscular powder for solution

Along with its needed effects, incobotulinumtoxinA may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking incobotulinumtoxinA:

More common—for cervical dystonia

  • Difficulty with swallowing
  • muscle or bone pain
  • muscle weakness
  • pain in the neck

More common—for blepharospasm

  • Dry eyes

Rare—for glabellar lines

  • Itching, pain, redness, or swelling at the injection site
  • pain in the face
  • swelling of the eyelids

Incidence Not Known

  • Changes in patterns and rhythms of speech
  • fast heartbeat
  • fever
  • hives, itching, or rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • muscle spasm
  • pain at the injection site
  • redness of the skin
  • slurred speech
  • swelling of the eyes or eyelids
  • swelling of the face, lips, hands, or feet
  • tightness in the chest
  • trouble with speaking
  • troubled breathing or swallowing

Some side effects of incobotulinumtoxinA may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common—for cervical dystonia

  • Chills
  • cough
  • lower back or side pain
  • painful or difficult urination

More common—for blepharospasm

Less common—for blepharospasm

  • Difficult or labored breathing
  • muscle aches
  • sneezing
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness

Less common—for upper limb spasticity

  • Dry mouth
  • fever
  • headache
  • muscle aches
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness

Rare—for glabellar lines

  • Drooping of the eyelids
  • increased blinking
  • twitching of the eyelids

Incidence Not Known

  • Difficulty with moving
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • nausea
  • painful blisters on the trunk of the body
  • swollen joints

For Healthcare Professionals

Applies to incobotulinumtoxinA: intramuscular powder for injection

Musculoskeletal

Very common (10% or more): Neck pain (up to 16%), muscular weakness (up to 14%)

Common (1% to 10%): Musculoskeletal pain, muscle spasms, musculoskeletal stiffness

Uncommon (0.1% to 1%): Pain in extremity[Ref]

Gastrointestinal

Very common (10% or more): Dysphagia (up to 18%), dry mouth (16%)

Common (1% to 10%): Diarrhea, nausea, oropharyngeal pain, lip disorder, viral gastroenteritis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, epilepsy

Uncommon (0.1% to 1%): Speech disorder, dysesthesia[Ref]

Local

Common (1% to 10%): Injection site pain, injection site hematoma

Very rare (less than 0.01%): Spread of toxin

Frequency not reported: Injection site reaction, allergic dermatitis, localized allergic reactions (e.g., welling, edema, erythema, pruritus, rash), herpes zoster[Ref]

Ocular

Common (1% to 10%): Dry eye (19%), eyelid ptosis (19%)

Uncommon (0.1% to 1%): Impaired vision, blurred vision, lacrimation increased, eye swelling, eyelid edema, diplopia[Ref]

Respiratory

Common (1% to 10%): Asthma, nasopharyngitis, respiratory tract infection, dyspnea, bronchitis[Ref]

Immunologic

Common (1% to 10%): Sinusitis, nasopharyngitis, respiratory tract infection, viral gastroenteritis, tooth infection

Postmarketing reports: Flu-like symptoms[Ref]

Cardiovascular

Common (1% to 10%): Hypertension[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Metabolic

Common (1% to 10%): Hypercholesterolemia, hyperglycemia[Ref]

Other

Common (1% to 10%): Asthenia

Uncommon (0.1% to 1%): Dysphonia, facial paresis, feeling hot

Rare (less than 0.1%): Tenderness[Ref]

References

1. "Product Information. Xeomin (botulinum toxin type A (obsolete) (botulinum toxin type A))." Merz Pharmaceuticals, Greensboro, NC.

2. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Hide