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Hyperstat IV Side Effects

Generic Name: diazoxide

Note: This page contains information about the side effects of diazoxide. Some of the dosage forms included on this document may not apply to the brand name Hyperstat IV.

For the Consumer

Applies to diazoxide: oral capsule, oral suspension

In addition to its needed effects, some unwanted effects may be caused by diazoxide (the active ingredient contained in Hyperstat IV). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking diazoxide:

Rare
  • Chest pain
Incidence not known:
  • Abdominal or stomach pain
  • black, tarry stools
  • blood in the urine
  • bloody nose
  • blurred vision
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • extreme thirst
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • heavier menstrual periods
  • increased hunger
  • increased thirst
  • increased urination
  • loss of consciousness
  • nausea
  • pinpoint red spots on the skin
  • seizures
  • skin rash
  • stomachache
  • sweating
  • troubled breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • urinating large amounts or urinating very little
  • vomiting
  • weakness

Minor Side Effects

Some of the side effects that can occur with diazoxide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Increased hair growth, especially on the forehead, back, arms, and legs
Incidence not known:
  • Loss of appetite
  • loss of taste
  • weight loss

For Healthcare Professionals

Applies to diazoxide: compounding powder, injectable solution, oral capsule, oral suspension

General

The most common reactions reported following diazoxide (the active ingredient contained in Hyperstat IV) administration include hypotension (7%), nausea and vomiting (4%), dizziness and weakness (2%).[Ref]

Cardiovascular

Cardiovascular effects including sodium and water retention following repeated injections, hypotension, shock, myocardial ischemia, myocardial and cerebral infarction, angina, atrial and ventricular arrhythmias, marked electrocardiographic changes, optic nerve infarction, supraventricular tachycardia and palpitation, bradycardia, and chest discomfort have been reported.[Ref]

Angina with myocardial and cerebral infarction have been associated with the use of a 300 mg intravenous dose of diazoxide.

One case of optic nerve infarction was reported following a single 300 mg bolus dose of diazoxide, as a result of a sudden reduction in diastolic pressure.

Results from one prospective trial conducted in patients with severe hypertension and coronary artery disease showed a 50% incidence of ischemic changes in the electrocardiogram following single 300 mg bolus injections of diazoxide.[Ref]

Nervous system

Nervous system affects reported following diazoxide (the active ingredient contained in Hyperstat IV) administration include cerebral ischemia, convulsions, paralysis, confusion, numbness of the hands, orthostatic hypotension, sweating, flushing, generalized or localized sensations of warmth, headache, dizziness, lightheadedness, sleepiness, lethargy, somnolence, drowsiness, euphoria, tinnitus, momentary loss of hearing, weakness and anxiety.[Ref]

Gastrointestinal

Gastrointestinal side effects have been rarely reported and include acute pancreatitis, nausea, vomiting, abdominal discomfort, anorexia, alteration in taste, parotid swelling, salivation, dry mouth, lacrimation, ileus, constipation and diarrhea.[Ref]

Metabolic

Metabolic effects including hyperglycemia have been reported in diabetic and nondiabetic patients, especially after repeated injections. Transient retention of nitrogenous wastes has also been reported.[Ref]

Respiratory

Respiratory effects including dyspnea, cough and choking sensation have been reported.[Ref]

Hypersensitivity

Hypersensitivity reactions characterized by rash, leukopenia, fever and papilledema induced by plasma volume expansion secondary to the administration of diazoxide (the active ingredient contained in Hyperstat IV) have been reported.[Ref]

Other

Other effects including warmth or pain along the injected vein, cellulitis and/or phlebitis at the injection site of extravasation, back pain, increased nocturia, malaise, blurred vision, hirsutism, and decreased libido have been reported.[Ref]

References

1. "Product Information. Hyperstat I.V. (diazoxide)." Schering Corp, Kenilworth, NJ.

Not all side effects for Hyperstat IV may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about Hyperstat IV (diazoxide)

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