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Clevidipine

Generic Name: clevidipine (kle VID a peen)
Brand Name: Cleviprex

Medically reviewed by Drugs.com on Mar 14, 2019 – Written by Cerner Multum

What is clevidipine?

Clevidipine is a calcium channel blocker that is used to treat high blood pressure (hypertension) in people who cannot take medicine by mouth.

Clevidipine may also be used for purposes not listed in this medication guide.

Important Information

If possible before you receive clevidipine, tell your doctor if you have high cholesterol or triglycerides (especially if you also have pancreatitis), aortic stenosis (narrowing of aortic valves in the heart), lipoid nephrosis (a kidney disorder), or if you are allergic to eggs or soy products.

In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received clevidipine.

Before taking this medicine

You should not be treated with clevidipine if you are allergic to it, or if you have:

  • high cholesterol or triglycerides (especially if you also have pancreatitis);

  • problems with metabolizing fats;

  • severe narrowing of the aortic valve in your heart (aortic stenosis);

  • a kidney disorder called lipoid nephrosis; or

  • an allergy to eggs, soybeans, or soy products.

If possible before you receive clevidipine, tell your caregivers if you have ever had:

In an emergency, you may not be able to tell caregivers if you are pregnant or breastfeeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.

How is clevidipine given?

Clevidipine is given as an infusion into a vein. A healthcare provider will give you this injection.

Your blood pressure and other vital signs will be watched closely. Your dose will be adjusted as your blood pressure normalizes.

You may be given another blood pressure medication to take after treatment with clevidipine.

If your doctor does not prescribe blood pressure medication for you to keep taking, you will need to be watched for at least 8 hours after your last clevidipine injection to make sure your blood pressure does not go back up again.

Keep using your blood pressure medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

You may need to follow a special diet to reduce your intake of fats. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.

What happens if I miss a dose?

Because you will receive clevidipine in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since clevidipine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving clevidipine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Clevidipine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • chest pain;

  • pounding heartbeats or fluttering in your chest;

  • a light-headed feeling, like you might pass out;

  • severe dizziness or confusion;

  • vision problems;

  • shortness of breath; or

  • swelling in your hands or feet.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Clevidipine dosing information

Usual Adult Dose for Hypertension:

Initial dose: 1 to 2 mg/hour IV infusion

Dose titration: Dose may be doubled at short (90 second) intervals initially. As blood pressure approaches goal, dose increases should be less than doubling and intervals between dose adjustments should increase to every 5 to 10 minutes. An increase of approximately 1 to 2 mg/hour generally produces an additional 2 to 4 mmHg decrease in systolic pressure.

Maintenance dose: The desired therapeutic response for most patients occurs at doses of 4 to 6 mg/hour. Patients with severe hypertension may require doses up to 32 mg/hour.

Maximum dose: Most patients were treated with maximum doses of 16 mg/hour or less; however, there is limited short-term experience with doses up to 32 mg/hour. Due to lipid load restrictions, no more than 1000 mL (or an average of 21 mg/hour) is recommended per 24-hour period.

Duration of therapy: There is little experience with infusion durations beyond 72 hours at any dose.

Transition to an oral antihypertensive agent: Discontinue this drug or titrate downward while appropriate oral treatment is established.

Use: Reduction of blood pressure when oral treatment is not feasible or not desirable.

What other drugs will affect clevidipine?

If you have been using a beta-blocker medication (such as atenolol, carvedilol, metoprolol, nebivolol, propranolol, sotalol, and others), you should not stop using it suddenly. Follow your doctor's instructions about tapering your dose. Stopping a beta-blocker too quickly can cause serious heart problems that will not be prevented by clevidipine.

Other drugs may affect clevidipine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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