Skip to Content

Clevidipine Side Effects

For the Consumer

Applies to clevidipine: intravenous emulsion

Along with its needed effects, clevidipine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking clevidipine:

More common
  • Agitation
  • confusion
  • decreased urine output
  • depression
  • dizziness
  • fainting
  • fast or irregular heartbeat
  • headache
  • hostility
  • irritability
  • lethargy
  • loss of consciousness
  • muscle twitching
  • nausea
  • rapid weight gain
  • seizures (convulsions)
  • stupor
  • swelling of the face, ankles, or hands
  • unusual tiredness or weakness
  • Chest pain or discomfort
  • difficult or labored breathing
  • pain or discomfort in the arms, jaw, back, or neck
  • shortness of breath
  • stopping of the heart
  • sweating
  • tightness in the chest
  • unconsciousness
  • very low blood pressure or pulse
  • vomiting
  • wheezing

For Healthcare Professionals

Applies to clevidipine: intravenous emulsion


Cardiovascular side effects have included atrial fibrillation (up to 21%), myocardial infarction (less than 1%), cardiac arrest (less than 1%), systemic hypotension, and reflex tachycardia. Hypotension and reflex tachycardia have been reported during postmarketing experience.[Ref]


Gastrointestinal side effects have included nausea (up to 21%) and vomiting (3.2%). Ileus and nausea have been reported during postmarketing experience.[Ref]


Renal side effects have included acute renal failure (up to 9%).[Ref]

Nervous system

Nervous system side effects have included headache (6.3%) and syncope (less than 1%).[Ref]


Respiratory side effects have included dyspnea (less than 1%).[Ref]


Other side effects have included decreased oxygen saturation (possible pulmonary shunting) during postmarketing experience.


Metabolic side effects have included increased blood triglycerides during postmarketing experience.


Hypersensitivity side effects have included hypersensitivity during postmarketing experience.


1. "Clevidipine (Cleviprex) for IV treatment of severe hypertension." Med Lett Drugs Ther 50 (2008): 73-4

2. "Product Information. Cleviprex (clevidipine)." The Medicines Company, Parsippany, NJ.

Some side effects of clevidipine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.