Clevidipine Side Effects
Medically reviewed by Drugs.com. Last updated on May 12, 2025.
Applies to clevidipine: intravenous emulsion.
Precautions
Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to another medicine that works the same way. If you have any concerns about this, talk to your doctor.
Serious side effects of clevidipine
Along with its needed effects, clevidipine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking clevidipine:
More common side effects
- agitation
- confusion
- decreased urine output
- depression
- dizziness
- fainting
- fast or irregular heartbeat
- headache
- hostility
- irritability
- lethargy
- loss of consciousness
- muscle twitching
- nausea
- rapid weight gain
- seizures (convulsions)
- stupor
- swelling of the face, ankles, or hands
- unusual tiredness or weakness
Rare side effects
- chest pain or discomfort
- difficult or labored breathing
- pain or discomfort in the arms, jaw, back, or neck
- shortness of breath
- stopping of the heart
- sweating
- tightness in the chest
- unconsciousness
- very low blood pressure or pulse
- vomiting
- wheezing
See also:
For healthcare professionals
Applies to clevidipine: intravenous emulsion.
General adverse events
Atrial fibrillation, sinus tachycardia, and hypotension were frequently observed in the perioperative population.[Ref]
Cardiovascular
- Very common (10% or more): Atrial fibrillation (up to 32.9%), sinus tachycardia (up to 30.5%), hypotension (up to 15.1%)
- Common (1% to 10%): Flushing
- Uncommon (0.1% to 1%): Atrial flutter, tachycardia, congestive heart failure, bradycardia, complete atrioventricular block, bundle branch block
- Frequency not reported: Myocardial infarction, cardiac arrest
- Postmarketing reports: Reflex tachycardia[Ref]
Gastrointestinal
- Very common (10% or more): Nausea (up to 21%)
- Common (1% to 10%): Vomiting
- Uncommon (0.1% to 1%): Constipation
- Rare (less than 0.1%): Ileus[Ref]
Nervous system
Other
- Common (1% to 10%): Edema, chest pain, feeling hot[Ref]
Metabolic
- Common (1% to 10%): Oxygen saturation decreased
- Postmarketing reports: Blood triglycerides increased[Ref]
Renal
- Common (1% to 10%): Acute renal failure[Ref]
Genitourinary
- Common (1% to 10%): Polyuria[Ref]
Respiratory
Immunologic
- Uncommon (0.1% to 1%): Hypersensitivity[Ref]
References
1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
2. (2008) "Product Information. Cleviprex (clevidipine)." The Medicines Company
More about clevidipine
- Check interactions
- Compare alternatives
- Dosage information
- During pregnancy
- Drug class: calcium channel blockers
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Further information
Clevidipine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.