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Diazoxide Dosage

Medically reviewed by Drugs.com. Last updated on Nov 23, 2020.

Applies to the following strengths: 15 mg/mL; 50 mg/mL; 50 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypoglycemia

Initial dose: 3 mg/kg per day divided into three equal doses every 8 hours
Usual dose: 3 to 8 mg/kg orally, divided into two or three equal doses every 8 or 12 hours

Comments:
-Use only after confirmed diagnosis of hypoglycemia due to one of the listed conditions.
-Use only if specific medical therapy or surgical management has been unsuccessful or is not feasible.
-Observe patients closely during treatment initiation.
-Carefully monitor clinical response and blood glucose until the patient has stabilized, usually several days.
-Discontinue if no efficacy after two to three weeks use.
-Individualize dose based on clinical and laboratory effects with the least amount of drug.

Use: Hypoglycemia due to hyperinsulinism associated with inoperable islet cell adenoma or carcinoma, or extrapancreatic malignancy

Usual Pediatric Dose for Hypoglycemia

Infants and newborns:
Initial dose: 10 mg/kg/day divided into three equal doses every 8 hours
Usual dose: 8 to 15 mg/kg/day divided into two or three equal doses every 8 or 12 hours

Children:
Initial dose: 3 mg/kg per day divided into three equal doses every 8 hours
Usual dose: 3 to 8 mg/kg orally, divided into two or three equal doses every 8 or 12 hours

Comments:
-Use only after confirmed diagnosis of hypoglycemia due to one of the listed conditions.
-Use only if specific medical therapy or surgical management has been unsuccessful or is not feasible.
-Observe patients closely during treatment initiation.
-Carefully monitor clinical response and blood glucose until the patient has stabilized, usually several days.
-Discontinue if no efficacy after two to three weeks use.
-Individualize dose based on clinical and laboratory effects with the least amount of drug.
-Use special care to assure accurate dosing in infants and young children.

Uses:
-Hypoglycemia due to hyperinsulinism associated with leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, or adenomatosis
-May be used preoperatively as a temporary measure, or postoperatively if hypoglycemia persists

Renal Dose Adjustments

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution is recommended.

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Use for functional hypoglycemia
-Hypersensitivity to diazoxide or other thiazides, unless benefits outweigh risks

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.