Skip to main content

Hydrochlorothiazide / telmisartan Side Effects

Medically reviewed by Last updated on Nov 16, 2022.


More frequently reported side effects include: dizziness. Continue reading for a comprehensive list of adverse effects.

Applies to hydrochlorothiazide / telmisartan: oral tablet.


Oral route (Tablet)

Drugs with direct action on the renin-angiotensin system can cause injury or death to the developing fetus when used during pregnancy. Stop therapy as soon as possible if pregnancy occurs.

Serious side effects

Along with its needed effects, hydrochlorothiazide/telmisartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / telmisartan:

Less common

  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • confusion
  • decreased urine
  • difficult, burning, or painful urination
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • dry mouth
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • frequent urge to urinate
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • seizures
  • sudden sweating
  • trouble breathing
  • unusual tiredness or weakness


  • Chills
  • cold sweats


  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Incidence not known

  • Persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shiny bump
  • white, yellow or waxy scar-like area

Other side effects

Some side effects of hydrochlorothiazide / telmisartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • cough
  • difficulty breathing
  • dizziness
  • ear congestion
  • fever
  • headache
  • loss of voice
  • runny or stuffy nose
  • sneezing
  • sore throat

Less common

  • Acid or sour stomach
  • back pain
  • belching
  • blistering, peeling, loosening of the skin
  • cough producing mucus
  • diarrhea
  • heartburn
  • hoarseness
  • indigestion
  • itching
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • pain or tenderness around the eyes and cheekbones
  • rash
  • red irritated eyes
  • red skin lesions, often with a purple center
  • shivering
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach pain
  • sweating
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble sleeping
  • trouble swallowing
  • voice changes

Incidence not known

  • Decreased interest in sexual intercourse
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance

For Healthcare Professionals

Applies to hydrochlorothiazide / telmisartan: oral tablet.


The most common adverse effect was upper respiratory tract infection.[Ref]


Common (1% to 10%): Sinusitis, upper respiratory tract infection, cough

Uncommon (0.1% to 1%): Dyspnea

Rare (less than 0.1%): Bronchitis, pharyngitis, respiratory distress, pneumonitis, pulmonary edema


Very common (10% or more): Upper respiratory tract infection (10%)

Common (1% to 10%): Sinusitis

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema


Common (1% to 10%): Sinusitis, upper respiratory tract infection

Uncommon (0.1% to 1%): Cough

Frequency not reported: Asthma, rhinitis, dyspnea, epistaxis

Postmarketing reports: Interstitial lung disease[Ref]


Common (1% to 10%): Fatigue, influenza-like symptoms, pain

Uncommon (0.1% to 1%): Chest pain


Common (1% to 10%): Fatigue, influenza-like symptoms

Frequency not reported: Weakness, pyrexia


Common (1% to 10%): Fatigue, influenza-like symptoms

Uncommon (0.1% to 1%): Asthenia

Frequency not reported: Earache, fever, malaise, leg edema, peripheral edema, dependent edema, chest pain

Postmarketing reports: Weakness, edema, face edema, pain[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Syncope, paresthesia, vertigo


Common (1% to 10%): Dizziness

Frequency not reported: Lightheadedness


Common (1% to 10%): Dizziness

Rare (less than 0.1%): Somnolence

Frequency not reported: Tinnitus, migraine, hypoesthesia, cerebrovascular disorder, vertigo, paresthesia, hypoesthesia, involuntary muscle contraction

Postmarketing reports: Headache, syncope[Ref]


Common (1% to 10%): Diarrhea, nausea

Uncommon (0.1% to 1%): Dry mouth, flatulence

Rare (less than 0.1%): Abdominal pain, constipation, dyspepsia, vomiting, gastritis


Common (1% to 10%): Diarrhea, nausea

Frequency not reported: Sialadenitis, pancreatitis, stomach discomfort, cramping, gastric irritation


Common (1% to 10%): Diarrhea, nausea

Rare (less than 0.1%): Stomach discomfort

Frequency not reported: Hemorrhoids, gastroenteritis, enteritis, gastroesophageal reflux, toothache, non-specific gastrointestinal disorder, flatulence, constipation, gastritis, dry mouth,

Postmarketing reports: Dyspepsia, abdominal pain[Ref]


Common (1% to 10%): BUN increased 11.2 mg/dL or greater, serum creatinine increased 0.5 mg/dL or greater


Frequency not reported: Nephritis interstitial, renal dysfunction, renal failure


Uncommon (0.1% to 1%): Renal impairment, acute renal failure[Ref]


Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Erectile dysfunction

Frequency not reported: Impotence


Frequency not reported: Glycosuria


Uncommon (0.1% to 1%): Urinary tract infection

Frequency not reported: Micturition frequency, cystitis, impotence

Postmarketing reports: Erectile dysfunction[Ref]


Common (1% to 10%): Hemoglobin decreased 2 g/dL or greater

Uncommon (0.1% to 1%): Hematocrit decreased 9% or more


Frequency not reported: Aplastic anemia, hemolytic anemia, bone marrow depression, leukopenia, neutropenia, agranulocytosis, thrombocytopenia


Uncommon (0.1% to 1%): Anemia

Rare (less than 0.1%): Eosinophilia, thrombocytopenia, hemoglobin decreased[Ref]


Uncommon (0.1% to 1%): Tachycardia, arrhythmias, hypotension, orthostatic hypotension


Frequency not reported: Vasculitis necrotizing


Uncommon (0.1% to 1%): Bradycardia

Frequency not reported: Palpitation, angina pectoris, abnormal ECG, flushing, hypertension

Postmarketing reports: Atrial fibrillation, congestive heart failure, myocardial infarction, blood pressure increased, hypertension aggravated, hypotension, postural hypotension[Ref]


Uncommon (0.1% to 1%): Back pain, muscle spasm, myalgia

Rare (less than 0.1%): Arthralgia, muscle cramp, pain in limb, blood creatine phosphokinase increased

Frequency not reported: Leg pain, cramps in legs

Postmarketing reports: Exacerbation or activation of systemic lupus erythematosus


Frequency not reported: Lupus-like syndrome, muscle spasm


Rare (less than 0.1%): Arthrosis, tendon pain, tendonitis, tenosynovitis

Frequency not reported: Arthritis, arthralgia, leg pain, leg cramps, myalgia

Postmarketing reports: Back pain, muscle cramps, creatine phosphokinase increased, rhabdomyolysis[Ref]


Uncommon (0.1% to 1%): Hypokalemia, blood uric acid increased

Rare (less than 0.1%): Hyperuricemia, hyponatremia


Frequency not reported: Diabetes mellitus inadequate control, anorexia, appetite decreased, electrolyte imbalance, hypercholesterolemia, hyperglycemia, hypovolemia, triglycerides increased, hyperuricemia


Uncommon (0.1% to 1%): Hyperkalemia

Rare (less than 0.1%): Hypoglycemia in diabetic patients

Frequency not reported: Diabetes mellitus, gout, hypercholesterolemia

Postmarketing reports: Uric acid increased[Ref]


Uncommon (0.1% to 1%): Anxiety

Rare (less than 0.1%): Depression, insomnia, sleep disorder


Frequency not reported: Restlessness


Frequency not reported: Nervousness, insomnia, anxiety, depression[Ref]


Rare (less than 0.1%): Angioedema, erythema, pruritus, rash, hyperhidrosis, urticaria

Frequency not reported: Sweating increased


Frequency not reported: Photosensitivity reactions, skin vasculitis, toxic epidermal necrolysis, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, purpura, urticaria


Rare (less than 0.1%): Eczema, drug eruption, toxic skin eruption, toxicoderma, rash, angioedema

Frequency not reported: Dermatitis, sweating increased, pruritus

Postmarketing reports: Urticaria, erythema[Ref]


Rare (less than 0.1%): Abnormal hepatic function/liver disorder, hepatic enzyme increased

Frequency not reported: Serum bilirubin increased


Frequency not reported: Jaundice hepatocellular, jaundice cholestatic


Postmarketing reports: Abnormal hepatic function/liver disorder[Ref]


Rare (less than 0.1%): Visual disturbance, vision blurred


Frequency not reported: Xanthopsia, acute myopia, acute angle-closure glaucoma, transient blurred vision


Frequency not reported: Conjunctivitis, abnormal vision[Ref]



Frequency not reported: Anaphylactic reactions, hypersensitivity, allergy


Rare (less than 0.1%): Sepsis, hypersensitivity, anaphylactic reactions

Frequency not reported: Allergy, infection, fungal infection, abscess, otitis media[Ref]


1. "Product Information. Micardis (hydrochlorothiazide-telmisartan)." Boehringer-Ingelheim (2001):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.