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Hydrochlorothiazide / telmisartan Side Effects

In Summary

More frequently reported side effects include: dizziness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hydrochlorothiazide / telmisartan: oral tablet

Along with its needed effects, hydrochlorothiazide/telmisartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / telmisartan:

Less common

  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • confusion
  • convulsions
  • decreased urine
  • difficult, burning, or painful urination
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • dry mouth
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • frequent urge to urinate
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • lower back or side pain
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • sudden sweating
  • unusual tiredness or weakness

Less common or rare

  • Chills
  • cold sweats


  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Some side effects of hydrochlorothiazide / telmisartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • cough
  • difficulty breathing
  • dizziness
  • ear congestion
  • fever
  • headache
  • loss of voice
  • runny or stuffy nose
  • sneezing
  • sore throat

Less common

  • Abdominal or stomach pain
  • acid or sour stomach
  • back pain
  • belching
  • cough producing mucus
  • diarrhea
  • heartburn
  • hoarseness
  • indigestion
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • pain or tenderness around the eyes and cheekbones
  • rash
  • shivering
  • sweating
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble sleeping
  • trouble swallowing
  • voice changes

For Healthcare Professionals

Applies to hydrochlorothiazide / telmisartan: oral tablet


The most common adverse effect was upper respiratory tract infection.[Ref]


Common (1% to 10%): Sinusitis, upper respiratory tract infection, cough
Uncommon (0.1% to 1%): Dyspnea
Rare (less than 0.1%): Bronchitis, pharyngitis, respiratory distress, pneumonitis, pulmonary edema

Very common (10% or more): Upper respiratory tract infection (10%)
Common (1% to 10%): Sinusitis
Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema

Common (1% to 10%): Sinusitis, upper respiratory tract infection
Uncommon (0.1% to 1%): Cough
Frequency not reported: Asthma, rhinitis, dyspnea, epistaxis
Postmarketing reports: Interstitial lung disease[Ref]


Common (1% to 10%): Fatigue, influenza-like symptoms, pain
Uncommon (0.1% to 1%): Chest pain

Common (1% to 10%): Fatigue, influenza-like symptoms
Frequency not reported: Weakness, pyrexia

Common (1% to 10%): Fatigue, influenza-like symptoms
Uncommon (0.1% to 1%): Asthenia
Frequency not reported: Earache, fever, malaise, leg edema, peripheral edema, dependent edema, chest pain
Postmarketing reports: Weakness, edema, face edema, pain[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Syncope, paresthesia, vertigo

Common (1% to 10%): Dizziness
Frequency not reported: Lightheadedness

Common (1% to 10%): Dizziness
Rare (less than 0.1%): Somnolence
Frequency not reported: Tinnitus, migraine, hypoesthesia, cerebrovascular disorder, vertigo, paresthesia, hypoesthesia, involuntary muscle contraction
Postmarketing reports: Headache, syncope[Ref]


Common (1% to 10%): Diarrhea, nausea
Uncommon (0.1% to 1%): Dry mouth, flatulence
Rare (less than 0.1%): Abdominal pain, constipation, dyspepsia, vomiting, gastritis

Common (1% to 10%): Diarrhea, nausea
Frequency not reported: Sialadenitis, pancreatitis, stomach discomfort, cramping, gastric irritation

Common (1% to 10%): Diarrhea, nausea
Rare (less than 0.1%): Stomach discomfort
Frequency not reported: Hemorrhoids, gastroenteritis, enteritis, gastroesophageal reflux, toothache, non-specific gastrointestinal disorder, flatulence, constipation, gastritis, dry mouth,
Postmarketing reports: Dyspepsia, abdominal pain[Ref]


Common (1% to 10%): BUN increased 11.2 mg/dL or greater, serum creatinine increased 0.5 mg/dL or greater

Frequency not reported: Nephritis interstitial, renal dysfunction, renal failure

Uncommon (0.1% to 1%): Renal impairment, acute renal failure[Ref]


Common (1% to 10%): Urinary tract infection
Uncommon (0.1% to 1%): Erectile dysfunction
Frequency not reported: Impotence

Frequency not reported: Glycosuria

Uncommon (0.1% to 1%): Urinary tract infection
Frequency not reported: Micturition frequency, cystitis, impotence
Postmarketing reports: Erectile dysfunction[Ref]


Common (1% to 10%): Hemoglobin decreased 2 g/dL or greater
Uncommon (0.1% to 1%): Hematocrit decreased 9% or more

Frequency not reported: Aplastic anemia, hemolytic anemia, bone marrow depression, leukopenia, neutropenia, agranulocytosis, thrombocytopenia

Uncommon (0.1% to 1%): Anemia
Rare (less than 0.1%): Eosinophilia, thrombocytopenia, hemoglobin decreased[Ref]


Uncommon (0.1% to 1%): Tachycardia, arrhythmias, hypotension, orthostatic hypotension

Frequency not reported: Vasculitis necrotizing

Uncommon (0.1% to 1%): Bradycardia
Frequency not reported: Palpitation, angina pectoris, abnormal ECG, flushing, hypertension
Postmarketing reports: Atrial fibrillation, congestive heart failure, myocardial infarction, blood pressure increased, hypertension aggravated, hypotension, postural hypotension[Ref]


Uncommon (0.1% to 1%): Back pain, muscle spasm, myalgia
Rare (less than 0.1%): Arthralgia, muscle cramp, pain in limb, blood creatine phosphokinase increased
Frequency not reported: Leg pain, cramps in legs
Postmarketing reports: Exacerbation or activation of systemic lupus erythematosus

Frequency not reported: Lupus-like syndrome, muscle spasm

Rare (less than 0.1%): Arthrosis, tendon pain, tendonitis, tenosynovitis
Frequency not reported: Arthritis, arthralgia, leg pain, leg cramps, myalgia
Postmarketing reports: Back pain, muscle cramps, creatine phosphokinase increased, rhabdomyolysis[Ref]


Uncommon (0.1% to 1%): Hypokalemia, blood uric acid increased
Rare (less than 0.1%): Hyperuricemia, hyponatremia

Frequency not reported: Diabetes mellitus inadequate control, anorexia, appetite decreased, electrolyte imbalance, hypercholesterolemia, hyperglycemia, hypovolemia, triglycerides increased, hyperuricemia

Uncommon (0.1% to 1%): Hyperkalemia
Rare (less than 0.1%): Hypoglycemia in diabetic patients
Frequency not reported: Diabetes mellitus, gout, hypercholesterolemia
Postmarketing reports: Uric acid increased[Ref]


Uncommon (0.1% to 1%): Anxiety
Rare (less than 0.1%): Depression, insomnia, sleep disorder

Frequency not reported: Restlessness

Frequency not reported: Nervousness, insomnia, anxiety, depression[Ref]


Rare (less than 0.1%): Angioedema, erythema, pruritus, rash, hyperhidrosis, urticaria
Frequency not reported: Sweating increased

Frequency not reported: Photosensitivity reactions, skin vasculitis, toxic epidermal necrolysis, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, purpura, urticaria

Rare (less than 0.1%): Eczema, drug eruption, toxic skin eruption, toxicoderma, rash, angioedema
Frequency not reported: Dermatitis, sweating increased, pruritus
Postmarketing reports: Urticaria, erythema[Ref]


Rare (less than 0.1%): Abnormal hepatic function/liver disorder, hepatic enzyme increased
Frequency not reported: Serum bilirubin increased

Frequency not reported: Jaundice hepatocellular, jaundice cholestatic

Postmarketing reports: Abnormal hepatic function/liver disorder[Ref]


Rare (less than 0.1%): Visual disturbance, vision blurred

Frequency not reported: Xanthopsia, acute myopia, acute angle-closure glaucoma, transient blurred vision

Frequency not reported: Conjunctivitis, abnormal vision[Ref]


Frequency not reported: Anaphylactic reactions, hypersensitivity, allergy

Rare (less than 0.1%): Sepsis, hypersensitivity, anaphylactic reactions
Frequency not reported: Allergy, infection, fungal infection, abscess, otitis media[Ref]


1. "Product Information. Micardis (hydrochlorothiazide-telmisartan)" Boehringer-Ingelheim, Braintree, MA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.