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Hydrochlorothiazide / moexipril Side Effects

For the Consumer

Applies to hydrochlorothiazide / moexipril: oral tablet

In addition to its needed effects, some unwanted effects may be caused by hydrochlorothiazide / moexipril. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking hydrochlorothiazide / moexipril:

Less common:
  • Blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fast, slow, or irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • thirst
  • trembling
  • unusual tiredness or weakness
  • weakness and heaviness of the legs
  • wrinkled skin

Minor Side Effects

Some of the side effects that can occur with hydrochlorothiazide / moexipril may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Dry cough

For Healthcare Professionals

Applies to hydrochlorothiazide / moexipril: oral tablet


The most common adverse reactions were cough, dizziness, and fatigue.[Ref]


Common (1% to 10%): Fatigue, pain, flu syndrome, chest pain, peripheral edema, fever

Frequency not reported: Weakness[Ref]


Common (1% to 10%): Cough, upper respiratory infection, rhinitis, sinusitis, bronchitis

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, vertigo, hypertonia

Frequency not reported: Vertigo, dizziness, headache, paresthesia[Ref]


Common (1% to 10%): Diarrhea, abdominal pain, dyspepsia, nausea

Frequency not reported: Pancreatitis, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation[Ref]


Common (1% to 10%): Hyperuricemia, hyperglycemia, hypokalemia

Frequency not reported: Anorexia, hyperglycemia, hyperuricemia[Ref]


Common (1% to 10%): Urinary tract infection, impotence, pyuria

Frequency not reported: Glycosuria[Ref]


Common (1% to 10%): Rash

Frequency not reported: Stevens-Johnson syndrome, purpura, urticaria, rash, photosensitivity[Ref]


Common (1% to 10%): Abnormal ECG

Frequency not reported: Orthostatic hypotension, necrotizing angiitis[Ref]


Common (1% to 10%): Serum glutamic pyruvic transaminase (SGPT) increased

Frequency not reported: Intrahepatic cholestatic jaundice[Ref]


Common (1% to 10%): Back pain

Frequency not reported: Muscle spasm[Ref]


Common (1% to 10%): Infection[Ref]


Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia[Ref]


Frequency not reported: Transient blurred vision, xanthopsia[Ref]


Frequency not reported: BUN increased, serum creatinine increased[Ref]


Frequency not reported: Restlessness[Ref]


1. "Product Information. Uniretic (hydrochlorothiazide-moexipril)." Schwarz Pharma, Mequon, WI.

Not all side effects for hydrochlorothiazide / moexipril may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.