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Florinef Side Effects

Generic name: fludrocortisone

Medically reviewed by Last updated on May 22, 2023.

Note: This document contains side effect information about fludrocortisone. Some dosage forms listed on this page may not apply to the brand name Florinef.

Applies to fludrocortisone: oral tablets.

Side effects include:

Hypertension, edema, cardiac enlargement, CHF, potassium loss, hypokalemic alkalosis.

For Healthcare Professionals

Applies to fludrocortisone: compounding powder, oral tablet.


Most adverse reactions are caused by this drug's mineralocorticoid activity including retention of sodium and water, hypertension, edema, cardiac enlargement, congestive heart failure, potassium loss, and hypokalemic alkalosis.[Ref]


Frequency not reported: Hypertension, cardiac enlargement, congestive heart failure, thrombophlebitis, syncope, cardiomegaly, syncope[Ref]


Frequency not reported: Peptic ulcer, perforation, hemorrhage, pancreatitis, abdominal distention, ulcerative esophagitis, diarrhea[Ref]


Frequency not reported: Cushingoid state developed, growth suppression in children, secondary adrenocortical and pituitary unresponsiveness, carbohydrate tolerance decreased, manifestation of latent diabetes mellitus, insulin requirements increased, oral hypoglycemic agent requirements increased[Ref]


Frequency not reported: Hyperglycemia, negative nitrogen balance, potassium loss, hypokalemic alkalosis, sodium retention, fluid retention, appetite decreased[Ref]


Frequency not reported: Necrotizing angiitis, anaphylactoid reaction[Ref]


Frequency not reported: Muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathologic fracture of long bones, spontaneous fractures[Ref]


Frequency not reported: Posterior subcapsular cataract, intraocular pressure increased, glaucoma, exophthalmos[Ref]


Frequency not reported: Mental disturbance, insomnia[Ref]


Frequency not reported: Impaired wound healing, thin fragile skin, bruising, petechiae, ecchymoses, facial erythema, sweating increased, subcutaneous fat atrophy, purpura, striae, skin hyperpigmentation, nail hyperpigmentation, hirsutism, acneiform eruption, hives, reaction to skin tests suppressed, allergic skin rash, maculopapular rash, urticaria[Ref]


Frequency not reported: Menstrual irregularity, glycosuria[Ref]

Nervous system

Frequency not reported: Convulsion, intracranial pressure increased, papilledema, vertigo, headache, seizure, epilepsy[Ref]


Frequency not reported: Edema, infection aggravated, masking of infection[Ref]


1. "Product Information. Fludrocortisone Acetate (fludrocortisone)." Global Pharmaceutical Corporation (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.