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Florinef Acetate

Generic name: fludrocortisoneFLOO-droe-KOR-ti-sone ]
Drug class: Mineralocorticoids

Medically reviewed by on Aug 10, 2023. Written by Cerner Multum.

What is Florinef Acetate?

Florinef Acetate is a steroid that helps reduce inflammation in the body.

Florinef Acetate is used to treat conditions in which the body does not produce enough of its own steroids, such as Addison's disease, and salt-losing adrenogenital syndrome.

Florinef Acetate may also be used for purposes not listed in this medication guide.

Florinef Acetate side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Florinef Acetate may cause serious side effects. Call your doctor at once if you have:

Common side effects of Florinef Acetate may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not use Florinef Acetate if you have a fungal infection anywhere in your body.

Before taking this medicine

You should not use Florinef Acetate if you are allergic to it, or if you have a fungal infection anywhere in your body.

Florinef Acetate can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant. Taking Florinef Acetate during pregnancy may cause adrenal gland problems in the baby. Make sure any doctor caring for your pregnancy or your baby knows you haven taken this medicine during pregnancy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Florinef Acetate is not approved for use by anyone younger than 18 years old.

How should I take Florinef Acetate?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if Florinef Acetate is effective.

Your dose needs may change due to surgery, illness, stress, or a recent asthma attack. Do not change your medication dose or schedule without your doctor's advice.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Florinef Acetate.

You should not stop using Florinef Acetate suddenly. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light.

In case of emergency, wear or carry medical identification to let others know you use steroid medication.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include swelling, weight gain, feeling short of breath, leg cramps, irregular heartbeats, fluttering in your chest, muscle weakness, severe headache, or pounding in your neck or ears.

What should I avoid while taking Florinef Acetate?

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using Florinef Acetate.

Do not receive a smallpox vaccine while using Florinef Acetate. Ask your doctor before receiving any other vaccines while you are taking Florinef Acetate.

What other drugs will affect Florinef Acetate?

Tell your doctor about all your current medicines. Many drugs can affect Florinef Acetate, especially:

This list is not complete and many other drugs may affect Florinef Acetate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.