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Ezogabine Side Effects

In Summary

Commonly reported side effects of ezogabine include: ataxia, blurred vision, confusion, dizziness, drowsiness, fatigue, tremor, hallucination, and skin discoloration. Other side effects include: abnormal gait, anxiety, aphasia, asthenia, constipation, diplopia, disorientation, dysarthria, dysuria, equilibrium disturbance, influenza, memory impairment, nausea, paresthesia, urinary hesitancy, and vertigo. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ezogabine: oral tablet

In addition to its needed effects, some unwanted effects may be caused by ezogabine. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking ezogabine:

More common:
  • Decrease in the frequency of urination
  • decrease in the urine volume
  • difficulty with passing urine (dribbling)
  • painful urination
  • shakiness in the legs, arms, hands, or feet
Less common:
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine
  • burning while urinating
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • difficult urination
  • general feeling of discomfort or illness
  • muscle twitching or jerking
  • rapid weight gain
  • rhythmic movement of the muscles
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
Incidence not known:
  • Agitation
  • back pain
  • black, tarry stools
  • bleeding gums
  • blurred vision
  • change in consciousness
  • chest pain
  • chills
  • cloudy urine
  • confusion
  • cough
  • difficult or labored breathing
  • dizziness
  • drowsiness
  • fainting
  • fever
  • headache
  • irritability
  • loss of consciousness
  • pain in the lower back or side
  • pinpoint red spots on the skin
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiff neck
  • swollen glands
  • tightness in the chest
  • unusual bleeding or bruising
  • vomiting

Minor Side Effects

Some of the side effects that can occur with ezogabine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Being forgetful
  • clumsiness or unsteadiness
  • dizziness or lightheadedness
  • double vision
  • feeling of constant movement of self or surroundings
  • seeing double
  • sensation of spinning
  • sleepiness or unusual drowsiness
Less common:
  • Absence of or decrease in the body movement
  • acid or sour stomach
  • belching
  • changes in patterns and rhythms of speech
  • confusion about identity, place, and time
  • cough
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with swallowing
  • dry mouth
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • feeling, seeing, or hearing things that are not there
  • heartburn
  • increased appetite
  • increased sweating
  • indigestion
  • joint pain
  • lack or loss of strength
  • loss of appetite
  • loss of memory
  • muscle aches and pains
  • problems with speech or speaking
  • runny nose
  • severe mood or mental changes
  • shivering
  • slurred speech
  • stomach discomfort, upset, or pain
  • sweating
  • trouble sleeping
  • trouble walking
  • unusual behavior
  • weight gain
Incidence not known:
  • False or unusual sense of wellbeing
  • hair loss or thinning of the hair
  • muscle spasms
  • rash
  • uncontrolled eye movements

For Healthcare Professionals

Applies to ezogabine: oral tablet


Very common (10% or more): Retinal pigmentary abnormalities (up to 30%)
Common (1% to 10%): Diplopia, blurred vision
Frequency not reported: Decreased visual acuity, nystagmus
Postmarketing reports: Acquired vitelliform lesions[Ref]


Very common (10% or more): Discoloration of the skin, palate, scleral, nail, conjunctiva, lip, and/or mucous membrane (up to 40%)
Uncommon (0.1% to 1%): Hyperhidrosis, skin rash
Frequency not reported: Alopecia[Ref]


Common (1% to 10%): Confusional state, psychotic disorders, hallucinations, anxiety, disorientation
Frequency not reported: Euphoric mood[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 23%), somnolence (up to 22%)
Common (1% to 10%): Memory impairment, tremor, vertigo, abnormal coordination, disturbance in attention, gait disturbance, aphasia, dysarthria, balance disorder, paresthesia, amnesia, myoclonus
Frequency not reported: Syncope, coma, encephalopathy[Ref]


Common (1% to 10%): Urinary retention, urinary hesitation, dysuria, hematuria, chromaturia[Ref]


Common (1% to 10%): Nausea, constipation, dyspepsia, dry mouth
Uncommon (0.1% to 1%): Dysphasia[Ref]


Frequency not reported: Leukopenia, neutropenia, thrombocytopenia[Ref]


Common (1% to 10%): Increased liver enzymes (less than 2%)
Frequency not reported: Nephrolithiasis[Ref]


Common (1% to 10%): Influenza[Ref]


Common (1% to 10%): Increased weight, increased appetite[Ref]


Uncommon (0.1% to 1%): Hypokinesia
Frequency not reported: Muscle spasms[Ref]


Very common (10% or more): Fatigue (up to 15%)
Common (1% to 10%): Asthenia, malaise, peripheral edema[Ref]


Uncommon (0.1% to 1%): Nephrolithiasis
Frequency not reported: Renal colic[Ref]


Frequency not reported: Dyspnea[Ref]


1. "Product Information. Potiga (ezogabine)." GlaxoSmithKline, Research Triangle Park, NC.

Not all side effects for ezogabine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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