Edarbyclor Side Effects

Generic name: azilsartan medoxomil / chlorthalidone

Medically reviewed by Drugs.com. Last updated on Feb 19, 2025.

Note: This document provides detailed information about Edarbyclor Side Effects associated with azilsartan medoxomil / chlorthalidone. Some dosage forms listed on this page may not apply specifically to the brand name Edarbyclor.

Applies to azilsartan medoxomil / chlorthalidone: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position or after the first dose of this medicine. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, call your doctor right away.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water and which may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

Hypokalemia (low potassium in the blood) may occur after using this medicine. Check with your doctor right away if you have any of the following symptoms: dry mouth, increased thirst, muscle cramps, nausea, or vomiting.

Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.

Common side effects of Edarbyclor

Some side effects of azilsartan medoxomil / chlorthalidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Edarbyclor

Along with its needed effects, azilsartan medoxomil / chlorthalidone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking azilsartan medoxomil / chlorthalidone:

For healthcare professionals

Applies to azilsartan medoxomil / chlorthalidone: oral tablet.

General adverse events

The most common side effects were dizziness and fatigue.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness
• Uncommon (0.1% to 1%): Syncope
• Postmarketing reports: Loss of consciousness

Azilsartan:

• Common (1% to 10%): Dizziness
• Frequency not reported: Dizziness postural

Chlorthalidone:

• Common (1% to 10%): Dizziness
• Frequency not reported: Headache^[Ref]

Other

• Common (1% to 10%): Fatigue

Azilsartan:

• Uncommon (0.1% to 1%): Fatigue
• Frequency not reported: Asthenia

Chlorthalidone:

• Common (1% to 10%): Fatigue^[Ref]

Renal

• Common (1% to 10%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal

Azilsartan:

• Uncommon (0.1% to 1%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal

Chlorthalidone:

• Uncommon (0.1% to 1%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal^[Ref]

Gastrointestinal

• Postmarketing reports: Nausea

Azilsartan:

• Frequency not reported: Diarrhea, nausea

Chlorthalidone:

• Frequency not reported: Gastrointestinal upset^[Ref]

Cardiovascular

• Common (1% to 10%): Hypotension^[Ref]

Dermatologic

• Postmarketing reports: Rash, pruritus, angioedema

Chlorthalidone:

• Frequency not reported: Rash^[Ref]

Hepatic

Chlorthalidone:

• Frequency not reported: Cholesterol elevated^[Ref]

Metabolic

• Frequency not reported: BUN increased

Chlorthalidone:

• Frequency not reported: Uric acid elevated^[Ref]

Musculoskeletal

Azilsartan:

• Frequency not reported: Muscle spasm^[Ref]

Respiratory

Azilsartan:

• Frequency not reported: Cough^[Ref]

See also:

Further information

Edarbyclor side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer