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Edarbyclor Side Effects

Generic Name: azilsartan medoxomil / chlorthalidone

Note: This document contains side effect information about azilsartan medoxomil / chlorthalidone. Some of the dosage forms listed on this page may not apply to the brand name Edarbyclor.

For the Consumer

Applies to azilsartan medoxomil / chlorthalidone: oral tablet

Along with its needed effects, azilsartan medoxomil/chlorthalidone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking azilsartan medoxomil / chlorthalidone:

Less common
  • Blurred vision
  • confusion
  • convulsions
  • decreased urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • sweating
  • unusual tiredness or weakness
Incidence not known
  • Ankle, knee, or great toe joint pain
  • joint stiffness or swelling
  • lower back, side, or stomach pain
  • swelling of the feet or lower legs

Some side effects of azilsartan medoxomil / chlorthalidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dizziness
Rare
  • Cough
  • diarrhea
  • lack or loss of strength
  • muscle spasm
Incidence not known
  • Headache
  • loss of appetite
  • rash
  • stomach cramps

For Healthcare Professionals

Applies to azilsartan medoxomil / chlorthalidone: oral tablet

General

The most common side effects were dizziness and fatigue.[Ref]

Nervous system

Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Syncope
Postmarketing reports: Loss of consciousness

Azilsartan:
Common (1% to 10%): Dizziness
Frequency not reported: Dizziness postural

Chlorthalidone:
Common (1% to 10%): Dizziness
Frequency not reported: Headache[Ref]

Other

Common (1% to 10%): Fatigue

Azilsartan:
Uncommon (0.1% to 1%): Fatigue
Frequency not reported: Asthenia

Chlorthalidone:
Common (1% to 10%): Fatigue[Ref]

Renal

Common (1% to 10%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal

Azilsartan:
Uncommon (0.1% to 1%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal

Chlorthalidone:
Uncommon (0.1% to 1%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal[Ref]

Gastrointestinal

Postmarketing reports: Nausea

Azilsartan:
Frequency not reported: Diarrhea, nausea

Chlorthalidone:
Frequency not reported: Gastrointestinal upset[Ref]

Cardiovascular

Common (1% to 10%): Hypotension[Ref]

Dermatologic

Postmarketing reports: Rash, pruritus, angioedema

Chlorthalidone:
Frequency not reported: Rash[Ref]

Hepatic

Chlorthalidone:
Frequency not reported: Cholesterol elevated[Ref]

Metabolic

Frequency not reported: BUN increased

Chlorthalidone:
Frequency not reported: Uric acid elevated[Ref]

Musculoskeletal

Azilsartan:
Frequency not reported: Muscle spasm[Ref]

Respiratory

Azilsartan:
Frequency not reported: Cough[Ref]

References

1. "Product Information. Edarbyclor (azilsartan-chlorthalidone)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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