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Dobutamine Side Effects

For the Consumer

Applies to dobutamine: parenteral concentrate for injection for iv infusion, parenteral injection in 5% dextrose for iv infusion

Side effects include:

Ectopic heartbeats, increased heart rate, elevations in BP, hypotension, phlebitis, local inflammatory changes.

For Healthcare Professionals

Applies to dobutamine: intravenous solution

General

The most common adverse reaction was heart rate increased by 30 beats per minute or more.[Ref]

Cardiovascular

Very common (10% or more): Heart rate increased by 30 beats per minute (bpm) or more (10%)

Common (1% to 10%): Systolic blood pressure increased by 50 mmHg or more, premature ventricular beats increased, anginal pain, palpitations, blood pressure decreased, ventricular dysrhythmia, dose-dependent ventricular extrasystoles, ventricular frequency increased in patients with atrial fibrillation, vasoconstriction in patients previously treated with beta blockers, supraventricular extrasystoles, ventricular tachycardia

Uncommon (0.1% to 1%): Ventricular fibrillation

Very rare (less than 0.01%): Bradycardia, myocardial ischemia, myocardial infarction, cardiac arrest, second degree atrioventricular block, coronary vasospasms, hypertensive/hypotensive blood pressure decompensation, intracavitary pressure gradients

Frequency not reported: Systolic blood pressure increased by 10 to 20 mmHg, heart rate increased by 5 to 15 bpm, blood pressure decreased precipitously, pulmonary capillary pressure decreased, pectoral anginal discomfort, stress cardiomyopathy, eosinophilic myocarditis, fatal cardiac rupture[Ref]

Dermatologic

Common (1% to 10%): Exanthema, skin rash

Very rare (less than 0.01%): Petechial bleeding

Frequency not reported: Pruritus of the scalp[Ref]

Local

Common (1% to 10%): Phlebitis, inflammation

Very rare (less than 0.01%): Cutaneous necrosis[Ref]

Hematologic

Common (1% to 10%): Eosinophilia, thrombocyte aggregation inhibited when continuing infusion over a number of days

Frequency not reported: Thrombocytopenia[Ref]

Other

Common (1% to 10%): Nonspecific chest pain, fever

Frequency not reported: Feeling of heat and anxiety[Ref]

Respiratory

Common (1% to 10%): Shortness of breath, bronchospasm[Ref]

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Paresthesia, tremor[Ref]

Genitourinary

Common (1% to 10%): Urgency increased at high doses of infusion

Frequency not reported: Urinary urgency[Ref]

Gastrointestinal

Common (1% to 10%): Nausea[Ref]

Metabolic

Very rare (less than 0.01%): Hypokalemia

Frequency not reported: Serum potassium decreased[Ref]

Immunologic

Frequency not reported: Hypersensitivity[Ref]

Musculoskeletal

Frequency not reported: Myoclonic spasm[Ref]

Psychiatric

Frequency not reported: Restlessness, anxiety[Ref]

References

1. "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company, Indianapolis, IN.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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