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Dobutamine Side Effects

In Summary

Commonly reported side effects of dobutamine include: increased heart rate. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dobutamine: parenteral concentrate for injection for iv infusion, parenteral injection for iv infusion

Side effects include:

Ectopic heartbeats, increased heart rate, elevations in BP, hypotension, phlebitis, local inflammatory changes.

For Healthcare Professionals

Applies to dobutamine: intravenous solution

General

The most common adverse reaction was heart rate increased by 30 beats per minute or more.[Ref]

Cardiovascular

Very common (10% or more): Heart rate increased by 30 beats per minute (bpm) or more (10%)
Common (1% to 10%): Systolic blood pressure increased by 50 mmHg or more, premature ventricular beats increased, anginal pain, palpitations, blood pressure decreased, ventricular dysrhythmia, dose-dependent ventricular extrasystoles, ventricular frequency increased in patients with atrial fibrillation, vasoconstriction in patients previously treated with beta blockers, supraventricular extrasystoles, ventricular tachycardia
Uncommon (0.1% to 1%): Ventricular fibrillation
Very rare (less than 0.01%): Bradycardia, myocardial ischemia, myocardial infarction, cardiac arrest, second degree atrioventricular block, coronary vasospasms, hypertensive/hypotensive blood pressure decompensation, intracavitary pressure gradients
Frequency not reported: Systolic blood pressure increased by 10 to 20 mmHg, heart rate increased by 5 to 15 bpm, blood pressure decreased precipitously, pulmonary capillary pressure decreased, pectoral anginal discomfort, stress cardiomyopathy, eosinophilic myocarditis, fatal cardiac rupture[Ref]

Dermatologic

Common (1% to 10%): Exanthema, skin rash
Very rare (less than 0.01%): Petechial bleeding
Frequency not reported: Pruritus of the scalp[Ref]

Local

Common (1% to 10%): Phlebitis, inflammation
Very rare (less than 0.01%): Cutaneous necrosis[Ref]

Hematologic

Common (1% to 10%): Eosinophilia, thrombocyte aggregation inhibited when continuing infusion over a number of days
Frequency not reported: Thrombocytopenia[Ref]

Other

Common (1% to 10%): Nonspecific chest pain, fever
Frequency not reported: Feeling of heat and anxiety[Ref]

Respiratory

Common (1% to 10%): Shortness of breath, bronchospasm[Ref]

Nervous system

Common (1% to 10%): Headache
Frequency not reported: Paresthesia, tremor[Ref]

Genitourinary

Common (1% to 10%): Urgency increased at high doses of infusion
Frequency not reported: Urinary urgency[Ref]

Gastrointestinal

Common (1% to 10%): Nausea[Ref]

Metabolic

Very rare (less than 0.01%): Hypokalemia
Frequency not reported: Serum potassium decreased[Ref]

Immunologic

Frequency not reported: Hypersensitivity[Ref]

Musculoskeletal

Frequency not reported: Myoclonic spasm[Ref]

Psychiatric

Frequency not reported: Restlessness, anxiety[Ref]

References

1. "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company, Indianapolis, IN.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for dobutamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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