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Dextrostat Side Effects

Generic name: dextroamphetamine

Medically reviewed by Drugs.com. Last updated on Sep 14, 2022.

Note: This document contains side effect information about dextroamphetamine. Some dosage forms listed on this page may not apply to the brand name Dextrostat.

Applies to dextroamphetamine: transdermal patch extended release.

Warning

Transdermal route (Patch, Extended Release)

CNS stimulants, including dextroamphetamine, other amphetamine-containing products, and methylphenidate, have high potential for abuse and dependence. Assess the risk of abuse prior to prescribing and monitor for signs of abuse and dependence while on therapy.

Serious side effects of Dextrostat

Along with its needed effects, dextroamphetamine (the active ingredient contained in Dextrostat) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dextroamphetamine:

More common

  • Black, tarry stools
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • sore throat
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Increased heart rate
  • increase in blood pressure

Incidence not known

  • Anger
  • bladder pain
  • blistering, burning, crusting, dryness, flaking, peeling, or loosening of the skin
  • bloody nose
  • bloody or cloudy urine
  • bloody vomit
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain, discomfort, or tightness
  • dark urine
  • delusions of persecution, mistrust, suspiciousness, or combativeness
  • diarrhea
  • difficulty in speaking
  • discouragement
  • dizziness
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fear, nervousness
  • feeling sad or empty
  • frequent urge to urinate
  • hives, itching, skin rash
  • irritability
  • joint or muscle pain
  • lack of appetite
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of interest or pleasure
  • mood swings
  • muscle cramps, spasms, pain, or stiffness
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • paleness or cold feeling in the fingertips and toes
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red irritated eyes
  • red skin lesions, often with a purple center
  • restlessness
  • scaling, severe redness, soreness, or swelling of the skin
  • seizures
  • severe stomach pain
  • shakiness in the legs, arms, hands, or feet
  • sleepiness or unusual drowsiness
  • sweating
  • swelling of the feet or lower legs
  • tingling or pain in the fingers or toes when exposed to cold
  • trembling or shaking of the hands or feet
  • trouble concentrating
  • trouble sleeping
  • twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • upper right abdominal or stomach pain
  • vomiting
  • weight decreased
  • yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking dextroamphetamine:

Symptoms of overdose

  • Aggressive
  • angry
  • confusion
  • dark urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast breathing
  • fast, slow, or irregular heartbeat
  • loss of consciousness
  • muscle cramps, spasms, pain, or stiffness
  • nausea
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • seizures
  • stomach cramps
  • sweating
  • tremor
  • unusual tiredness or weakness
  • vomiting

Other side effects of Dextrostat

Some side effects of dextroamphetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence not known

  • Bigger, dilated, or enlarged pupils (black part of eye)
  • change in taste
  • constipation
  • decreased interest in sexual intercourse
  • double vision
  • inability to have or keep an erection
  • increased sensitivity of the eyes to light
  • loss in sexual ability, desire, drive, or performance
  • loss of taste
  • loss or thinning of the hair
  • seeing double

For Healthcare Professionals

Applies to dextroamphetamine: oral capsule extended release, oral solution, oral tablet, transdermal film.

Metabolic

Very common (10% or more): Decreased appetite, reduced weight gain, weight loss

Common (1% to 10%): Anorexia

Frequency not reported: Acidosis[Ref]

Psychiatric

Very common (10% or more): Insomnia, nervousness

Common (1% to 10%): Abnormal behavior, aggression/hostility, excitation, anxiety, depression, irritability

Uncommon (0.1% to 1%): Psychotic episodes/psychosis

Very rare (less than 0.01%): Suicidal behavior (including completed suicide), mania, hallucinations

Frequency not reported: Overstimulation, restlessness, euphoria, dysphoria, confusion, dependence, emotional lability, impaired cognitive test performance, altered libido, night terrors, obsessive-compulsive behavior, panic states, paranoia[Ref]

Cardiovascular

Common (1% to 10%): Arrhythmia, palpitations, tachycardia

Rare (less than 0.1%): Angina pectoris

Very rare (less than 0.01%): Cardiac arrest

Frequency not reported: Blood pressure and heart rate changes (usually elevated), cardiomyopathy, myocardial infarction, chest pain, cardiovascular collapse, Raynaud's phenomenon[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain and cramps, nausea, vomiting, dry mouth

Frequency not reported: Ischemic colitis, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia

Rare (less than 0.1%): Growth retardation

Very rare (less than 0.01%): Muscle cramps

Frequency not reported: Rhabdomyolysis[Ref]

Nervous system

Common (1% to 10%): Vertigo, dyskinesia, headache, hyperactivity

Very rare (less than 0.01%): Tourette syndrome, tics, exacerbation of pre-existing motor and phonic tics, convulsions, choreoathetoid movements, intracranial hemorrhage, cerebral vasculitis and/or occlusion, neuroleptic malignant syndrome (NMS)

Frequency not reported: Dizziness, tremor, ataxia, dysgeusia, concentration difficulties, hyperreflexia, stroke[Ref]

Dermatologic

Rare (less than 0.1%): Rash, urticaria

Very rare (less than 0.01%): Erythema multiforme, exfoliative dermatitis, fixed drug eruption

Frequency not reported: Sweating, alopecia[Ref]

Ocular

Rare (less than 0.1%): Visual accommodation difficulties, blurred vision, mydriasis[Ref]

Other

Rare (less than 0.1%): Fatigue

Frequency not reported: Hyperpyrexia, sudden death[Ref]

Hematologic

Very rare (less than 0.01%): Anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura[Ref]

Hepatic

Very rare (less than 0.01%): Abnormal liver function ranging from hepatic enzyme elevations to hepatic coma[Ref]

Endocrine

Frequency not reported: Impotence, libido changes, frequent or prolonged erections[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions (e.g., angioedema and anaphylaxis)[Ref]

Renal

Frequency not reported: Renal damage[Ref]

Frequently asked questions

More about Dextrostat (dextroamphetamine)

Patient resources

Other brands

Dexedrine, Zenzedi, Xelstrym, Liquadd, ProCentra

Professional resources

Related treatment guides

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Dexedrine (dextroamphetamine)." SmithKline Beecham (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.