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Cotab AX Side Effects

Generic Name: chlorpheniramine / codeine

Note: This document contains side effect information about chlorpheniramine / codeine. Some of the dosage forms listed on this page may not apply to the brand name Cotab AX.

For the Consumer

Applies to chlorpheniramine / codeine: oral suspension extended release

Along with its needed effects, chlorpheniramine/codeine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlorpheniramine / codeine:

Incidence not known

  • Anxiety
  • belching
  • bloating
  • blurred or loss of vision
  • chills
  • cold clammy skin
  • cold sweats
  • confusion
  • dark colored urine
  • depression
  • diarrhea
  • difficult or painful urination
  • disturbed color perception
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • double vision
  • dryness or spasm of the throat
  • feeling of constant movement of self or surroundings
  • fever
  • halos around lights
  • headache
  • heartburn
  • increased hunger
  • indigestion
  • irregular, fast or slow, or shallow breathing
  • loss of appetite
  • nausea
  • nervousness
  • night blindness
  • nightmares
  • overbright appearance of lights
  • pain in the stomach, side, or abdomen, possibly radiating to the back
  • pain or discomfort in the chest, upper stomach, or throat
  • pale or blue lips, fingernails, or skin
  • pressure in the stomach
  • pounding in the ears
  • seizures
  • sensation of spinning
  • shakiness
  • sleepiness or unusual drowsiness
  • slow, fast, or irregular heartbeat
  • slurred speech
  • stomach discomfort, upset, or pain
  • sweating
  • tunnel vision
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin

Some side effects of chlorpheniramine / codeine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Anxiety
  • blistering, crusting, or irritation of the skin
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cracked, dry, scaly skin
  • dry mouth
  • early menstrual periods
  • face is warm or hot to touch
  • false or unusual sense of well-being
  • general feeling of discomfort or illness
  • hearing loss
  • hiccups
  • increased appetite
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • irritability
  • lack or loss of strength
  • redness of the face
  • restlessness
  • skin rash, itching, redness, hives, swelling
  • swelling of the breasts or breast soreness in both females and males
  • trouble sleeping
  • twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • watering of the eyes

For Healthcare Professionals

Applies to chlorpheniramine / codeine: oral liquid, oral suspension, oral suspension extended release, oral tablet

Cardiovascular

Codeine or Chlorpheniramine:
Frequency not reported: Fast, or slow heartbeat, hypertension, hypotension, orthostatic hypotension, palpitations, shock-like state, syncope[Ref]

Nervous system

Codeine or Chlorpheniramine:
Frequency not reported: Weakness, dizziness, drowsiness, sedation, headache, facial dyskinesia, lightheadedness, somnolence, dyskinesia, tremor[Ref]

Gastrointestinal

Codeine or Chlorpheniramine:
Frequency not reported: Nausea, vomiting, constipation, abdominal distension, abdominal pain, acute pancreatitis, dry mouth, dyspepsia, epigastric distress, diarrhea, gastro-esophageal reflux, gastrointestinal hypomotility[Ref]

Respiratory

Codeine:
Frequency not reported: Respiratory depression, dryness of the pharynx and respiratory passages, laryngismus, atelectasis, wheezing, troubled breathing, hiccups[Ref]

Endocrine

Codeine or Chlorpheniramine:
Frequency not reported: Decreased lactation, early menses, gynecomastia, increased libido, pheochromocytoma stimulation[Ref]

Dermatologic

Codeine or Chlorpheniramine:
Frequency not reported: Redness or flushing of face, skin rash, pruritus, erythema, urticaria, excessive perspiration, dermatitis[Ref]

Hypersensitivity

Codeine or Chlorpheniramine:
Frequency not reported: Allergic laryngospasm, nasal stuffiness, bronchospastic allergic reaction, hives, itching, swelling of face[Ref]

Ocular

Codeine or Chlorpheniramine:
Frequency not reported: Blurred vision, diplopia, visual disturbances, hypermetropia, lacrimation increased, mydriasis, photophobia[Ref]

General

The more commonly reported adverse effects have included nausea, vomiting, constipation, blurred vision, confusion, dizziness, depression, drowsiness, headache, lightheadedness, insomnia, irritability, and tremor.[Ref]

Other

Codeine or Chlorpheniramine:
Frequency not reported: Asthenia, feeling of relaxation, unusual tiredness, labyrinthitis, tinnitus, vertigo[Ref]

Metabolic

Codeine or Chlorpheniramine:
Frequency not reported: Changes in glucose utilization, glycosuria, hypoglycemia, increased appetite, loss of appetite[Ref]

Psychiatric

Codeine:
Frequency not reported: Drug dependence, confusion, depression, euphoria, false sense of well-being, excitability, nervousness, agitation, restlessness, insomnia, irritability[Ref]

References

1. "Product Information. Tuzistra XR (chlorpheniramine-codeine)." Vernalis Pharmaceuticals Inc, Morristown, NJ.

2. "Product Information. Zodryl AC Adult (chlorpheniramine-codeine)." codaDOSE Incorporated, Flowery Branch [Atlanta], GA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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