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Corzide Side Effects

Generic Name: bendroflumethiazide / nadolol

Note: This document contains side effect information about bendroflumethiazide / nadolol. Some of the dosage forms listed on this page may not apply to the brand name Corzide.

For the Consumer

Applies to bendroflumethiazide / nadolol: oral tablet

Along with its needed effects, bendroflumethiazide / nadolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bendroflumethiazide / nadolol:

Less common
  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • confusion
  • cough
  • difficulty breathing
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • extreme fatigue
  • irregular breathing
  • lightheadedness, dizziness, or fainting
  • noisy breathing
  • paleness or cold feeling in fingertips and toes
  • shortness of breath
  • slow or irregular heartbeat
  • slurred speech
  • sweating
  • swelling of face, fingers, feet, or lower legs
  • tightness in chest
  • tingling or pain in fingers or toes when exposed to cold
  • unusual tiredness or weakness
  • weight gain
  • wheezing
Incidence not determined
  • Back or leg pains
  • black, tarry stools
  • bleeding gums
  • bloating
  • blood in urine or stools
  • chills
  • clay-colored stools
  • cloudy urine
  • cold sweats
  • constipation
  • coughing up blood
  • dark urine
  • difficulty swallowing
  • drowsiness
  • dry mouth
  • fast heartbeat
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • general body swelling
  • general feeling of discomfort or illness
  • general tiredness and weakness
  • headache
  • hives
  • hoarseness
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • joint pain, stiffness, or swelling
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • muscle tremors
  • nausea and vomiting
  • nosebleeds
  • pain in muscles
  • painful or difficult urination
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • pinpoint red spots on skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid, deep breathing
  • rash
  • redness, soreness, or itching skin
  • restlessness
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • sores, welting or blisters
  • stomach cramps
  • sugar in the urine
  • swollen or painful glands
  • tenderness of salivary glands
  • thickening of bronchial secretions
  • troubled breathing
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual weight loss
  • upper right abdominal pain
  • vomiting of blood
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking bendroflumethiazide / nadolol:

Symptoms of overdose
  • Change in consciousness
  • decreased urination
  • diarrhea
  • fast, slow, or shallow breathing
  • gas
  • heartburn
  • increase in heart rate
  • increased sweating
  • indigestion
  • loss of consciousness
  • low blood pressure
  • muscle cramps
  • numbness, tingling, pain, or weakness in hands or feet
  • pale or blue lips, fingernails, or skin
  • seizures
  • sunken eyes
  • trembling
  • unusual drowsiness, dullness, or feeling of sluggishness
  • unusual paleness
  • weakness and heaviness of legs
  • wrinkled skin

Some side effects of bendroflumethiazide / nadolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Change in behavior
  • continuing ringing or buzzing or other unexplained noise in ears
  • decreased interest in sexual intercourse
  • dry eyes or skin
  • excess air or gas in stomach or intestines
  • hair loss, thinning of hair
  • hearing loss
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • relaxed and calm
  • sleepiness
  • stomach soreness or discomfort
  • stuffy nose
  • weight loss
Incidence not determined
  • Cracks in the skin
  • discoloration of skin
  • feeling of constant movement of self or surroundings
  • increased sensitivity of skin to sunlight
  • large, flat, blue or purplish patches in the skin
  • loss of heat from the body
  • muscle spasm, weakness, or restlessness
  • scaly skin
  • sensation of spinning
  • severe sunburn

For Healthcare Professionals

Applies to bendroflumethiazide / nadolol: oral tablet

Cardiovascular

Bendroflumethiazide:
Frequency not reported: Necrotizing angiitis, vasculitis, orthostatic hypotension

Nadolol:
Common (1% to 10%): Heart rate less than 40 beats per minute (bpm), symptoms of peripheral vascular insufficiency, cardiac failure, hypotension, rhythm/conduction disturbances
Frequency not reported: Heart rate less than 60 bpm, first degree heart block, third degree heart block[Ref]

Nervous system

Bendroflumethiazide:
Frequency not reported: Dizziness, vertigo, paresthesia, headache

Nadolol:
Common (1% to 10%): Dizziness/fatigue
Uncommon (0.1% to 1%): Paresthesias, sedation, headache, tinnitus, slurred speech[Ref]

Gastrointestinal

Bendroflumethiazide:
Frequency not reported: Nausea, vomiting, cramping, diarrhea, constipation, gastric irritation, abdominal bloating, sialadenitis, pancreatitis

Nadolol:
Uncommon (0.1% to 1%): Nausea, diarrhea, abdominal discomfort, constipation, vomiting, indigestion, bloating, flatulence, dry mouth[Ref]

Dermatologic

Bendroflumethiazide:
Frequency not reported: Purpura, exfoliative dermatitis, pruritus, ecchymosis, urticaria, cutaneous vasculitis, photosensitivity, rash

Nadolol:
Uncommon (0.1% to 1%): Rash, pruritus, dry skin, sweating, facial swelling
Frequency not reported: Reversible alopecia[Ref]

Respiratory

Bendroflumethiazide:
Frequency not reported: Respiratory distress, pneumonitis

Nadolol:
Uncommon (0.1% to 1%): Bronchospasm, cough, nasal stuffiness[Ref]

Metabolic

Bendroflumethiazide:
Frequency not reported: Anorexia, hyperglycemia, metabolic acidosis, hyperuricemia

Nadolol:
Uncommon (0.1% to 1%): Anorexia, weight gain[Ref]

Ocular

Bendroflumethiazide:
Frequency not reported: Xanthopsia, transient blurred vision

Nadolol:
Uncommon (0.1% to 1%): Dry eyes, blurred vision[Ref]

Psychiatric

Bendroflumethiazide:
Frequency not reported: Restlessness

Nadolol:
Uncommon (0.1% to 1%): Change in behavior, impotence or decreased libido[Ref]

Hematologic

Bendroflumethiazide:
Frequency not reported: Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia[Ref]

Hepatic

Bendroflumethiazide:
Frequency not reported: Intrahepatic cholestatic jaundice, hepatitis[Ref]

Immunologic

Bendroflumethiazide:
Frequency not reported: Anaphylactic reactions, allergic glomerulonephritis[Ref]

Other

Bendroflumethiazide:
Frequency not reported: Fever, weakness[Ref]

Genitourinary

Bendroflumethiazide:
Frequency not reported: Glycosuria[Ref]

Musculoskeletal

Bendroflumethiazide:
Frequency not reported: Muscle spasm[Ref]

References

1. "Product Information. Corzide (bendroflumethiazide-nadolol)" Bristol-Myers Squibb, Princeton, NJ.

Some side effects of Corzide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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