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Coreg CR Side Effects

Generic Name: carvedilol

Note: This page contains information about the side effects of carvedilol. Some of the dosage forms included on this document may not apply to the brand name Coreg CR.

In Summary

Common side effects of Coreg CR include: hyperglycemia. Other side effects include: angina pectoris, hypotension, nausea, orthostatic hypotension, rales, visual disturbance, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to carvedilol: oral capsule extended release, oral tablet

In addition to its needed effects, some unwanted effects may be caused by carvedilol (the active ingredient contained in Coreg CR). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking carvedilol:

More common:
  • Allergy
  • chest pain, discomfort, tightness, or heaviness
  • dizziness, lightheadedness, or fainting
  • generalized swelling or swelling of the feet, ankles, or lower legs
  • pain
  • shortness of breath
  • slow heartbeat
  • weight gain
Less common:
  • Ankle, knee, or great toe joint pain
  • anxiety
  • arm, back, or jaw pain
  • blood in the urine
  • bloody, black or tarry stools
  • chills
  • cloudy urine
  • cold sweats
  • coma
  • confusion
  • convulsions
  • cool pale skin
  • cough
  • dark urine
  • decreased appetite
  • decreased frequency or amount of urine
  • depression
  • difficulty with breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying position
  • dry mouth
  • fainting
  • fast or irregular heartbeat
  • fever
  • flu-like symptoms
  • flushed, dry skin
  • fruit-like breath odor
  • headache, sudden and severe
  • inability to speak
  • increased blood pressure
  • increased hunger
  • increased thirst
  • increased urination
  • itching
  • joint stiffness or swelling
  • large amount of cholesterol in the blood
  • loss of appetite
  • loss of consciousness
  • lower back, side, or stomach pain
  • mental depression
  • muscle pain or cramps
  • nervousness
  • nightmares
  • noisy, rattling breathing
  • numbness or tingling in the hands, feet, or lips
  • pinpoint red or purple spots on the skin
  • pounding in the ears
  • pounding, slow heartbeat
  • rapid breathing
  • seizures
  • shakiness
  • slurred speech
  • stomachache
  • sweating
  • swelling of the fingers or hands
  • temporary blindness
  • tenderness on the upper right side of the body
  • trouble with breathing even at rest
  • unexplained weight loss
  • unusual bleeding or bruising
  • weakness in the arm and/or leg on one side of the body, sudden and severe
  • weakness or heaviness of the legs
  • yellow eyes or skin
Incidence not known:
  • Sores, ulcers, or white spots on the lips or in the mouth
  • swollen or painful glands
  • wheezing

Minor Side Effects

Some of the side effects that can occur with carvedilol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Back pain
  • diarrhea
  • prickling or tingling sensation
  • unusual tiredness or weakness
Less common:
  • Abdominal or stomach pain
  • bleeding gums
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • changes in vision
  • cold hands and feet
  • decreased interest in sexual intercourse
  • decreased tearing
  • difficulty with moving
  • feeling of constant movement of self or surroundings
  • general feeling of discomfort or illness
  • headache
  • inability to have or keep an erection
  • increased sweating
  • joint or muscle pain
  • lack or loss of strength
  • loose teeth
  • loss of sexual ability, desire, or performance
  • loss of strength or energy
  • muscle aches, stiffness, or weakness
  • nausea
  • persistent breath odor or bad taste in your mouth
  • redness and swelling of the gums
  • sensation of spinning
  • sleepiness or unusual drowsiness
  • sore throat
  • stuffy or runny nose
  • sugar in the urine
  • trouble sleeping
  • unusual weak feeling
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to carvedilol: oral capsule extended release, oral tablet


Common (1% to 10%): Weight increase, hypercholesterolemia, impaired blood glucose control (hyperglycemia, hypoglycemia) in patients with preexisting diabetes, gout, BUN increased, dehydration, hypervolemia[Ref]


Very common (10% or more): Chest pain (15%), hypotension, cardiac failure
Common (1% to 10%): Bradycardia, edema, hypervolemia, orthostatic hypotension, hypertension, syncope, disturbances of peripheral circulation (e.g., cold extremities, peripheral vascular disease, exacerbation of intermittent claudication, Raynaud's phenomenon)
Uncommon (0.1% to 1%): Atrioventricular block, angina pectoris, tachycardia
Rare (less than 0.1%): Complete AV block, bundle branch block, myocardial ischemia, cerebrovascular disorder[Ref]


Uncommon (0.1% to 1%): Allergic exanthema, dermatitis, urticaria, pruritus, psoriatic and lichen planus like skin lesions, increased sweating, alopecia, erythematous rash, maculopapular rash, photosensitivity reaction
Rare (less than 0.1%): Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme[Ref]


Common (1% to 10%): Nausea, diarrhea, vomiting, dyspepsia, abdominal pain, melena, periodontitis[Ref]


Common (1% to 10%): Urinary tract infection, micturition disorders, hematuria
Uncommon (0.1% to 1%): Erectile dysfunction
Postmarketing reports: Urinary incontinence in women[Ref]


The frequency of adverse reactions is not dose-dependent, with the exception of dizziness, abnormal vision and bradycardia.[Ref]


Common (1% to 10%): Anemia, purpura, prothrombin decrease
Rare (0.01% to 0.1%): Thrombocytopenia, aplastic anemia
Very rare (less than 0.01%): Leukopenia[Ref]


Very rare (less than 0.01%): Alanine aminotransferase (ALT) increased, aspartate aminotransferase (AST) increased, gamma-glutamyltransferase (GGT) increased[Ref]


Rare (less than 0.1%): Hypersensitivity reactions (including anaphylactic reactions, angioedema, and urticaria)[Ref]


Common (1% to 10%): Pain in extremities, back pain, arthralgia, myalgia[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, hyperesthesia, vertigo
Uncommon (0.1% to 1%): Presyncope, syncope, paresthesia,
Rare (0.01% to 0.1%): Convulsions, migraine, neuralgia, paresis, hypokinesia, neuralgia[Ref]


Common (1% to 10%): Visual impairment, abnormal vision, blurred vision, lacrimation decreased (dry eye), eye irritation[Ref]


Very common (10% or more): Fatigue (24%), asthenia
Common (1% to 10%): Pain, malaise, fever
Uncommon (0.1% to 1%): Tinnitus[Ref]


Common (1% to 10%): Depression, depressed mood, somnolence
Uncommon (0.1% to 1%): Sleep disorders, confusion, impaired concentration, abnormal thinking, paranoia, emotional lability, nervousness[Ref]


Common (1% to 10%): Renal failure and renal function abnormalities (in patients with diffuse vascular disease and/or underlying renal insufficiency), albuminuria[Ref]


Very common (10% or more): Upper respiratory tract infection (18%)
Common (1% to 10%): Bronchitis, pneumonia, dyspnea, pulmonary edema, asthma (in predisposed patients), sinusitis, pharyngitis, rhinitis, cough, rales[Ref]


1. "Product Information. Coreg (carvedilol)." SmithKline Beecham, Philadelphia, PA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for Coreg CR may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.