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Coreg CR Side Effects

Generic name: carvedilol

Medically reviewed by Last updated on Feb 8, 2023.

Note: This document contains side effect information about carvedilol. Some dosage forms listed on this page may not apply to the brand name Coreg CR.


Common side effects of Coreg CR include: hyperglycemia. Other side effects include: angina pectoris, hypotension, nausea, orthostatic hypotension, rales, visual disturbance, and vomiting. Continue reading for a comprehensive list of adverse effects.

Applies to carvedilol: oral capsules, oral tablets.

Side effects include:

Patients with heart failure receiving immediate-release carvedilol (the active ingredient contained in Coreg CR) tablets: Dizziness, headache, fatigue, asthenia, arthralgia, hypotension, bradycardia, generalized edema, diarrhea, nausea, vomiting, hyperglycemia, weight gain, increased BUN, increased nonprotein nitrogen (NPN), increased cough, abnormal vision.

Patients with left ventricular dysfunction following MI receiving immediate-release carvedilol tablets: Similar to those in patients receiving the drug for the treatment of heart failure. Anemia, dyspnea, pulmonary edema also reported.

Patients with hypertension receiving immediate-release carvedilol tablets: Dizziness, bradycardia, diarrhea, insomnia, postural hypotension.

Patients with hypertension receiving extended-release carvedilol phosphate capsules: Nasopharyngitis, dizziness, nausea, peripheral edema.

For Healthcare Professionals

Applies to carvedilol: oral capsule extended release, oral tablet.


Common (1% to 10%): Weight increase, hypercholesterolemia, impaired blood glucose control (hyperglycemia, hypoglycemia) in patients with preexisting diabetes, gout, BUN increased, dehydration, hypervolemia[Ref]


Very common (10% or more): Chest pain (15%), hypotension, cardiac failure

Common (1% to 10%): Bradycardia, edema, hypervolemia, orthostatic hypotension, hypertension, syncope, disturbances of peripheral circulation (e.g., cold extremities, peripheral vascular disease, exacerbation of intermittent claudication, Raynaud's phenomenon)

Uncommon (0.1% to 1%): Atrioventricular block, angina pectoris, tachycardia

Rare (less than 0.1%): Complete AV block, bundle branch block, myocardial ischemia, cerebrovascular disorder[Ref]


Uncommon (0.1% to 1%): Allergic exanthema, dermatitis, urticaria, pruritus, psoriatic and lichen planus like skin lesions, increased sweating, alopecia, erythematous rash, maculopapular rash, photosensitivity reaction

Rare (less than 0.1%): Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme[Ref]


Common (1% to 10%): Nausea, diarrhea, vomiting, dyspepsia, abdominal pain, melena, periodontitis[Ref]


Common (1% to 10%): Urinary tract infection, micturition disorders, hematuria

Uncommon (0.1% to 1%): Erectile dysfunction

Postmarketing reports: Urinary incontinence in women[Ref]


The frequency of adverse reactions is not dose-dependent, with the exception of dizziness, abnormal vision and bradycardia.[Ref]


Common (1% to 10%): Anemia, purpura, prothrombin decrease

Rare (0.01% to 0.1%): Thrombocytopenia, aplastic anemia

Very rare (less than 0.01%): Leukopenia[Ref]


Very rare (less than 0.01%): Alanine aminotransferase (ALT) increased, aspartate aminotransferase (AST) increased, gamma-glutamyltransferase (GGT) increased[Ref]


Rare (less than 0.1%): Hypersensitivity reactions (including anaphylactic reactions, angioedema, and urticaria)[Ref]


Common (1% to 10%): Pain in extremities, back pain, arthralgia, myalgia[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, hyperesthesia, vertigo

Uncommon (0.1% to 1%): Presyncope, syncope, paresthesia,

Rare (0.01% to 0.1%): Convulsions, migraine, neuralgia, paresis, hypokinesia, neuralgia[Ref]


Common (1% to 10%): Visual impairment, abnormal vision, blurred vision, lacrimation decreased (dry eye), eye irritation[Ref]


Very common (10% or more): Fatigue (24%), asthenia

Common (1% to 10%): Pain, malaise, fever

Uncommon (0.1% to 1%): Tinnitus[Ref]


Common (1% to 10%): Depression, depressed mood, somnolence

Uncommon (0.1% to 1%): Sleep disorders, confusion, impaired concentration, abnormal thinking, paranoia, emotional lability, nervousness[Ref]


Common (1% to 10%): Renal failure and renal function abnormalities (in patients with diffuse vascular disease and/or underlying renal insufficiency), albuminuria[Ref]


Very common (10% or more): Upper respiratory tract infection (18%)

Common (1% to 10%): Bronchitis, pneumonia, dyspnea, pulmonary edema, asthma (in predisposed patients), sinusitis, pharyngitis, rhinitis, cough, rales[Ref]


1. Product Information. Coreg (carvedilol). SmithKline Beecham. 2001.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.