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Colestipol Side Effects

For the Consumer

Applies to colestipol: oral powder for suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by colestipol. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking colestipol:

  • Black, tarry stools
  • stomach pain (severe) with nausea and vomiting

Severity: Moderate

If any of the following side effects occur while taking colestipol, check with your doctor or nurse as soon as possible:

More common:
  • Constipation
  • Loss of weight (sudden)

Minor Side Effects

Some of the side effects that can occur with colestipol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Belching
  • bloating
  • diarrhea
  • dizziness
  • headache
  • nausea or vomiting
  • stomach pain

For Healthcare Professionals

Applies to colestipol: oral granule for reconstitution, oral tablet


The most frequently reported side effects were gastrointestinal in nature and included constipation, abdominal pain, and abdominal discomfort.[Ref]


Very common (10% or more): Constipation, abdominal pain, abdominal discomfort
Common (1% to 10%): Hematochezia, hemorrhoid hemorrhage, abdominal distention, dyspepsia, nausea, vomiting, diarrhea, flatulence
Uncommon (0.1% to 1%): Belching, gastrointestinal bleeding, peptic ulcer, hemorrhoids
Frequency not reported: Indigestion[Ref]


Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Urticaria, dermatitis[Ref]

Nervous system

Very common (10% or more): Migraine, sinus headache, headache
Uncommon (0.1% to 1%): Dizziness
Rare (less than 0.1%): Drowsiness
Frequency not reported: Light-headedness


Uncommon (0.1% to 1%): Angina pectoris, tachycardia[Ref]


Common (1% to 10%): Fatigue
Uncommon (0.1% to 1%): Chest pain, peripheral edema, asthenia
Rare (less than 0.1%): Vertigo
Frequency not reported: Serum phosphorus increased, serum chloride increased, serum sodium decreased, serum potassium decreased, weakness[Ref]


Uncommon (0.1% to 1%): Cholecystitis, cholelithiasis, ALT increased, AST increased, blood alkaline phosphatase increased[Ref]


Common (1% to 10%): Arthritis, arthralgia, back pain, musculoskeletal pain, pain in extremity[Ref]


Uncommon (0.1% to 1%): Appetite decreased
Frequency not reported: Anorexia[Ref]


Uncommon (0.1% to 1%): Insomnia
Rare (less than 0.1%): Anxiety[Ref]


Uncommon (0.1% to 1%): Dyspnea
Frequency not reported: Shortness of breath[Ref]


1. "Product Information. Colestid (colestipol HCI)." Pharmacia and Upjohn, Kalamazoo, MI.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for colestipol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.