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Colestipol Side Effects

For the Consumer

Applies to colestipol: oral powder for suspension, oral tablet

Along with its needed effects, colestipol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking colestipol:


Check with your doctor as soon as possible if any of the following side effects occur while taking colestipol:

More common Rare
  • Loss of weight (sudden)

Some side effects of colestipol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to colestipol: oral granule for reconstitution, oral tablet


The most frequently reported side effects were gastrointestinal in nature and included constipation, abdominal pain, and abdominal discomfort.[Ref]


Very common (10% or more): Constipation, abdominal pain, abdominal discomfort
Common (1% to 10%): Hematochezia, hemorrhoid hemorrhage, abdominal distention, dyspepsia, nausea, vomiting, diarrhea, flatulence
Uncommon (0.1% to 1%): Belching, gastrointestinal bleeding, peptic ulcer, hemorrhoids
Frequency not reported: Indigestion[Ref]


Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Urticaria, dermatitis[Ref]

Nervous system

Very common (10% or more): Migraine, sinus headache, headache
Uncommon (0.1% to 1%): Dizziness
Rare (less than 0.1%): Drowsiness
Frequency not reported: Light-headedness


Uncommon (0.1% to 1%): Angina pectoris, tachycardia[Ref]


Common (1% to 10%): Fatigue
Uncommon (0.1% to 1%): Chest pain, peripheral edema, asthenia
Rare (less than 0.1%): Vertigo
Frequency not reported: Serum phosphorus increased, serum chloride increased, serum sodium decreased, serum potassium decreased, weakness[Ref]


Uncommon (0.1% to 1%): Cholecystitis, cholelithiasis, ALT increased, AST increased, blood alkaline phosphatase increased[Ref]


Common (1% to 10%): Arthritis, arthralgia, back pain, musculoskeletal pain, pain in extremity[Ref]


Uncommon (0.1% to 1%): Appetite decreased
Frequency not reported: Anorexia[Ref]


Uncommon (0.1% to 1%): Insomnia
Rare (less than 0.1%): Anxiety[Ref]


Uncommon (0.1% to 1%): Dyspnea
Frequency not reported: Shortness of breath[Ref]


1. "Product Information. Colestid (colestipol HCI)." Pharmacia and Upjohn, Kalamazoo, MI.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.