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Colestipol Side Effects

Medically reviewed by Last updated on Mar 16, 2024.

Applies to colestipol: oral powder for suspension, oral tablet.

Serious side effects of Colestipol

Along with its needed effects, colestipol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking colestipol:


Check with your doctor as soon as possible if any of the following side effects occur while taking colestipol:

More common


Other side effects of Colestipol

Some side effects of colestipol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to colestipol: oral granule for reconstitution, oral tablet.


The most frequently reported side effects were gastrointestinal in nature and included constipation, abdominal pain, and abdominal discomfort.[Ref]


Very common (10% or more): Constipation, abdominal pain, abdominal discomfort

Common (1% to 10%): Hematochezia, hemorrhoid hemorrhage, abdominal distention, dyspepsia, nausea, vomiting, diarrhea, flatulence

Uncommon (0.1% to 1%): Belching, gastrointestinal bleeding, peptic ulcer, hemorrhoids

Frequency not reported: Indigestion[Ref]


Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Urticaria, dermatitis[Ref]

Nervous system

Very common (10% or more): Migraine, sinus headache, headache

Uncommon (0.1% to 1%): Dizziness

Rare (less than 0.1%): Drowsiness

Frequency not reported: Light-headedness


Uncommon (0.1% to 1%): Angina pectoris, tachycardia[Ref]


Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Chest pain, peripheral edema, asthenia

Rare (less than 0.1%): Vertigo

Frequency not reported: Serum phosphorus increased, serum chloride increased, serum sodium decreased, serum potassium decreased, weakness[Ref]


Uncommon (0.1% to 1%): Cholecystitis, cholelithiasis, ALT increased, AST increased, blood alkaline phosphatase increased[Ref]


Common (1% to 10%): Arthritis, arthralgia, back pain, musculoskeletal pain, pain in extremity[Ref]


Uncommon (0.1% to 1%): Appetite decreased

Frequency not reported: Anorexia[Ref]


Uncommon (0.1% to 1%): Insomnia

Rare (less than 0.1%): Anxiety[Ref]


Uncommon (0.1% to 1%): Dyspnea

Frequency not reported: Shortness of breath[Ref]


1. "Product Information. Colestid (colestipol)." Pharmacia and Upjohn

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.