Bystolic Side Effects
Generic name: nebivolol
Medically reviewed by Drugs.com. Last updated on Jan 18, 2023.
Note: This document contains side effect information about nebivolol. Some dosage forms listed on this page may not apply to the brand name Bystolic.
Summary
More frequent side effects include: fatigue. Continue reading for a comprehensive list of adverse effects.
Applies to nebivolol: oral tablets.
Side effects include:
Headache, fatigue, dizziness, diarrhea, nausea.
For Healthcare Professionals
Applies to nebivolol: oral tablet.
General
The more frequently reported side effects in patients treated for hypertension were headache, dizziness, and fatigue; additionally, bradycardia was frequently reported in patients treated for chronic heart failure.[Ref]
Cardiovascular
Very common (10% or more): Bradycardia (up to 11%)
Common (1% to 10%): Cardiac failure aggravation, edema, postural hypotension, first degree atrioventricular (AV) block, atrial fibrillation, hypertension, angina pectoris, chest pain
Uncommon (0.1% to 1%): Heart failure, slowed AV conduction, AV block (both second and third degree), hypotension, increased intermittent claudication, edema of the lower limbs,
Postmarketing reports: Raynaud's phenomenon, myocardial infarction, peripheral ischemia[Ref]
Bradycardia was a dose-related effect in hypertensive patients. Bradycardia occurred more frequently in chronic heart failure patients (11%) than hypertensive patients (1%) at doses of 20 to 40 mg.
Aggravation of cardiac failure occurred in 19% of patients with chronic heart failure compared to 21.3% of placebo-treated patients in the SENIORS (Study on the Effects of Nebivolol Interventions on Outcomes and Rehospitalizations in Seniors with heart failure; n = 2128; median age = 75.2 years). Heart failure occurred in 0.1% to 1% of hypertensive patients.[Ref]
Nervous system
Very common (10% or more): Dizziness (up to 11%)
Common (1% to 10%): Headache, paresthesia, somnolence, hypoesthesia
Uncommon (0.1% to 1%): Vertigo
Very rare (less than 0.01%): Syncope[Ref]
Respiratory
Common (1% to 10%): Dyspnea, exacerbated dyspnea, common cold, coughing, bronchitis, pharyngitis
Uncommon (0.1% to 1%): Bronchospasm
Postmarketing reports: Acute pulmonary edema[Ref]
Dermatologic
Common (1% to 10%): Increased sweating
Uncommon (0.1% to 1%): Pruritus, erythematous rash
Very rare (less than 0.01%): Psoriasis aggravated
Frequency not reported: Angioneurotic edema, urticaria
Postmarketing reports: Rash, skin disorders[Ref]
Musculoskeletal
Common (1% to 10%): Myalgia, arthrosis, back pain[Ref]
Gastrointestinal
Common (1% to 10%): Constipation, diarrhea, nausea
Uncommon (0.1% to 1%): Dyspepsia, flatulence, vomiting
Frequency not reported: Abdominal pain[Ref]
Other
Common (1% to 10%): Tiredness, drug intolerance, pain, injury, fatigue
Frequency not reported: Asthenia[Ref]
Psychiatric
Common (1% to 10%): Nervousness
Uncommon (0.1% to 1%): Nightmares, depression, insomnia, anxiety[Ref]
Genitourinary
Uncommon (0.1% to 1%): Impotence[Ref]
Ocular
Uncommon (0.1% to 1%): Impaired vision[Ref]
Hematologic
Frequency not reported: Decreased platelet count
Postmarketing reports: Thrombocytopenia[Ref]
Renal
Frequency not reported: Increased BUN
Postmarketing reports: Acute renal failure[Ref]
Metabolic
Frequency not reported: Hypercholesterolemia, hyperuricemia, increased uric acid, increased triglycerides, decreased HDL cholesterol[Ref]
Hepatic
Postmarketing reports: Abnormal hepatic function (e.g., increased AST, ALT, and bilirubin)[Ref]
Hypersensitivity
Postmarketing reports: Hypersensitivity (e.g., allergic vasculitis, angioedema, urticaria)[Ref]
More about Bystolic (nebivolol)
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References
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Bystolic (nebivolol)." Forest Pharmaceuticals (2007):
3. Cerner Multum, Inc. "Australian Product Information." O 0
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.