Bystolic Side Effects

Generic name: nebivolol

Medically reviewed by Drugs.com. Last updated on Jan 18, 2023.

Note: This document contains side effect information about nebivolol. Some dosage forms listed on this page may not apply to the brand name Bystolic.

Summary

More frequent side effects include: fatigue. Continue reading for a comprehensive list of adverse effects.

Applies to nebivolol: oral tablets.

Side effects include:

Headache, fatigue, dizziness, diarrhea, nausea.

For Healthcare Professionals

Applies to nebivolol: oral tablet.

General

The more frequently reported side effects in patients treated for hypertension were headache, dizziness, and fatigue; additionally, bradycardia was frequently reported in patients treated for chronic heart failure.^[Ref]

Cardiovascular

Very common (10% or more): Bradycardia (up to 11%)

Common (1% to 10%): Cardiac failure aggravation, edema, postural hypotension, first degree atrioventricular (AV) block, atrial fibrillation, hypertension, angina pectoris, chest pain

Uncommon (0.1% to 1%): Heart failure, slowed AV conduction, AV block (both second and third degree), hypotension, increased intermittent claudication, edema of the lower limbs,

Postmarketing reports: Raynaud's phenomenon, myocardial infarction, peripheral ischemia^[Ref]

Bradycardia was a dose-related effect in hypertensive patients. Bradycardia occurred more frequently in chronic heart failure patients (11%) than hypertensive patients (1%) at doses of 20 to 40 mg.

Aggravation of cardiac failure occurred in 19% of patients with chronic heart failure compared to 21.3% of placebo-treated patients in the SENIORS (Study on the Effects of Nebivolol Interventions on Outcomes and Rehospitalizations in Seniors with heart failure; n = 2128; median age = 75.2 years). Heart failure occurred in 0.1% to 1% of hypertensive patients.^[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 11%)

Common (1% to 10%): Headache, paresthesia, somnolence, hypoesthesia

Uncommon (0.1% to 1%): Vertigo

Very rare (less than 0.01%): Syncope^[Ref]

Respiratory

Common (1% to 10%): Dyspnea, exacerbated dyspnea, common cold, coughing, bronchitis, pharyngitis

Uncommon (0.1% to 1%): Bronchospasm

Postmarketing reports: Acute pulmonary edema^[Ref]

Dermatologic

Common (1% to 10%): Increased sweating

Uncommon (0.1% to 1%): Pruritus, erythematous rash

Very rare (less than 0.01%): Psoriasis aggravated

Frequency not reported: Angioneurotic edema, urticaria

Postmarketing reports: Rash, skin disorders^[Ref]

Musculoskeletal

Common (1% to 10%): Myalgia, arthrosis, back pain^[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, diarrhea, nausea

Uncommon (0.1% to 1%): Dyspepsia, flatulence, vomiting

Frequency not reported: Abdominal pain^[Ref]

Other

Common (1% to 10%): Tiredness, drug intolerance, pain, injury, fatigue

Frequency not reported: Asthenia^[Ref]

Psychiatric

Common (1% to 10%): Nervousness

Uncommon (0.1% to 1%): Nightmares, depression, insomnia, anxiety^[Ref]

Genitourinary

Uncommon (0.1% to 1%): Impotence^[Ref]

Ocular

Uncommon (0.1% to 1%): Impaired vision^[Ref]

Hematologic

Frequency not reported: Decreased platelet count

Postmarketing reports: Thrombocytopenia^[Ref]

Renal

Frequency not reported: Increased BUN

Postmarketing reports: Acute renal failure^[Ref]

Metabolic

Frequency not reported: Hypercholesterolemia, hyperuricemia, increased uric acid, increased triglycerides, decreased HDL cholesterol^[Ref]

Hepatic

Postmarketing reports: Abnormal hepatic function (e.g., increased AST, ALT, and bilirubin)^[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity (e.g., allergic vasculitis, angioedema, urticaria)^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer