Bystolic Side Effects

Generic name: nebivolol

Medically reviewed by Drugs.com. Last updated on Jan 18, 2024.

Note: This document provides detailed information about Bystolic Side Effects associated with nebivolol. Some dosage forms listed on this page may not apply specifically to the brand name Bystolic.

Applies to nebivolol: oral tablet.

Common side effects of Bystolic

Some side effects of nebivolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• mild headache

Less common side effects

• diarrhea
• rash
• sleeplessness
• trouble sleeping
• unable to sleep

Serious side effects of Bystolic

Along with its needed effects, nebivolol (the active ingredient contained in Bystolic) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nebivolol:

Less common side effects

• bloating or swelling of the face, arms, hands, lower legs, or feet
• chest pain or discomfort
• difficult or labored breathing
• lightheadedness, dizziness, or fainting
• rapid weight gain
• shortness of breath
• slow or irregular heartbeat
• tightness in the chest
• tingling of the hands or feet
• unusual tiredness or weakness
• unusual weight gain or loss
• wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking nebivolol:

Symptoms of overdose

• absence of or decrease in body movement
• anxiety
• blue lips, fingernails, or skin
• blurred vision
• chills
• cold sweats
• coma
• confusion
• cool, pale skin
• cough
• decreased urine output
• depression
• dilated neck veins
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• extreme fatigue
• fast heartbeat
• headache
• increased hunger
• increased sweating
• increased thirst
• irregular, fast or slow, or shallow breathing
• loss of appetite
• mood changes
• muscle pain or cramps
• nausea or vomiting
• nervousness
• nightmares
• noisy breathing
• numbness in the hands, feet, or lips
• seizures
• shakiness
• slurred speech
• troubled breathing
• vomiting
• weight gain

For healthcare professionals

Applies to nebivolol: oral tablet.

General adverse events

The more frequently reported side effects in patients treated for hypertension were headache, dizziness, and fatigue; additionally, bradycardia was frequently reported in patients treated for chronic heart failure.^[Ref]

Cardiovascular

• Very common (10% or more): Bradycardia (up to 11%)
• Common (1% to 10%): Cardiac failure aggravation, edema, postural hypotension, first degree atrioventricular (AV) block, atrial fibrillation, hypertension, angina pectoris, chest pain
• Uncommon (0.1% to 1%): Heart failure, slowed AV conduction, AV block (both second and third degree), hypotension, increased intermittent claudication, edema of the lower limbs,
• Postmarketing reports: Raynaud's phenomenon, myocardial infarction, peripheral ischemia^[Ref]

Bradycardia was a dose-related effect in hypertensive patients. Bradycardia occurred more frequently in chronic heart failure patients (11%) than hypertensive patients (1%) at doses of 20 to 40 mg.

Aggravation of cardiac failure occurred in 19% of patients with chronic heart failure compared to 21.3% of placebo-treated patients in the SENIORS (Study on the Effects of Nebivolol (the active ingredient contained in Bystolic) Interventions on Outcomes and Rehospitalizations in Seniors with heart failure; n = 2128; median age = 75.2 years). Heart failure occurred in 0.1% to 1% of hypertensive patients.^[Ref]

Nervous system

• Very common (10% or more): Dizziness (up to 11%)
• Common (1% to 10%): Headache, paresthesia, somnolence, hypoesthesia
• Uncommon (0.1% to 1%): Vertigo
• Very rare (less than 0.01%): Syncope^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea, exacerbated dyspnea, common cold, coughing, bronchitis, pharyngitis
• Uncommon (0.1% to 1%): Bronchospasm
• Postmarketing reports: Acute pulmonary edema^[Ref]

Dermatologic

• Common (1% to 10%): Increased sweating
• Uncommon (0.1% to 1%): Pruritus, erythematous rash
• Very rare (less than 0.01%): Psoriasis aggravated
• Frequency not reported: Angioneurotic edema, urticaria
• Postmarketing reports: Rash, skin disorders^[Ref]

Musculoskeletal

• Common (1% to 10%): Myalgia, arthrosis, back pain^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, diarrhea, nausea
• Uncommon (0.1% to 1%): Dyspepsia, flatulence, vomiting
• Frequency not reported: Abdominal pain^[Ref]

Other

• Common (1% to 10%): Tiredness, drug intolerance, pain, injury, fatigue
• Frequency not reported: Asthenia^[Ref]

Psychiatric

• Common (1% to 10%): Nervousness
• Uncommon (0.1% to 1%): Nightmares, depression, insomnia, anxiety^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Impotence^[Ref]

Ocular

• Uncommon (0.1% to 1%): Impaired vision^[Ref]

Hematologic

• Frequency not reported: Decreased platelet count
• Postmarketing reports: Thrombocytopenia^[Ref]

Renal

• Frequency not reported: Increased BUN
• Postmarketing reports: Acute renal failure^[Ref]

Metabolic

• Frequency not reported: Hypercholesterolemia, hyperuricemia, increased uric acid, increased triglycerides, decreased HDL cholesterol^[Ref]

Hepatic

• Postmarketing reports: Abnormal hepatic function (e.g., increased AST, ALT, and bilirubin)^[Ref]

Hypersensitivity

• Postmarketing reports: Hypersensitivity (e.g., allergic vasculitis, angioedema, urticaria)^[Ref]

Further information

Bystolic side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer