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Brinzolamide ophthalmic Side Effects

In Summary

More frequently reported side effects include: blurred vision, bitter taste, dysgeusia, and sour taste. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to brinzolamide ophthalmic: ophthalmic suspension

Along with its needed effects, brinzolamide ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brinzolamide ophthalmic:

More common
  • Blurred vision
Less common
  • Discharge from the eye
  • dry eyes
  • redness, soreness, irritation, or pain of the eye or eyelid
  • skin rash
Rare
  • Chest pain
  • cough
  • crusting in the corner of the eye
  • difficulty with swallowing
  • dizziness
  • double vision
  • excessive muscle tone
  • eye redness, irritation, or pain
  • fast heartbeat
  • hives
  • itching, swelling, or other signs of eye or eyelid irritation
  • kidney pain
  • muscle stiffness
  • muscle tension or tightness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seeing double
  • shortness of breath
  • sore throat
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
Incidence not known
  • Abdominal or stomach pain
  • blistering, peeling, or loosening of the skin
  • chills
  • clay-colored stools
  • dark urine
  • diarrhea
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • hoarseness
  • joint or muscle pain
  • loss of appetite
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • red or irritated eyes
  • red skin lesions, often with a purple center
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen or painful glands
  • unpleasant breath odor
  • unusual bleeding or bruising
  • vomiting of blood
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking brinzolamide ophthalmic:

Symptoms of overdose
  • Confusion
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • seizures
  • trembling
  • weakness and heaviness of the legs

Some side effects of brinzolamide ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bitter, sour, or other unusual taste
Less common
  • Burning, stinging, or discomfort when medicine is applied
  • dry eyes
  • feeling of something in the eye
  • runny nose
  • sneezing
  • stuffy nose
Rare
  • Acid or sour stomach
  • belching
  • body aches or pain
  • congestion
  • difficult or labored breathing
  • dry mouth
  • hair loss
  • heartburn
  • hives or welts
  • indigestion
  • stomach discomfort, upset, or pain
  • tender, swollen glands in the neck
  • thinning of the hair
  • voice changes

For Healthcare Professionals

Applies to brinzolamide ophthalmic: ophthalmic suspension

Ocular

Common (1% to 10%): Blepharitis, dry eye, foreign body sensation, ocular hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus, blurred vision, eye irritation
Uncommon (0.1% to 1%): Conjunctivitis, diplopia, eye fatigue, keratoconjunctivitis, lid margin crusting or sticky sensation, tearing, corneal erosion, punctate keratitis, keratopathy, corneal staining, corneal epithelium defect, corneal epithelium disorder, increased intraocular pressure, increased optic nerve cup/disc ratio, corneal edema, eye swelling, meibomianitis, glare, photophobia, photopsia, reduced visual acuity, allergic conjunctivitis, pterygium, scleral pigmentation, asthenopia, keratoconjunctivitis sicca, eye hypoesthesia, subconjunctival cyst, conjunctival hyperemia, eyelids pruritus
Frequency not reported: Corneal disorder, visual disturbance, eye allergy, madarosis, eyelid disorder, eyelid erythema[Ref]

Hypersensitivity

Common (1% to 10%): Allergic reactions
Frequency not reported: Hypersensitivity[Ref]

Other

Uncommon (0.1% to 1%): Pain, asthenia, fatigue, feeling abnormal, feeling jittery
Frequency not reported: Peripheral edema, malaise, medication residue[Ref]

Nervous system

Common (1% to 10%): Headache, dysgeusia, tinnitus
Uncommon (0.1% to 1%): Dizziness, hypertonia, somnolence, motor dysfunction, amnesia, memory impairment, paresthesia
Frequency not reported: Tremor, hypoesthesia, ageusia, vertigo[Ref]

Dermatologic

Common (1% to 10%): Dermatitis
Uncommon (0.1% to 1%): Alopecia, urticaria, rash, maculo-papular rash, generalized pruritus, skin tightness[Ref]

Gastrointestinal

Uncommon (0.1% to 1%): Diarrhea, dry mouth, dyspepsia, nausea, esophagitis, vomiting, upper abdominal pain, abdominal discomfort, stomach discomfort, flatulence, frequent bowel movements, gastrointestinal disorder, oral hypoesthesia, oral paresthesia[Ref]

Respiratory

Common (1% to 10%): Rhinitis
Uncommon (0.1% to 1%): Dyspnea, pharyngitis, nasopharyngitis, sinusitis, bronchial hyperactivity, cough, epistaxis, pharyngolaryngeal pain, throat irritation, nasal congestion, upper respiratory tract congestion, postnasal drip, rhinorrhea, sneezing, nasal dryness
Frequency not reported: Asthma[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Cardio-respiratory distress, angina pectoris, bradycardia, irregular palpitations
Frequency not reported: Arrhythmia, tachycardia, hypertension, increased blood pressure, increased heart rate[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Back pain, muscle spasms, myalgia
Frequency not reported: Arthralgia, pain in extremity[Ref]

Renal

Uncommon (0.1% to 1%): Kidney pain
Frequency not reported: Pollakiuria[Ref]

General

The most commonly reported adverse reactions were blurred vision and bitter, sour or unusual taste.[Ref]

Genitourinary

Uncommon (0.1% to 1%): Decreased libido, erectile dysfunction[Ref]

Hematologic

Uncommon (0.1% to 1%): Decreased red blood cell count, increased blood chloride[Ref]

Hepatic

Frequency not reported: Abnormal liver function test[Ref]

Psychiatric

Uncommon (0.1% to 1%): Apathy, depression, depressed mood, nightmare, insomnia, nervousness, irritability[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Azopt (brinzolamide ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.

3. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of brinzolamide ophthalmic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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