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Brevibloc Side Effects

Generic name: esmolol

Medically reviewed by Last updated on Sep 14, 2023.

Note: This document contains side effect information about esmolol. Some dosage forms listed on this page may not apply to the brand name Brevibloc.

Applies to esmolol: intravenous solution.

Serious side effects of Brevibloc

Along with its needed effects, esmolol (the active ingredient contained in Brevibloc) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking esmolol:

More common

Less common


Get emergency help immediately if any of the following symptoms of overdose occur while taking esmolol:

Symptoms of overdose

Other side effects of Brevibloc

Some side effects of esmolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to esmolol: intravenous solution.


Very common (10% or more): Hypotension

Uncommon (0.1% to 1%): Bradycardia, atrioventricular block, pulmonary arterial pressure increased, cardiac failure, ventricular extrasystoles, nodal rhythm, angina pectoris, peripheral ischemia, pallor, flushing, chest pain, asystole

Rare (0.01% to 0.1%): Sinus pause

Very rare (less than 0.01%): Sinus arrest, asystole, thrombophlebitis

Frequency not reported: Accelerated idioventricular rhythm, coronary arteriospasm, cardiac arrest[Ref]


Very common (10% or more): Diaphoresis

Uncommon (0.1% to 1%): Skin discoloration, erythema

Very rare (less than 0.01%): Skin necrosis (due to extravasation)

Frequency not reported: Psoriasis, angioedema, urticaria[Ref]


Common (1% to 10%): Nausea, vomiting

Uncommon (0.1% to 1%): Dysgeusia, dyspepsia, constipation, dry mouth, abdominal pain[Ref]


Uncommon (0.1% to 1%): Urinary retention[Ref]


Common (1% to 10%): Injection site reaction, infusion site reaction, infusion site inflammation, infusion site induration

Uncommon (0.1% to 1%): Infusion site burning, infusion site ecchymosis

Frequency not reported: Infusion site phlebitis, infusion site vesicles, blistering[Ref]

Nervous system

Common (1% to 10%): Dizziness, somnolence, headache, paresthesia, weakness

Uncommon (0.1% to 1%): Syncope, convulsion, speech disorder, light headedness[Ref]


Frequency not reported: Hyperkalemia, metabolic acidosis[Ref]


Uncommon (0.1% to 1%): Musculoskeletal pain[Ref]


Uncommon (0.1% to 1%): Visual impairment[Ref]


Common (1% to 10%): Asthenia, fatigue

Uncommon (0.1% to 1%): Chills, pyrexia, edema, pain[Ref]


Common (1% to 10%): Depression, anxiety, disturbance in attention, confusion, agitation

Uncommon (less than 1%): Abnormal thinking[Ref]


Uncommon (less than 1%): Dyspnea, pulmonary edema, bronchospasm, wheezing, nasal congestion, rhonchi, rales[Ref]


1. (2001) "Product Information. Brevibloc (esmolol)." DuPont Pharmaceuticals

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.