Azor Side Effects

Generic name: amlodipine / olmesartan

Medically reviewed by Drugs.com. Last updated on Apr 28, 2024.

Note: This document provides detailed information about Azor Side Effects associated with amlodipine / olmesartan. Some dosage forms listed on this page may not apply specifically to the brand name Azor.

Applies to amlodipine / olmesartan: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby, especially in your second or third trimester. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. You may need to stop using this medicine and change to another blood pressure medicine.

Dizziness, lightheadedness, or fainting may also occur especially when you get up from a lying or sitting position or if you have been taking a diuretic (water pill). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water and may lead to blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

Check with your doctor right away if you have chest pain that is worse than usual, trouble breathing, nausea, unusual sweating, faintness, or pain in your arms, jaw, back, or neck. This medicine may worsen the symptoms of an existing heart problem.

Severe, chronic diarrhea with weight loss may develop months to years after taking this medicine. Tell your doctor right away if you have these symptoms.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Azor

Along with its needed effects, amlodipine / olmesartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / olmesartan:

Other side effects of Azor

Some side effects of amlodipine / olmesartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to amlodipine / olmesartan: oral tablet.

General adverse events

The most common adverse reaction is edema.^[Ref]

Other

• Very common (10% or more): Edema (up to 13.3%)
• Common (1% to 10%): Fatigue, peripheral edema, pitting edema
• Uncommon (0.1% to 1%): Asthenia
• Rare (less than 0.1%): Face edema

Amlodipine:

• Very common (10% or more): Edema (up to 24.5%)
• Common (1% to 10%): Fatigue, peripheral edema
• Uncommon (0.1% to 1%): Asthenia, chest pain, malaise, pain, pitting edema, gynecomastia

Olmesartan:

• Common (1% to 10%): Chest pain, fatigue, influenza-like symptoms, pain, peripheral edema, edema
• Uncommon (0.1% to 1%): Asthenia, face edema, malaise, pitting edema^[Ref]

There was a greater incidence of edema in women (14.6%) than men (5.6%).^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache
• Uncommon (0.1% to 1%): Hypoesthesia, lethargy, paresthesia, postural dizziness, vertigo
• Rare (less than 0.1%): Syncope

Amlodipine:

• Common (1% to 10%): Dizziness, headache, somnolence
• Uncommon (0.1% to 1%): Dysgeusia, hypoesthesia, paresthesia, syncope, tremor, tinnitus, postural dizziness, vertigo, peripheral neuropathy
• Very rare (less than 0.01%): Hypertonia
• Frequency not reported: Extrapyramidal syndrome, ataxia, migraine, amnesia, parosmia

Olmesartan:

• Common (1% to 10%): Dizziness, headache
• Uncommon (0.1% to 1%): Vertigo
• Rare (less than 0.1%): Lethargy^[Ref]

There was a greater incidence of somnolence in women (1.6%) than men (1.3%).^[Ref]

Gastrointestinal

• Uncommon (0.1% to 1%): Constipation, diarrhea, dry mouth, dyspepsia, nausea, upper abdominal pain, vomiting

Amlodipine:

• Common (1% to 10%): Abdominal pain, nausea
• Uncommon (0.1% to 1%): Altered bowel habits, dry mouth, dyspepsia, vomiting, constipation, dysphagia, diarrhea, flatulence, pancreatitis, gingival hyperplasia
• Very rare (less than 0.01%): Gastritis
• Frequency not reported: Loose stools

Olmesartan:

• Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, gastroenteritis, nausea
• Uncommon (0.1% to 1%): Vomiting
• Very rare (less than 0.01%): Sprue-like enteropathy^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Palpitations, tachycardia, hypotension, orthostatic hypotension, hypertension
• Rare (less than 0.1%): Flushing

Amlodipine:

• Common (1% to 10%): Flushing, palpitation
• Uncommon (0.1% to 1%): Angina pectoris, hypotension, peripheral ischemia, tachycardia, postural hypotension, hot flushes, vasculitis
• Very rare (less than 0.01%): Arrhythmia, myocardial infarction
• Frequency not reported: Cardiac failure, pulse irregularity, extrasystoles

Olmesartan:

• Uncommon (0.1% to 1%): Angina pectoris, hypertension, tachycardia
• Rare (less than 0.1%): Hypotension^[Ref]

There was a greater incidence of flushing and palpitation in women than men. The incidence of flushing was 4.5% in females and 1.5% in males. The incidence of palpitation was 3.3% in females and 1.4% in males.^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Back pain, muscle spasm, pain in extremity

Amlodipine:

• Common (1% to 10%): Ankle swelling
• Uncommon (0.1% to 1%): Arthralgia, back pain, muscle spasm, myalgia, rigors, arthrosis, muscle cramps
• Frequency not reported: Muscle weakness, twitching

Olmesartan:

• Common (1% to 10%): Arthritis, back pain, skeletal pain, blood creatine phosphokinase increased
• Uncommon (0.1% to 1%): Myalgia, arthralgia
• Rare (less than 0.1%): Muscle spasm
• Frequency not reported: Rhabdomyolysis^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Pollakiuria, erectile dysfunction/impotence

Amlodipine:

• Uncommon (0.1% to 1%): Increased urinary frequency, micturition disorder, nocturia, erectile dysfunction/impotence, gynecomastia, sexual dysfunction
• Frequency not reported: Dysuria, polyuria

Olmesartan:

• Common (1% to 10%): Hematuria, urinary tract infection^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Hyperkalemia, blood potassium decreased

Amlodipine:

• Uncommon (0.1% to 1%): Weight decreased, weight increased, anorexia, thirst, hyperglycemia
• Frequency not reported: Increased appetite

Olmesartan:

• Common (1% to 10%): Hypertriglyceridemia, hyperuricemia, hyperglycemia
• Rare (less than 0.1%): Hyperkalemia^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Cough, dyspnea

Amlodipine:

• Uncommon (0.1% to 1%): Dyspnea, rhinitis, epistaxis
• Very rare (less than 0.01%): Cough

Olmesartan:

• Common (1% to 10%): Bronchitis, cough, pharyngitis, rhinitis, sinusitis^[Ref]

Renal

• Uncommon (0.1% to 1%): Blood creatinine increased, blood uric acid increased

Olmesartan:

• Common (1% to 10%): Blood urea increased
• Rare (less than 0.1%): Acute renal failure, renal insufficiency, blood creatinine increased^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash
• Rare (less than 0.1%): Urticaria

Amlodipine:

• Uncommon (0.1% to 1%): Alopecia, exanthema, hyperhidrosis, pruritus, purpura, rash, skin discoloration, sweating increased, angioedema, rash erythematous, rash maculopapular
• Very rare (less than 0.01%): Angioneurotic edema, erythema multiforme, exfoliative dermatitis, photosensitivity, Quincke edema, Stevens-Johnson syndrome, urticaria
• Frequency not reported: Skin dryness, dermatitis, cold and clammy skin

Olmesartan:

• Uncommon (0.1% to 1%): Allergic dermatitis, exanthema, pruritus, rash, urticaria
• Rare (less than 0.1%): Angioneurotic edema
• Postmarketing reports: Angioedema, alopecia^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Libido decreased

Amlodipine:

• Uncommon (0.1% to 1%): Depression, insomnia, irritability, mood changes, sleep disorder, nervousness, abnormal dreams, anxiety, depersonalization
• Rare (less than 0.1%): Confusion
• Frequency not reported: Apathy, agitation^[Ref]

Hepatic

• Uncommon (0.1% to 1%): GGT increased

Amlodipine:

• Very rare (less than 0.01%): Hepatic enzymes increased, hepatitis, jaundice

Olmesartan:

• Common (1% to 10%): Hepatic enzymes increased^[Ref]

Immunologic

• Rare (less than 0.1%): Allergic reaction/drug hypersensitivity

Amlodipine:

• Uncommon (0.1% to 1%): Allergic reactions
• Very rare (less than 0.01%): Allergic reaction/drug hypersensitivity

Olmesartan:

• Uncommon (0.1% to 1%): Anaphylactic reaction^[Ref]

Ocular

Amlodipine:

• Uncommon (0.1% to 1%): Visual disturbance, abnormal vision, conjunctivitis, diplopia, eye pain
• Frequency not reported: Xerophthalmia^[Ref]

Hematologic

• Frequency not reported: Hemoglobin decreased, hematocrit decreased

Amlodipine:

• Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia

Olmesartan:

• Uncommon (0.1% to 1%): Thrombocytopenia^[Ref]

See also:

Further information

Azor side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer