Azor Side Effects

Generic name: amlodipine / olmesartan

Medically reviewed by Drugs.com. Last updated on Apr 28, 2024.

Note: This document provides detailed information about Azor Side Effects associated with amlodipine / olmesartan. Some dosage forms listed on this page may not apply specifically to the brand name Azor.

Applies to amlodipine / olmesartan: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Drugs with direct action on the renin-angiotensin system can cause injury or death to the developing fetus when used during pregnancy.

Stop therapy as soon as possible if pregnancy occurs.

Serious side effects of Azor

Along with its needed effects, amlodipine / olmesartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / olmesartan:

More common side effects

• bloating or swelling of the face, arms, hands, lower legs, or feet
• rapid weight gain

Less common side effects

• fast, irregular, pounding, or racing heartbeat or pulse
• unusual tiredness or weakness

Incidence not known

• dark urine
• decreased urine output
• diarrhea
• fever
• itching, skin rash
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• light-colored stools
• muscle pain or stiffness
• stomach pain
• upper right abdominal or stomach pain
• yellow eyes or skin

Other side effects of Azor

Some side effects of amlodipine / olmesartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• dizziness
• feeling of warmth
• redness of the face, neck, arms, and occasionally, upper chest
• sleepiness or unusual drowsiness

Incidence not known

• hives or welts
• redness of the skin

For healthcare professionals

Applies to amlodipine / olmesartan: oral tablet.

General adverse events

The most common adverse reaction is edema.^[Ref]

Other

• Very common (10% or more): Edema (up to 13.3%)
• Common (1% to 10%): Fatigue, peripheral edema, pitting edema
• Uncommon (0.1% to 1%): Asthenia
• Rare (less than 0.1%): Face edema

Amlodipine:

• Very common (10% or more): Edema (up to 24.5%)
• Common (1% to 10%): Fatigue, peripheral edema
• Uncommon (0.1% to 1%): Asthenia, chest pain, malaise, pain, pitting edema, gynecomastia

Olmesartan:

• Common (1% to 10%): Chest pain, fatigue, influenza-like symptoms, pain, peripheral edema, edema
• Uncommon (0.1% to 1%): Asthenia, face edema, malaise, pitting edema^[Ref]

There was a greater incidence of edema in women (14.6%) than men (5.6%).^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache
• Uncommon (0.1% to 1%): Hypoesthesia, lethargy, paresthesia, postural dizziness, vertigo
• Rare (less than 0.1%): Syncope

Amlodipine:

• Common (1% to 10%): Dizziness, headache, somnolence
• Uncommon (0.1% to 1%): Dysgeusia, hypoesthesia, paresthesia, syncope, tremor, tinnitus, postural dizziness, vertigo, peripheral neuropathy
• Very rare (less than 0.01%): Hypertonia
• Frequency not reported: Extrapyramidal syndrome, ataxia, migraine, amnesia, parosmia

Olmesartan:

• Common (1% to 10%): Dizziness, headache
• Uncommon (0.1% to 1%): Vertigo
• Rare (less than 0.1%): Lethargy^[Ref]

There was a greater incidence of somnolence in women (1.6%) than men (1.3%).^[Ref]

Gastrointestinal

• Uncommon (0.1% to 1%): Constipation, diarrhea, dry mouth, dyspepsia, nausea, upper abdominal pain, vomiting

Amlodipine:

• Common (1% to 10%): Abdominal pain, nausea
• Uncommon (0.1% to 1%): Altered bowel habits, dry mouth, dyspepsia, vomiting, constipation, dysphagia, diarrhea, flatulence, pancreatitis, gingival hyperplasia
• Very rare (less than 0.01%): Gastritis
• Frequency not reported: Loose stools

Olmesartan:

• Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, gastroenteritis, nausea
• Uncommon (0.1% to 1%): Vomiting
• Very rare (less than 0.01%): Sprue-like enteropathy^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Palpitations, tachycardia, hypotension, orthostatic hypotension, hypertension
• Rare (less than 0.1%): Flushing

Amlodipine:

• Common (1% to 10%): Flushing, palpitation
• Uncommon (0.1% to 1%): Angina pectoris, hypotension, peripheral ischemia, tachycardia, postural hypotension, hot flushes, vasculitis
• Very rare (less than 0.01%): Arrhythmia, myocardial infarction
• Frequency not reported: Cardiac failure, pulse irregularity, extrasystoles

Olmesartan:

• Uncommon (0.1% to 1%): Angina pectoris, hypertension, tachycardia
• Rare (less than 0.1%): Hypotension^[Ref]

There was a greater incidence of flushing and palpitation in women than men. The incidence of flushing was 4.5% in females and 1.5% in males. The incidence of palpitation was 3.3% in females and 1.4% in males.^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Back pain, muscle spasm, pain in extremity

Amlodipine:

• Common (1% to 10%): Ankle swelling
• Uncommon (0.1% to 1%): Arthralgia, back pain, muscle spasm, myalgia, rigors, arthrosis, muscle cramps
• Frequency not reported: Muscle weakness, twitching

Olmesartan:

• Common (1% to 10%): Arthritis, back pain, skeletal pain, blood creatine phosphokinase increased
• Uncommon (0.1% to 1%): Myalgia, arthralgia
• Rare (less than 0.1%): Muscle spasm
• Frequency not reported: Rhabdomyolysis^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Pollakiuria, erectile dysfunction/impotence

Amlodipine:

• Uncommon (0.1% to 1%): Increased urinary frequency, micturition disorder, nocturia, erectile dysfunction/impotence, gynecomastia, sexual dysfunction
• Frequency not reported: Dysuria, polyuria

Olmesartan:

• Common (1% to 10%): Hematuria, urinary tract infection^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Hyperkalemia, blood potassium decreased

Amlodipine:

• Uncommon (0.1% to 1%): Weight decreased, weight increased, anorexia, thirst, hyperglycemia
• Frequency not reported: Increased appetite

Olmesartan:

• Common (1% to 10%): Hypertriglyceridemia, hyperuricemia, hyperglycemia
• Rare (less than 0.1%): Hyperkalemia^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Cough, dyspnea

Amlodipine:

• Uncommon (0.1% to 1%): Dyspnea, rhinitis, epistaxis
• Very rare (less than 0.01%): Cough

Olmesartan:

• Common (1% to 10%): Bronchitis, cough, pharyngitis, rhinitis, sinusitis^[Ref]

Renal

• Uncommon (0.1% to 1%): Blood creatinine increased, blood uric acid increased

Olmesartan:

• Common (1% to 10%): Blood urea increased
• Rare (less than 0.1%): Acute renal failure, renal insufficiency, blood creatinine increased^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash
• Rare (less than 0.1%): Urticaria

Amlodipine:

• Uncommon (0.1% to 1%): Alopecia, exanthema, hyperhidrosis, pruritus, purpura, rash, skin discoloration, sweating increased, angioedema, rash erythematous, rash maculopapular
• Very rare (less than 0.01%): Angioneurotic edema, erythema multiforme, exfoliative dermatitis, photosensitivity, Quincke edema, Stevens-Johnson syndrome, urticaria
• Frequency not reported: Skin dryness, dermatitis, cold and clammy skin

Olmesartan:

• Uncommon (0.1% to 1%): Allergic dermatitis, exanthema, pruritus, rash, urticaria
• Rare (less than 0.1%): Angioneurotic edema
• Postmarketing reports: Angioedema, alopecia^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Libido decreased

Amlodipine:

• Uncommon (0.1% to 1%): Depression, insomnia, irritability, mood changes, sleep disorder, nervousness, abnormal dreams, anxiety, depersonalization
• Rare (less than 0.1%): Confusion
• Frequency not reported: Apathy, agitation^[Ref]

Hepatic

• Uncommon (0.1% to 1%): GGT increased

Amlodipine:

• Very rare (less than 0.01%): Hepatic enzymes increased, hepatitis, jaundice

Olmesartan:

• Common (1% to 10%): Hepatic enzymes increased^[Ref]

Immunologic

• Rare (less than 0.1%): Allergic reaction/drug hypersensitivity

Amlodipine:

• Uncommon (0.1% to 1%): Allergic reactions
• Very rare (less than 0.01%): Allergic reaction/drug hypersensitivity

Olmesartan:

• Uncommon (0.1% to 1%): Anaphylactic reaction^[Ref]

Ocular

Amlodipine:

• Uncommon (0.1% to 1%): Visual disturbance, abnormal vision, conjunctivitis, diplopia, eye pain
• Frequency not reported: Xerophthalmia^[Ref]

Hematologic

• Frequency not reported: Hemoglobin decreased, hematocrit decreased

Amlodipine:

• Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia

Olmesartan:

• Uncommon (0.1% to 1%): Thrombocytopenia^[Ref]

Further information

Azor side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer