Aspirin / Dipyridamole Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 30, 2024.

Applies to aspirin / dipyridamole: oral capsule extended release.

Serious side effects

Along with its needed effects, aspirin/dipyridamole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking aspirin / dipyridamole:

More common side effects

• abdominal or stomach pain
• vomiting

Less common side effects

• bleeding from the rectum
• bloody mucous or unexplained nosebleeds
• bloody or black, tarry stools
• confusion
• convulsions (seizures)
• difficulty with breathing
• difficulty with speaking
• double vision
• inability to move the arms, legs, or facial muscles
• inability to speak
• memory loss
• pale skin
• purple or red spots on skin
• slow speech
• tightness in the chest
• troubled breathing (exertional)
• unusual bleeding or bruising
• vomiting of blood or material that looks like coffee grounds

Rare side effects

• abdominal or stomach fullness
• blood in the urine
• chills
• clay-colored stools
• collection of blood under the skin
• cough
• deep, dark purple bruise
• gaseous abdominal or stomach pain
• itching, pain, redness, or swelling of the eye or eyelid
• loss of appetite
• nausea
• noisy breathing
• recurrent fever
• skin rash or hives (severe)
• watering of the eyes
• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking aspirin / dipyridamole:

Symptoms of overdose

• blurred vision
• continuing ringing or buzzing or other unexplained noise in the ears
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fast or irregular heartbeat
• flushes
• hearing loss
• restlessness
• sweating
• unusual tiredness or weakness
• warm feeling

Other side effects

Some side effects of aspirin / dipyridamole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• acid or sour stomach
• belching
• diarrhea
• difficulty with moving
• headache
• heartburn
• indigestion
• muscle pain or stiffness
• pain, swelling, or redness in the joints
• stomach discomfort or upset

Less common or rare side effects

• back pain
• burning feeling in the chest or stomach
• loss of strength or energy
• rectal pain or swelling
• sleepiness or unusual drowsiness
• taste loss
• tenderness in the stomach area

For healthcare professionals

Applies to aspirin / dipyridamole: oral capsule extended release.

General adverse events

The most common adverse reactions were headache, dizziness, dyspepsia, abdominal pain, nausea, and diarrhea.^[Ref]

Nervous system

• Very common (10% or more): Dizziness (up to 29.5%), headache (28.25%/year)
• Common (1% to 10%): Convulsions, syncope, amnesia, somnolence, intracranial hemorrhage
• Frequency not reported: Coma, paresthesia, cerebral hemorrhage, subarachnoid hemorrhage, tinnitus, taste loss
• Postmarketing reports: Cerebral edema, migraine

Aspirin:

• Very common (10% or more): Dizziness (29.2%), headache (22.1%/year)
• Common (1% to 10%): Convulsions, syncope, amnesia, somnolence
• Frequency not reported: Brain edema, lethargy, tinnitus

Dipyridamole:

• Very common (10% or more): Dizziness (30.1%), headache (27.91%/year)
• Common (1% to 10%): Convulsions, syncope, amnesia, somnolence^[Ref]

Gastrointestinal

• Very common (10% or more): Dyspepsia (13.23%/year), abdominal pain (12.62%/year), nausea (11.53%/year)
• Common (1% to 10%): Diarrhea, vomiting, rectum hemorrhage, melena, hemorrhoids, gastrointestinal hemorrhage
• Frequency not reported: Gastritis, ulceration, perforation, gingival bleeding
• Postmarketing reports: Pancreatitis, hematemesis, Reye syndrome, gastritis, ulceration and perforation, melena, GI hemorrhage

Aspirin:

• Very common (10% or more): Dyspepsia (11.84%/year), abdominal pain (10.38%/year)
• Common (1% to 10%): Nausea, diarrhea, vomiting, rectum hemorrhage, melena, hemorrhoids, gastrointestinal hemorrhage
• Frequency not reported: Gingival bleeding, gastric ulcer perforation, duodenal ulcer perforation, melena, hematemesis, pancreatitis

Dipyridamole:

• Very common (10% or more): Dyspepsia (12.68%/year), diarrhea (11.31%/year), abdominal pain (11.22%/year), nausea (11.18%/year)
• Common (1% to 10%): Vomiting, rectum hemorrhage, melena, hemorrhoids, gastrointestinal hemorrhage^[Ref]

Other

• Common (1% to 10%): Pain, fatigue, accidental injury, malaise, asthenia
• Frequency not reported: Fever, deafness
• Postmarketing reports: Hypothermia, chest pain, syncope, hearing loss, prolonged pregnancy and labor, stillbirths, lower birth weight infants, antepartum bleeding, postpartum bleeding

Aspirin:

• Common (1% to 10%): Pain, fatigue, accidental injury, malaise, asthenia
• Frequency not reported: Deafness, prolonged pregnancy, prolonged labor, stillbirth, lower birth weight infants, antepartum hemorrhage, postpartum hemorrhage, pyrexia, hypothermia

Dipyridamole:

• Common (1% to 10%): Pain, fatigue, accidental injury, malaise, asthenia^[Ref]

Respiratory

• Common (1% to 10%): Coughing, upper respiratory tract infection, epistaxis
• Frequency not reported: Hyperpnea, asthma, bronchospasm, hemoptysis, pulmonary edema
• Postmarketing reports: Respiratory alkalosis, laryngeal edema, tachypnea, dyspnea

Aspirin:

• Common (1% to 10%): Coughing, upper respiratory tract infection, epistaxis
• Frequency not reported: Dyspnea, laryngeal edema, hyperventilation, pulmonary edema, tachypnea

Dipyridamole:

• Common (1% to 10%): Coughing, upper respiratory tract infection, epistaxis^[Ref]

Hematologic

• Common (1% to 10%): Hemorrhage not otherwise specified, anemia, major bleeding
• Frequency not reported: Hematoma, hemoglobin decreased, hematocrit decreased, erythrocyte count decreased
• Postmarketing reports: Prolongation of prothrombin time, disseminated intravascular coagulation, coagulopathy, thrombocytopenia, aplastic anemia, pancytopenia, thrombocytosis, hematoma, gingival bleeding, epistaxis, purpura

Aspirin:

• Common (1% to 10%): Hemorrhage not otherwise specified, anemia
• Frequency not reported: Disseminated intravascular coagulation, coagulopathy

Dipyridamole:

• Common (1% to 10%): Hemorrhage not otherwise specified, anemia^[Ref]

Cardiovascular

• Common (1% to 10%): Cardiac failure
• Frequency not reported: Hypotension, tachycardia, palpitation, arrhythmia, supraventricular tachycardia, flushing
• Postmarketing reports: Angina pectoris, hypotension

Aspirin:

• Common (1% to 10%): Cardiac failure
• Frequency not reported: Arrhythmia

Dipyridamole:

• Common (1% to 10%): Cardiac failure^[Ref]

Dermatologic

• Common (1% to 10%): Purpura
• Frequency not reported: Pruritus, urticaria
• Postmarketing reports: Rash, alopecia, angioedema, Stevens-Johnson syndrome, skin hemorrhages, bruising, ecchymosis, hematoma, pruritus, urticaria, and drug reaction with eosinophilia and systemic symptoms (DRESS)

Aspirin:

• Common (1% to 10%): Purpura
• Frequency not reported: Erythema exudativum multiforme

Dipyridamole:

• Common (1% to 10%): Purpura^[Ref]

Metabolic

• Common (1% to 10%): Anorexia
• Frequency not reported: Hyperglycemia, thirst
• Postmarketing reports: Hyperkalemia, metabolic acidosis, hypokalemia, hypoglycemia, dehydration

Aspirin:

• Common (1% to 10%): Anorexia
• Frequency not reported: Hyperglycemia, thirst, dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis

Dipyridamole:

• Common (1% to 10%): Anorexia^[Ref]

Psychiatric

• Common (1% to 10%): Confusion
• Frequency not reported: Agitation

Aspirin:

• Common (1% to 10%): Confusion
• Frequency not reported: Agitation

Dipyridamole:

• Common (1% to 10%): Confusion^[Ref]

Postmarketing: Confusion and agitation

Musculoskeletal

• Common (1% to 10%): Back pain
• Postmarketing reports: Rhabdomyolysis, myalgia

Aspirin:

• Common (1% to 10%): Back pain
• Frequency not reported: Rhabdomyolysis

Dipyridamole:

• Common (1% to 10%): Back pain^[Ref]

Oncologic

• Common (1% to 10%): Neoplasm not otherwise specified

Aspirin:

• Common (1% to 10%): Neoplasm not otherwise specified

Dipyridamole:

• Common (1% to 10%): Neoplasm not otherwise specified^[Ref]

Hepatic

• Frequency not reported: Cholelithiasis, jaundice, hepatic function abnormal
• Postmarketing reports: Reye's syndrome, hepatitis, hepatic failure, jaundice

Aspirin:

• Frequency not reported: Hepatitis, Reye's syndrome^[Ref]

Renal

• Frequency not reported: Renal insufficiency, renal failure
• Postmarketing reports: Interstitial nephritis, papillary necrosis, proteinuria, hematuria

Aspirin:

• Frequency not reported: Renal failure, interstitial nephritis, papillary necrosis^[Ref]

Genitourinary

• Frequency not reported: Uterine hemorrhage, hematuria
• Postmarketing reports: Proteinuria

Aspirin:

• Frequency not reported: Proteinuria^[Ref]

Immunologic

• Frequency not reported: Allergic reaction
• Postmarketing reports: Hypersensitivity, acute anaphylaxis

Aspirin:

• Frequency not reported: Anaphylactic reactions^[Ref]

Further information

Aspirin/dipyridamole side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer