Apalutamide Side Effects
Medically reviewed by Drugs.com. Last updated on Sep 28, 2022.
Applies to apalutamide: oral tablets.
Side effects include:
Fatigue/asthenia, hypertension, rash, diarrhea, nausea, weight loss, arthralgia, falls, hot flush, decreased appetite, fracture, peripheral edema, hypercholesterolemia, hyperglycemia, anemia, hypertriglyceridemia, leukopenia, lymphopenia, hyperkalemia.
For Healthcare Professionals
Applies to apalutamide: oral tablet.
The most frequently reported side effects are fatigue, hypertension, rash, diarrhea, nausea, weight decreased, arthralgia, fall, hot flush, appetite decreased, fracture, and peripheral edema.[Ref]
Very common (10% or more): Anemia (70%), leukopenia (47%), lymphopenia (41%)[Ref]
Very common (10% or more): Hypercholesterolemia (76%), hyperglycemia (70%), hypertriglyceridemia (67%), hyperkalemia (32%), appetite disorder (appetite decreased, early satiety, hypophagia) (12%)[Ref]
Very common (10% or more): Fatigue/asthenia (39%), fall (16%), edema (peripheral edema, generalized edema, edema, edema genital, penile edema, peripheral swelling, scrotal edema, lymphedema, swelling, localized edema) (11%)[Ref]
Very common (10% or more): Hypertension (25%), hot flush (14%)
Common (1% to 10%): Ischemic heart disease, heart failure
Frequency not reported: Myocardial infarction, cardiopulmonary arrest[Ref]
Very common (10% or more): Rash (maculopapular rash, generalized rash, urticaria, rash pruritic, rash macular, conjunctivitis, erythema multiforme, rash papular, skin exfoliation, genital rash, rash erythematous, stomatitis, drug eruption, mouth ulceration, rash pustular, blister, papule, pemphigoid, skin erosion, and rash vesicular) (24%)
Very common (10% or more): Thyroid stimulating hormone elevated
Common (1% to 10%): Hypothyroidism[Ref]
Very common (10% or more): Diarrhea (20%), nausea (18%)[Ref]
Uncommon (0.1% to 1%): Seizure
Very common (10% or more): Arthralgia (16%), fracture (e.g., rib fracture, lumbar vertebral fracture, spinal compression fracture, spinal fracture, foot fracture, hip fracture, humerus fracture, thoracic vertebral fracture, upper limb fracture, fractured sacrum, hand fracture, pubis fracture, acetabulum fracture, ankle fracture, compression fracture, costal cartilage fracture, facial bones fracture, lower limb fracture, osteoporotic fracture, wrist fracture, avulsion fracture, fibula fracture, fractured coccyx, pelvic fracture, radius fracture, sternal fracture, stress fracture, traumatic fracture, cervical vertebral fracture, femoral neck fracture, tibia fracture) (12%)[Ref]
Frequency not reported: Infection[Ref]
Frequently asked questions
- Erleada vs. Xtandi: What's the difference?
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More about apalutamide
- Check interactions
- Reviews (3)
- Dosage information
- During pregnancy
- Drug class: antiandrogens
- En español
Related treatment guides
1. "Product Information. Erleada (apalutamide)." Janssen Biotech, Inc. (2018):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.